Pharmacological Agents That Directly Modulate Insulin Secretion

Role of microtubules in the synthesis, conversion, and release of (pro)insulin. A biochemical and radioautographic study in rat islets.

MALAISSE-LAGAE, F., Amherdt, M., Ravazzola, M., Sener, A., Hutton, J. C., Orci, L., & Malaisse, W. J. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109423 · Cited by 56

Defects in carbohydrate metabolism in oral contraceptive users without apparent metabolic risk factors

Watanabe, R. M., Azen, C., Roy, S., Perlman, J. A., & Bergman, R. N. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.5.7962320 · Cited by 55

Suppression of the Expression of a Pancreatic -Cell Form of the Kinesin Heavy Chain by Antisense Oligonucleotides Inhibits Insulin Secretion from Primary Cultures of Mouse -Cells

Meng, Y. X., Wilson, G., Avery, M. C., Varden, C. E., & Balczon, R. (1997) · Endocrinology · doi:10.1210/endo.138.5.5139 · Cited by 55

Glucose Tolerance, Glucose Utilization and Insulin Secretion in Ageing

Elahi, D., Muller, D. C., Egan, J. M., Andres, R., Veldhuis, P. P., & Meneilly, G. S. (2002) · Novartis Foundation symposium · doi:10.1002/0470846542.ch14 · Cited by 54

Sulfonylurea-Mediated Stimulation of Insulin Exocytosis via an ATP-Sensitive K+ Channel–Independent Action

Renström, E., Barg, S., Thévenod, F., & Rorsman, P. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s33 · Cited by 54

Comparative aspects of the function and mechanism of SUR1 and MDR1 proteins.

Ueda, K., Matsuo, M., Tanabe, K., Morita, K., Kioka, N., & Amachi, T. (1999) · Biochimica et Biophysica Acta · doi:10.1016/s0005-2736(99)00157-1 · Cited by 54

Reduced Pancreatic B Cell Compensation to the Insulin Resistance of Aging: Impact on Proinsulin and Insulin Levels

Røder, M. E., Schwartz, R. S., Prigeon, R. L., & Kahn, S. E. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.6.6635 · Cited by 54

Age at menarche.

Baxter-Jones, A., Helms, P., & Preece, M. (1994) · PubMed · Cited by 53

Somatostatin activates two types of inwardly rectifying K+ channels in MIN‐6 cells

Smith, P. A., Sellers, L. A., & Humphrey, P. P. A. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.0127g.x · Cited by 53

Characterization of the G protein coupling of a somatostatin receptor to the K+ATP channel in insulin‐secreting mammalian HIT and RIN cell lines.

Ribalet, B., & Eddlestone, G. T. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020713 · Cited by 53

Single Ca channel currents in mouse pancreatic B-cells

Rorsman, P., Ashcroft, F. M., & Trube, G. (1988) · Pflügers Archiv · doi:10.1007/bf00583760 · Cited by 52

Age-dependent reduction in insulin secretion and insulin mRNA in isolated islets from rats

Perfetti, R., Rafizadeh, C. M., Liotta, A. S., & Egan, J. M. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.269.6.e983 · Cited by 52

Two types of Ca channel in rat pancreatic ?-cells

Ashcroft, F. M., Kelly, R. P., & Smith, P. A. (1990) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00373633 · Cited by 51

Effects of protein kinase C inhibitors on insulin secretory responses from rodent pancreatic islets

Zawalich, W. S., & Zawalich, K. C. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00422-1 · Cited by 51

Diabetogenic Effect of Cyclosporin A Is Mediated by Interference with Mitochondrial Function of Pancreatic B-Cells

Düfer, M., Krippeit‐Drews, P., Lembert, N., Idahl, L., & Drews, G. (2001) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12316-4 · Cited by 51

Effect of Troglitazone on B Cell Function, Insulin Sensitivity, and Glycemic Control in Subjects with Type 2 Diabetes Mellitus

Prigeon, R. L. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.3.819 · Cited by 51

Carbohydrate Metabolism In Male Infertility And Female Fertility-Control Patients

Wallach, E. E., & Spellacy, W. N. (1976) · Fertility and Sterility · doi:10.1016/s0015-0282(16)42129-1 · Cited by 50

Protein Kinases, Protein Phosphorylation, and the Regulation of Insulin Secretion from Pancreatic -Cells.

Jones, P. M. (1998) · Endocrine Reviews · doi:10.1210/er.19.4.429 · Cited by 50

The underreporting of results and possible mechanisms of ‘negative’ drug trials in patients with chronic heart failure

van Veldhuisen, D. J., & Poole-Wilson, P. A. (2001) · International Journal of Cardiology · doi:10.1016/s0167-5273(01)00447-8 · Cited by 49

Glucagon: hormone or therapeutic agent?

Hall-Boyer, K., Zaloga, G. P., & Chernow, B. (1984) · PubMed · Cited by 49

Effects of type‐selective phosphodiesterase inhibitors on glucose‐induced insulin secretion and islet phosphodiesterase activity

Shafiee-Nick, R., Pyne, N. J., & Furman, B. L. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb16641.x · Cited by 48

Incretin hormones regulate glucose-dependent insulin secretion in RIN 1046-38 cells: mechanisms of action

Montrose‐Rafizadeh, C., Egan, J., & Roth, J. (1994) · Endocrinology · doi:10.1210/endo.135.2.8033807 · Cited by 45

The interplay between cyclic AMP and ions in the stimulus-secretion coupling in pancreatic B-cells

Henquin, J. C. (1985) · Archives Internationales de Physiologie et de Biochimie · doi:10.3109/13813458509104514 · Cited by 45

N-terminally modified glucagon-like peptide-1(7–36) amide exhibits resistance to enzymatic degradation while maintaining its antihyperglycaemic activity in vivo

O'Harte, F. P. M., Mooney, M. H., Lawlor, A., & Flatt, P. R. (2000) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(99)00214-7 · Cited by 44

Structural Basis for the Interference Between Nicorandil and Sulfonylurea Action

Reimann, F. M., Ashcroft, F. M., & Gribble, F. M. (2001) · Diabetes · doi:10.2337/diabetes.50.10.2253 · Cited by 43

THE EFFECT OF (STEROID) IMMUNOSUPPRESSION ON SKELETAL MUSCLE GLYCOGEN METABOLISM IN PATIENTS AFTER KIDNEY TRANSPLANTATION

Ekstrand, A., Schalin‐Jäntti, C., fman, M. L., Parkkonen, M., Wid�n, E., Franssila-Kallunki, A., Saloranta, C., Koivisto, V. A., & Groop, L. (1996) · Transplantation · doi:10.1097/00007890-199603270-00008 · Cited by 42

Glucagon-Like Peptide 1 Increases Mass But Not Frequency or Orderliness of Pulsatile Insulin Secretion

Pørksen, N. K., Grøfte, T., Nyholm, B., Holst, J. J., Pincus, S. M., Veldhuis, J. D., Schmitz, O., & Butler, P. C. (1998) · Diabetes · doi:10.2337/diab.47.1.45 · Cited by 41

Prospective Studies of Carbohydrate Metabolism in “Normal” Women Using Norgestrel for Eighteen Months

Spellacy, W. N., Buhi, W. C., & Birk, S. A. (1981) · Fertility and Sterility · doi:10.1016/s0015-0282(16)45317-3 · Cited by 41

Quinine-Induced Hypoglycemia

Limburg, P. J., Katz, H., Grant, C. S., & Service, F. J. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-119-3-199308010-00007 · Cited by 40

Post–renal transplant diabetes mellitus—a retrospective study

Rao, M., Jacob, C. K., & Shastry, J. C. M. (1992) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/7.10.1039 · Cited by 40

Transcriptional and Translational Control of Glucose‐Stimulated (Pro)insulin Biosynthesis

Jahr, H., SCHRODER, D. K., Ziegler, B., ZIEGLER, M., & Zühlke, H. (1980) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1980.tb04892.x · Cited by 39

Reduced Pancreatic B Cell Compensation to the Insulin Resistance of Aging: Impact on Proinsulin and Insulin Levels

Røder, M. E. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.6.2275 · Cited by 39

A Dose-Dependent Increase in Mortality with Vesnarinone Among Patients with Severe Heart Failure

Cohn, J. N., Goldstein, S., Greenberg, B., Lorell, B. H., Bourge, R. C., Jaski, B. E., Gottlieb, S. O., McGrew, F. A., DeMets, D. L., & White, B. G. (1999) · Survey of Anesthesiology · doi:10.1097/00132586-199910000-00011 · Cited by 37

Effects of Glucose, Exogenous Insulin, and Carbachol on C-peptide and Insulin Secretion from Isolated Perifused Rat Islets

Zawalich, W. S., & Zawalich, K. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202291200 · Cited by 36

Lack of effect of long-term amlodipine on insulin sensitivity and plasma insulin in obese patients with essential hypertension

de Courten, M., Ferrari, P., Schneider, M. A., Böhlen, L., Shaw, S., Riesen, W., Heynen, G., & Weidmann, P. U. (1993) · European Journal of Clinical Pharmacology · doi:10.1007/bf00315543 · Cited by 35

Membrane and intracellular effects of adenosine in mouse pancreatic beta-cells

Bertrand, G., Petit, P., Bozem, M., & Henquin, J. C. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.257.4.e473 · Cited by 35

Cholinergic enhancement by pyridostigmine increases the insulin response to glucose load in obese patients but not in normal subjects

Rió, G. D., Massimo, P., Bondi, M., Marrama, P., Menozzi, R., Oleandri, S. E., Grottoli, S., Maccario, M., Velardo, A., & Ghigo, E. (1997) · International Journal of Obesity · doi:10.1038/sj.ijo.0800523 · Cited by 33

The cytoskeleton and insulin secretion

Howell, S. L., & Tyhurst, M. (1986) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610020107 · Cited by 32

Ligand-specificity of the rat GLP-I receptor recombinantly expressed in Chinese hamster ovary (CHO-) cells.

Fehmann, H. C., Jiang, J., Schweinfurth, J., Dorsch, K., Wheeler, M. B., Boyd, A. E., & Göke, B. (1994) · PubMed · Cited by 32

Insertion of an N-Terminal 6-Aminohexanoic Acid after the 7 Amino Acid Position of Glucagon-Like Peptide-1 Produces a Long-Acting Hypoglycemic Agent

Doyle, M. E., Greig, N. H., Holloway, H. W., Betkey, J. A., Bernier, M., & Egan, J. M. (2001) · Endocrinology · doi:10.1210/endo.142.10.8410 · Cited by 31

Hypoglycaemia and Diabetes Mellitus Following Parenteral Pentamidine Mesylate Treatment in AIDS Patients

Perronne, C., Bricaire, F., Leport, C., Assan, D., Vildé, J., & Assan, R. (1990) · Diabetic Medicine · doi:10.1111/j.1464-5491.1990.tb01453.x · Cited by 30

The identification, purification, and characterization of a pancreatic beta-cell form of the microtubule adenosine triphosphatase kinesin

Balczon, R., Overstreet, K. A., Zinkowski, R. P., Haynes, A., & Appel, M. (1992) · Endocrinology · doi:10.1210/endo.131.1.1612013 · Cited by 29

Functional and morphological modifications induced in rat islets by pentamidine and other diamidines in vitro

Boillot, D., Veld, P. I. '., Saï, P., Feutren, G., Gepts, W., & Assan, R. (1985) · Diabetologia · doi:10.1007/bf00283144 · Cited by 28

Low dose clonidine premedication accentuates the hyperglycemic response to surgery

Lattermann, R., Schricker, T., Georgieff, M., & Schreiber, M. N. (2001) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03016690 · Cited by 27

Impact of immunosuppressive regimes on posttransplant diabetes mellitus

Weir, M. (2001) · Transplantation Proceedings · doi:10.1016/s0041-1345(01)02231-x · Cited by 26

Adrenaline-, not somatostatin-induced hyperpolarization is accompanied by a sustained inhibition of insulin secretion in INS-1 cells. Activation of sulphonylurea KATP+ channels is not involved

Abel, K.-B., Lehr, S., & Ullrich, S. (1996) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050109 · Cited by 25

Higher Pentamidine Levels in AIDS Patients with Hypoglycemia and Azotemia during Treatment of Pneumocystis carinii Pneumonia

Comtois, R., Pouliot, J., Vinet, B., Gervais, A., & Lemieux, C. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/146.3.740 · Cited by 25

Influence of verapamil on human glucose tolerance

Röjdmark, S., & Andersson, D. (1986) · The American Journal of Cardiology · doi:10.1016/0002-9149(86)90804-0 · Cited by 24

Insulin Release and the Microtubular System of the Islets of Langerhans: Effects of Insulin Secretagogues on Microtubule Subunit Pool Size

MONTAGUE, W., Howell, S. L., & Green, I. (1976) · Hormone and Metabolic Research · doi:10.1055/s-0028-1093653 · Cited by 24

Glucagon-Like Peptide-1 Causes Pancreatic Duodenal Homeobox-1 Protein Translocation from the Cytoplasm to the Nucleus of Pancreatic -Cells by a Cyclic Adenosine Monophosphate/Protein Kinase A-Dependent Mechanism

Wang, X. (2001) · Endocrinology · doi:10.1210/en.142.5.1820 · Cited by 24

Muscle Uridine Diphosphate-Hexosamines Do Not Decrease Despite Correction of Hyperglycemia-Induced Insulin Resistance in Type 2 Diabetes

Pouwels, M.-J. J., Span, P. N., Tack, C. J., Olthaar, A. J., Sweep, F. C. G. J., van Engelen, B. G. M., de Jong, J. G. N., Lutterman, J. A., & Hermus, A. R. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020440 · Cited by 22

Glucose-induced insulin secretion is potentiated by a new imidazoline compound

Mest, H.-J. X. F. R., Raap, A., Schloos, J., Treinies, I., Paal, M., Giese, U., & Koivisto, V. A. (2001) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002100100415 · Cited by 21

Distributional Patterns of Phospholipase C Isozymes in Rat Pancreas

Kim, M.-J., Lee, K.-H., Min, D. S., Yoon, S.-H., Hahn, S. J., Kim, M.-S., & Jo, Y. (2001) · Pancreas · doi:10.1097/00006676-200101000-00008 · Cited by 21

Effect of rate of infusion of quinine on insulin and glucose responses in Malawian children with falciparum malaria.

Molyneux, M. E., Taylor, T. E., Wirima, J. J., & Harper, G. (1989) · BMJ · doi:10.1136/bmj.299.6699.602 · Cited by 21

Effects of acute α2-blockade on insulin action and secretion in humans

Natali, A., Gastaldelli, A., Galvan, A. Q., Sironi, A. M., Ciociaro, D., Sanna, G., Rosenzweig, P., & Ferrannini, E. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.1.e57 · Cited by 21

Effects of Antihypertensive Drugs on Endocrine Function

Brass, E. P. (1984) · Drugs · doi:10.2165/00003495-198427050-00004 · Cited by 20

Glucagon-like Peptide-1 (7-37) Augments Insulin-Mediated Glucose Uptake in Elderly Patients With Diabetes

Meneilly, G. S., McIntosh, C. H. S., Pederson, R. A., Habener, J. F., Gingerich, R. L., Egan, J. M., & Elahi, D. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.11.m681 · Cited by 20

British regional heart study.

Walker, M. (1984) · PubMed · Cited by 20

Verapamil, a phenylalkylamine Ca 2 + channel blocker, inhibits ATP-sensitive K + channels in insulin-secreting cells from rats

Lebrun, P., Antoine, M.-H., Ouedraogo, R., Pirotte, B., Herchuelz, A., Cosgrove, K. E., Kane, C. A., & Dunne, M. J. (1997) · Diabetologia · doi:10.1007/s001250050842 · Cited by 19

Glucosamine-induced β-cell Dysfunction: A Possible Involvement of Glucokinase or Glucose-transporter Type 2

Yoshikawa, H., Tajiri, Y., Sako, Y., Hashimato, T., Umeda, F., & Nawata, H. (2002) · Pancreas · doi:10.1097/00006676-200204000-00004 · Cited by 18

Pancreatic beta-cell somatostatin receptors

Thermos, K., Meglasson, M. D., Nelson, J., et al. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.259.2.e216 · Cited by 17

Effect of pertussis toxin on islet insulin secretion in obese (fa/fa) Zucker rats

Cawthorn, E. G., & Chan, C. B. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90161-k · Cited by 17

SNAP-25 Is Phosphorylated by Glucose and GLP-1 in RIN 1046-38 Cells

Zhou, J., & Egan, J. M. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7286 · Cited by 16

Pancreatic pathology in pentamidine-induced diabetes in acquired immunodeficiency syndrome patients

Hauser, L., Sheehan, P., & Simpkins, H. (1991) · Human Pathology · doi:10.1016/0046-8177(91)90185-r · Cited by 16

Differential effects of short and long duration insulinotropic agents on meal‐related glucose excursions

de Souza, C. J., Russo, P. A., Lozito, R. J., & Dunning, B. E. (2001) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2001.00114.x · Cited by 16

Stimulatory Transducing Systems in Pancreatic Islet Cellsa

Emami, S., Régnauld, K., Ferrand, N., Astesano, A., Pessah, M., PHAN, H., Boissard, C., Garel, J., & Rosselin, G. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb11170.x · Cited by 15

Implications of the United Kingdom Prospective Diabetes Study (UKPDS) results on patient management.

Nicollerat, J. (2002) · PubMed · Cited by 14

24-h blood glucose pattern in type I and type II diabetics after oral treatment with pentoxifylline as assessed by artificial endocrine pancreas

Raptis, S. A., Mitrakou, A., Hadjidakis, D., Diamantopoulos, E. J., Anastasiou, C. A., Fountas, A., & Müller, R. (1987) · Acta Diabetologica · doi:10.1007/bf02732036 · Cited by 11

Smoking and Diabetes

American Diabetes Association (2002) · Diabetes Care · doi:10.2337/diacare.25.2007.s80 · Cited by 11

Subcellular Distribution of Phospholipase C Isoforms in Rodent Pancreas and Gastric Mucosa

Wang, S., Lukinius, A., Zhou, Y., Stalberg, P. L. H., Gobl, A., Öberg, K., & Skogseid, B. M. (2000) · Endocrinology · doi:10.1210/endo.141.7.7533 · Cited by 10

Clonidine and Glucose Intolerance

Webster, W. B., & McConnaughey, M. M. (1982) · Annals of Pharmacotherapy · doi:10.1177/106002808201600409 · Cited by 10

Age at menarche

Baxter-Jones, A. D. G., Helms, P. J. B., Preece, M. A., Stone, P., Dann, T. C., & Roberts, D. F. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91261-0 · Cited by 10

Reversal of pentamidine-induced hypoglycaemia with oral diazoxide.

Db, F., & Young, I. S. (1984) · PubMed · Cited by 7

Comparison of Effects of Nicardipine and Trichlormethiazide on Insulin Sensitivity in Hypertensive Patients

Kageyama, S., Yamamoto, J., Mimura, A., Ishibashi, K., Sakurai, T., Yokota, K., Isogai, Y., & Fujita, T. (1994) · American Journal of Hypertension · doi:10.1093/ajh/7.5.474 · Cited by 6

Non-radioisotopic glucose turnover in children with falciparum malaria and enteric fever

Singh, B. B., Choo, K. E., Ibrahim, J., Johnston, W. A., & Davis, T. M. E. (1998) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(98)90903-8 · Cited by 4

Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles

Hibino, H., Inanobe, A., Furutani, K., Murakami, S., Findlay, I., & Kurachi, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00021.2009 · Cited by 1,539

The role of incretins in glucose homeostasis and diabetes treatment

Kim, W., & Egan, J. M. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.000604 · Cited by 824

Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia

Miyakawa, T., Leiter, L. M., Gerber, D. J., Gainetdinov, R. R., Sotnikova, T. D., Zeng, H., Caron, M. G., & Tonegawa, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432926100 · Cited by 489

The role of α-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications

Dunning, B. E., & Gerich, J. E. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0026 · Cited by 369

Postprandial Glucose Regulation and Diabetic Complications

Ceriello, A. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.19.2090 · Cited by 362