The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Hyaluronic acid: A review on its biology, aspects of drug delivery, route of administrations and a special emphasis on its approved marketed products and recent clinical studies
Abstract
Hyaluronic acid (HA) is a large non-sulphated glycosaminoglycan that is an important component of extracellular matrix (ECM) and a biodegradable polymer. Due to a variation in its molecular weight, HA derivatives can be utilized to make different formulations like fillers, creams, gels and drops. HA based drug research has seen a recent surge largely due to some properties like mucoadhesion, biocompatibility and ease of chemical modification. Such properties of HA have led to applications in tissue regeneration, anti-aging and anti-inflammatory medications. HA can be conjugated, functionalized or used as a nanocarrier supplement with a definite increase in its cellular uptake and efficiency. HA when encapsulated in a nanocarrier may help to improve the ECM growth and provide a sustained release of agents. This review discusses the mechanistic behavior of HA pertaining to its biological synthesis and degradation. It also discusses the administration of some noteworthy and recent HA based formulations through different routes for application in various physiological conditions along with their ongoing clinical trial updates and approved marketed products.
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Cites
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Hyaluronic acid in ocular drug delivery
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Hyaluronic Acid as a Component of Natural Polymer Blends for Biomedical Applications: A Review
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3D printing to innovate biopolymer materials for demanding applications: A review
Li, N., Qiao, D., Zhao, S., Lin, Q., Zhang, B., & Xie, F. (2021) · Materials Today Chemistry · doi:10.1016/j.mtchem.2021.100459 · Cited by 142
Targeting tumor extracellular matrix with nanoparticles to circumvent therapeutic resistance
Ding, X., Liang, Y., Zhou, S., Wu, Y., Sałata, P., Mikolajczk-Martinez, A., Khosrawipour, V., & Zhang, Z. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113786 · Cited by 20
Metadata
- Authors
- Vasvani, S., Kulkarni, P., & Rawtani, D.
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 151
- Pages
- 1012-1029
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W2984872557
- Cited by
- 473
- References
- 9
- FWCI
- 15.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vasvani, S., Kulkarni, P., & Rawtani, D. (2020). Hyaluronic acid: A review on its biology, aspects of drug delivery, route of administrations and a special emphasis on its approved marketed products and recent clinical studies. International Journal of Biological Macromolecules. https://doi.org/10.1016/j.ijbiomac.2019.11.066
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
