The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice
Open accessAbstract
It is unclear whether severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019, can enter the brain. Severe acute respiratory syndrome coronavirus 2 binds to cells via the S1 subunit of its spike protein. We show that intravenously injected radioiodinated S1 (I-S1) readily crossed the blood–brain barrier in male mice, was taken up by brain regions and entered the parenchymal brain space. I-S1 was also taken up by the lung, spleen, kidney and liver. Intranasally administered I-S1 also entered the brain, although at levels roughly ten times lower than after intravenous administration. APOE genotype and sex did not affect whole-brain I-S1 uptake but had variable effects on uptake by the olfactory bulb, liver, spleen and kidney. I-S1 uptake in the hippocampus and olfactory bulb was reduced by lipopolysaccharide-induced inflammation. Mechanistic studies indicated that I-S1 crosses the blood–brain barrier by adsorptive transcytosis and that murine angiotensin-converting enzyme 2 is involved in brain and lung uptake, but not in kidney, liver or spleen uptake. Rhea at al. show that intravenously injected, radiolabeled SARS-CoV-2 spike 1 protein crosses the mouse blood–brain barrier, likely through the mechanism of adsorptive transcytosis and is also taken up by peripheral tissues.
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Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China
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Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
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Structural basis of receptor recognition by SARS-CoV-2
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How COVID-19 shaped mental health: from infection to pandemic effects
Penninx, B. W. J. H., Benros, M. E., Klein, R. S., & Vinkers, C. H. (2022) · Nature Medicine · doi:10.1038/s41591-022-02028-2 · Cited by 445
Silva Andrade, B., Siqueira, S., de Assis Soares, W. R., de Souza Rangel, F., Santos, N. O., dos Santos Freitas, A., Ribeiro da Silveira, P., Tiwari, S., Alzahrani, K. J., Góes-Neto, A., et al. (2021) · Viruses · doi:10.3390/v13040700 · Cited by 435
Greene, C., Connolly, R., Brennan, D., Laffan, A., O’Keeffe, E., Zaporojan, L., O’Callaghan, J., Thomson, B., Connolly, E., Argue, R., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01576-9 · Cited by 429
Understanding COVID-19-associated coagulopathy
Conway, E. M., Mackman, N., Warren, R. Q., Wolberg, A. S., Mosnier, L. O., Campbell, R. A., Gralinski, L. E., Rondina, M. T., van de Veerdonk, F. L., Hoffmeister, K. M., et al. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-022-00762-9 · Cited by 359
Metadata
- Authors
- Rhea, E. M., Logsdon, A. F., Hansen, K. M., Williams, L. M., Reed, M. J., Baumann, K. K., Holden, S. J., Raber, J., Banks, W. A., & Erickson, M. A.
- Venue
- Nature Neuroscience
- Published
- 2020-12-16
- Volume
- 24
- Issue
- 3
- Pages
- 368-378
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W3110926944
- Cited by
- 419
- References
- 62
- FWCI
- 24.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rhea, E. M., Logsdon, A. F., Hansen, K. M., Williams, L. M., Reed, M. J., Baumann, K. K., Holden, S. J., Raber, J., Banks, W. A., & Erickson, M. A. (2021). The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice. Nature Neuroscience. https://doi.org/10.1038/s41593-020-00771-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
