The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Neuroimmune Axes of the Blood–Brain Barriers and Blood–Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions
Open accessAbstract
Central nervous system (CNS) barriers predominantly mediate the immune-privileged status of the brain, and are also important regulators of neuroimmune communication.It is increasingly appreciated that communication between the brain and immune system contributes to physiologic processes, adaptive responses, and disease states.In this review, we discuss the highly specialized features of brain barriers that regulate neuroimmune communication in health and disease.In section I, we discuss the concept of immune privilege, provide working definitions of brain barriers, and outline the historical work that contributed to the understanding of CNS barrier functions.In section II, we discuss the unique anatomic, cellular, and molecular characteristics of the vascular blood-brain barrier (BBB), blood-cerebrospinal fluid barrier, and tanycytic barriers that confer their functions as neuroimmune interfaces.In section III, we consider BBB-mediated neuroimmune functions and interactions categorized as five neuroimmune axes: disruption, responses to immune stimuli, uptake and transport of immunoactive substances, immune cell trafficking, and secretions of immunoactive substances.In section IV, we discuss neuroimmune functions of CNS barriers in physiologic and disease states, as well as pharmacological interventions for CNS diseases.Throughout this review, we highlight many recent advances that have contributed to the modern understanding of CNS barriers and their interface functions.
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“The BBB is comprised of brain endothelial cells that prevent the unregulated leakage of substances from the blood into the brain, and it further acts as an interface that regulates the exchange of substances between the brain and circulation [16,17].”
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The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice
Rhea, E. M., Logsdon, A. F., Hansen, K. M., Williams, L. M., Reed, M. J., Baumann, K. K., Holden, S. J., Raber, J., Banks, W. A., & Erickson, M. A. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00771-8 · Cited by 419
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Metadata
- Authors
- Erickson, M. A., & Banks, W. A.
- Venue
- Pharmacological Reviews
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 70
- Issue
- 2
- Pages
- 278-314
- ISSN
- 0031-6997 (ISSN-L)
- OpenAlex
- W2790827715
- Cited by
- 378
- References
- 84
- FWCI
- 14.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
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