Postprandial Glucose Regulation and Diabetic Complications

Ceriello, Antonio

doi:10.1001/archinte.164.19.2090

Cited by 362Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and ManagementDiabetes Management and Research

Postprandial Glucose Regulation and Diabetic Complications

Ceriello, Antonio·2004·Archives of Internal Medicine

DOI 10.1001/archinte.164.19.2090

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Abstract

Atherosclerotic disease accounts for much of the increased mortality and morbidity associated with type 2 diabetes. Epidemiological studies support the potential of improved glycemic control to reduce cardiovascular complications. An association between glycosylated hemoglobin (HbA(1c)) level and the risk for cardiovascular complications has frequently been reported. Most epidemiological data implicate postprandial hyperglycemia in the development of cardiovascular disease, whereas the link between fasting glycemia and diabetic complications is inconclusive. Moreover, in many studies, postprandial glycemia is a better predictor of cardiovascular risk than HbA(1c) level. Postprandial glucose may have a direct toxic effect on the vascular endothelium, mediated by oxidative stress that is independent of other cardiovascular risk factors such as hyperlipidemia. Postprandial hyperglycemia also may exert its effects through its substantial contribution to total glycemic exposure. The present review examines the hypothesis that controlling postprandial glucose level is an important strategy in the prevention of cardiovascular complications associated with diabetes.

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Postprandial hypertriglyceridemia and hyperglycemia are regarded as cardiovascular risk factors.
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From Effect of Atorvastatin and Irbesartan, Alone and in Combination, on Postprandial Endothelial Dysfunction, Oxidative Stress, and Inflammation in Type 2 Diabetic Patients (2005) · cites this paper as [3]

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Background
Postprandial hyperglycaemia and cardiovascular complications of diabetes: An update
Ceriello, A., Davidson, J., Markolf Hanefeld, E., Leiter, L. A., Monnier, L., Owens, D. R., Tajima, N., & Tuomilehto, J. O. (2006) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.05.006 · Cited by 149 · see citing works
Self-citation
Management of Type 1 Diabetes With a Very Low–Carbohydrate Diet
Lennerz, B. S., Barton, A. B., Bernstein, R. K., Dikeman, R. D., Diulus, C. A., Hallberg, S. J., Rhodes, E. T., Ebbeling, C. B., Westman, E. C., Yancy, W. S., et al. (2018) · PEDIATRICS · doi:10.1542/peds.2017-3349 · Cited by 149 · see citing works
Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control
Lang Lehrskov, L., Lyngbaek, M. P., Soederlund, L., Legaard, G. E., Ehses, J. A., Heywood, S. E., Wewer Albrechtsen, N. J., Holst, J. J., Karstoft, K., Pedersen, B. K., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.04.008 · Cited by 135 · see citing works
ROSES: role of self‐monitoring of blood glucose and intensive education in patients with Type 2 diabetes not receiving insulin. A pilot randomized clinical trial
Franciosi, M., Lucisano, G., Pellegrini, F., Cantarello, A., Consoli, A., Cucco, L., Ghidelli, R., Sartore, G., Sciangula, L., Nicolucci, A., et al. (2011) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03268.x · Cited by 137 · see citing works
Early Progression of Diabetic Nephropathy Correlates With Methylglyoxal-Derived Advanced Glycation End Products
Beisswenger, P. J., Howell, S. K., Russell, G. B., Miller, M. E., Rich, S. S., & Mauer, M. S. (2013) · Diabetes Care · doi:10.2337/dc12-2689 · Cited by 132 · see citing works
Plant-Derived Bioactive Peptides: A Treatment to Cure Diabetes
Patil, S. P., Goswami, A., Kalia, K., & Kate, A. S. (2019) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-019-09899-z · Cited by 129 · see citing works
Role of NFAT5 in Inflammatory Disorders Associated with Osmotic Stress
Neuhofer, W. (2010) · Current Genomics · doi:10.2174/138920210793360961 · Cited by 127 · see citing works
“In addition, oscillatory hyperglycemia as routinely found in most patients, causes more acute increases in plasma concentrations of pro-inflammatory cytokines including IL-6, IL-18, and TNF- , as compared to chronic hyperglycemia [60].”
Background
Frequent interruptions of sedentary time modulates contraction- and insulin-stimulated glucose uptake pathways in muscle: Ancillary analysis from randomized clinical trials
Bergouignan, A., Latouche, C., Heywood, S., Grace, M. S., Reddy-Luthmoodoo, M., Natoli, A. K., Owen, N., Dunstan, D. W., & Kingwell, B. A. (2016) · Scientific Reports · doi:10.1038/srep32044 · Cited by 121 · see citing works
Hypothesis: the “metabolic memory”, the new challenge of diabetes
Ceriello, A. (2009) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(09)70002-6 · Cited by 120 · see citing works
Self-citation
Self-Monitoring of Blood Glucose (SMBG) in Insulin- and Non–Insulin-Using Adults with Diabetes: Consensus Recommendations for Improving SMBG Accuracy, Utilization, and Research
Hirsch, I. B., Bode, B. W., Childs, B. P., Close, K. L., Fisher, W. A., Gavin, J. R., Ginsberg, B. H., Raine, C. H., & Verderese, C. A. (2008) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2008.0104 · Cited by 119 · see citing works
When basal insulin therapy in type 2 diabetes mellitus is not enough—what next?
Raccah, D., Bretzel, R. G., Owens, D. R., & Riddle, M. C. (2007) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.733 · Cited by 111 · see citing works
“However, physiological evidence suggests that rapid increments of glucose can have harmful effects on the vascular endothelium, perhaps mediated by an oxidative stress [27,28].”
Background
Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein
Watanabe, H., Inaba, Y., Kimura, K., Matsumoto, M., Kaneko, S., Kasuga, M., & Inoue, H. (2017) · Nature Communications · doi:10.1038/s41467-017-02537-6 · Cited by 104 · see citing works
Whole-Grain Processing and Glycemic Control in Type 2 Diabetes: A Randomized Crossover Trial
Åberg, S., Mann, J. I., Neumann, S., Ross, A. B., & Reynolds, A. N. (2020) · Diabetes Care · doi:10.2337/dc20-0263 · Cited by 107 · see citing works
The challenges of achieving postprandial glucose control using closed‐loop systems in patients with type 1 diabetes
Gingras, V., Taleb, N., Roy‐Fleming, A., Legault, L., & Rabasa‐Lhoret, R. (2018) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13052 · Cited by 113 · see citing works
“Controlling postprandial glucose excursions is identified as a key component of achieving a recommended HbA1c.2,18 The 2-hours post-meal glucose target in individuals with T1D is between 5 and 10 mmol/L in most patients.2,19 CHO content of meals is the main determinant of postprandial glucose excursion.20,21 Consequen…”
Dietary glycemic index and the risk of age-related macular degeneration
Kaushik, S., Wang, J. J., Flood, V. M., Tan, J. S. L., Barclay, A. W., Wong, T. Y., Brand-Miller, J. C., & Mitchell, P. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.4.1104 · Cited by 101 · see citing works
“Normal levels of glycemia tend to depress plasma antioxidant capacity (32) and hyperglycemia has been shown to generate oxidative stress (33–36).”
Background
Glucose-sensing microRNA-21 disrupts ROS homeostasis and impairs antioxidant responses in cellular glucose variability
Sala, L. L., Mrakic‐Sposta, S., Micheloni, S., Prattichizzo, F., & Ceriello, A. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0748-2 · Cited by 98 · see citing works
“Since GV is considered a strong predictor of the elevated risk of developing vascular complications [4, 5], even in non-diabetic subjects [6], it has attracted a great deal attention in clinical practice.”
BackgroundSelf-citation
Glycemic index, postprandial glycemia and cardiovascular disease
Dickinson, S. P., & Brand-Miller, J. C. (2005) · Current Opinion in Lipidology · doi:10.1097/00041433-200502000-00012 · Cited by 98 · see citing works
Postprandial glucose spikes, an important contributor to cardiovascular disease in diabetes?
Hanssen, N. M. J., Kraakman, M. J., Flynn, M. C., Nagareddy, P. R., Schalkwijk, C. G., & Murphy, A. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.570553 · Cited by 90 · see citing works
Acarbose: oral antidiabetes drug with additional cardiovascular benefits
Hanefeld, M., & Schaper, F. (2008) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.6.2.153 · Cited by 87 · see citing works
Eight-Point Glucose Testing Versus the Continuous Glucose Monitoring System in Evaluation of Glycemic Control in Type 1 Diabetes
The Diabetes Research in Children Network (DirecNet) Study Group (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2510 · Cited by 88 · see citing works
Effects of the brown rice diet on visceral obesity and endothelial function: the BRAVO study
Shimabukuro, M., Higa, M., Kinjo, R., Yamakawa, K., Tanaka, H., Kozuka, C., Yabiku, K., Taira, S.-I., Sata, M., & Masuzaki, H. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513002432 · Cited by 86 · see citing works
“glucose levels with macrovascular complications((11,14)).”
Background
The effect of continuous subcutaneous glucose monitoring (CGMS) versus intermittent whole blood finger-stick glucose monitoring (SBGM) on hemoglobin A1c (HBA1c) levels in Type I diabetic patients: A systematic review
Chetty, V. T., Almulla, A., Odueyungbo, A., & Thabane, L. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.02.014 · Cited by 85 · see citing works
GUIDELINES ON DIABETES, PRE-DIABETES, AND CARDIOVASCULAR DISEASES
Rydén, L., Standl, E., Bartnik, M., den Berghe, G. V., Betteridge, J. D., de Boer, M. J., Cosentino, F., Jönsson, B., Laakso, M., Malmberg, K., et al. (2007) · Rational Pharmacotherapy in Cardiology · doi:10.20996/1819-6446-2007-3-4-71-99 · Cited by 81 · see citing works
“The metabolic determinants and physiological bases of FPG and 2-hPG differ to some extent.(1,16,17) This means the categorization of an individual on a FPG value may differ from that based on a 2-hPG.”
Background
Acute Glucose Fluctuations and Chronic Sustained Hyperglycemia as Risk Factors for Cardiovascular Diseases in Patients with Type 2 Diabetes
Colette, C., & Monnier, L. (2007) · Hormone and Metabolic Research · doi:10.1055/s-2007-985157 · Cited by 81 · see citing works
Hyperglycemia during Induction Therapy is Associated with Poorer Survival in Children with Acute Lymphocytic Leukemia
Sonabend, R., McKay, S. V., Okcu, M. F., Yan, J., Haymond, M. W., & Margolin, J. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.01.072 · Cited by 81 · see citing works
Cutaneous Complications With Continuous or Flash Glucose Monitoring Use: Systematic Review of Trials and Observational Studies
Asarani, N. A. M., Reynolds, A. N., Styles, S. E., de Bock, M. I., & Wheeler, B. J. (2019) · Journal of Diabetes Science and Technology · doi:10.1177/1932296819870849 · Cited by 81 · see citing works
“Achieving healthy glycemic control is a critical goal for those with diabetes given the increased risk of both micro- and macrovascular complications.(1,2) Crucial to achieving this is frequent self-monitoring of glucose.”
Background
Impact of postprandial glucose control on diabetes-related complications: How is the evidence evolving?
Madsbad, S. (2015) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2015.09.019 · Cited by 78 · see citing works
“PPG is a key contributor to overall glycaemic control, and represents a primary target to improve HbA1c levels and, in turn, to reduce the vascular complications of diabetes [5-9].”
Background
The glycemic index and cardiovascular disease risk
Brand-Miller, J. C., Dickinson, S. P., Barclay, A. W., & Celermajer, D. S. (2007) · Current Atherosclerosis Reports · doi:10.1007/s11883-007-0064-x · Cited by 76 · see citing works
Optimizing Display, Analysis, Interpretation and Utility of Self-Monitoring of Blood Glucose (SMBG) Data for Management of Patients with Diabetes
Rodbard, D. (2007) · Journal of Diabetes Science and Technology · doi:10.1177/193229680700100111 · Cited by 74 · see citing works
Glycemic Index, Retinal Vascular Caliber, and Stroke Mortality
Kaushik, S., Wang, J. J., Wong, T. Y., Flood, V. M., Barclay, A. W., Brand-Miller, J. C., & Mitchell, P. (2008) · Stroke · doi:10.1161/strokeaha.108.513812 · Cited by 74 · see citing works
Acute hyperglycaemia rapidly increases arterial stiffness in young patients with type 1 diabetes
Gordin, D., Rönnback, M., Forsblom, C. M., Heikkilä, O., Saraheimo, M., & Groop, P. (2007) · Diabetologia · doi:10.1007/s00125-007-0730-0 · Cited by 73 · see citing works
“This, together with the observation of the effect of postprandial hyperglycaemia on HbA1c in patients with type 1 diabetes in the Diabetes Control and Complications Trial (DCCT) [41, 42], is an additional reason to strictly control daily blood glucose levels.”
Background
Sustained IL-1α, IL-4, and IL-6 elevations following correction of hyperglycemia in children with type 1 diabetes mellitus
Duque, J. S. R., Flores, R. L., Oliver, S. R., Pontello, A. M., Zaldivar, F. P., & Galassetti, P. R. (2008) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2007.00243.x · Cited by 71 · see citing works
Cardiovascular Disease in Diabetes Mellitus
Szuszkiewicz-Garcia, M., & Davidson, J. A. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.09.001 · Cited by 73 · see citing works
“tolerance test, as well as after a meal challenge, has proved to be a good predictor of cardiovascular events and mortality.(13) This relationship is linear.”
A Novel Analytical Method for Assessing Glucose Variability: Using CGMS in Type 1 Diabetes Mellitus
McCall, A. L., Cox, D. J., Crean, J., Gloster, M., & Kovatchev, B. P. (2006) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2006.8.644 · Cited by 72 · see citing works
Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: full text: The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD)
Authors Task Force Members, Rydén, L., Standl, E., Bartnik, M., den Berghe, G. V., Betteridge, J. D., de Boer, M., Cosentino, F., Jönsson, B., Laakso, M., et al. (2007) · European Heart Journal Supplements · doi:10.1093/eurheartj/ehl261 · Cited by 73 · see citing works
Atherogenicity of postprandial hyperglycemia and lipotoxicity
Ceriello, A., & Genovese, S. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9341-8 · Cited by 74 · see citing works
“and those in the general population [2].”
Self-citation
Synthesis of novel α-glucans with potential health benefits through controlled glucose release in the human gastrointestinal tract
Gangoiti, J., Corwin, S., Lamothe, L. M., Vafiadi, C., Hamaker, B. R., & Dijkhuizen, L. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1516621 · Cited by 69 · see citing works
Pramlintide in the Treatment of Diabetes Mellitus
Edelman, S. V., Maier, H., & Wilhelm, K. (2008) · BioDrugs · doi:10.2165/0063030-200822060-00004 · Cited by 68 · see citing works
DPP-4 inhibitors: pharmacological differences and their clinical implications
Ceriello, A., Sportiello, L., Rafaniello, C., & Rossi, F. (2014) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2014.944862 · Cited by 68 · see citing works
“Acute fluctuations of glucose more than chronic high glucose in the T2D individual have a harmful effect [82] through activation of oxidative stress at mitochondrial level [83].”
BackgroundSelf-citation
The Effect of Chromium Picolinate and Biotin Supplementation on Glycemic Control in Poorly Controlled Patients with Type 2 Diabetes Mellitus: A Placebo-Controlled, Double-Blinded, Randomized Trial
Singer, G. M., & Geohas, J. (2006) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2006.8.636 · Cited by 66 · see citing works
“18 Adverse effects of post-prandial hyperglycemia have been demonstrated.”
Carbohydrate restriction for diabetes: rediscovering centuries-old wisdom
Lennerz, B. S., Koutnik, A. P., Azova, S., Wolfsdorf, J. I., & Ludwig, D. S. (2021) · Journal of Clinical Investigation · doi:10.1172/jci142246 · Cited by 69 · see citing works
Exercise and 24-h Glycemic Control
van Dijk, J., MANDERS, R. J. F., Canfora, E. E., van Mechelen, W., Hartgens, F., Stehouwer, C. D. A., & van Loon, L. J. C. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31827ad8b4 · Cited by 65 · see citing works
Inhibitory effect of roasted/ unroasted Argania spinosa seeds oil on α- glucosidase, α-amylase and intestinal glucose absorption activities
Daoudi, N. E., Bouhrim, M., Ouassou, H., Legssyer, A., Mekhfi, H., Ziyyat, A., Aziz, M., & Bnouham, M. (2020) · South African Journal of Botany · doi:10.1016/j.sajb.2020.09.020 · Cited by 64 · see citing works
Continuous glucose monitoring in patients with type 2 diabetes: Why? When? Whom?
Monnier, L., Colette, C., Boegner, C., Pham, T. C., Lapinski, H., & Boniface, H. (2007) · Diabetes & Metabolism · doi:10.1016/j.diabet.2006.11.007 · Cited by 61 · see citing works
Glycemic Variability: Assessing Glycemia Differently and the Implications for Dietary Management of Diabetes
Tay, J., Thompson, C. H., & Brinkworth, G. D. (2015) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-121214-104422 · Cited by 62 · see citing works
“Recent evidence suggests that elevated PPG contributes to suboptimal glycemic control (4), has detrimental effects on CVD risk (51), and plays a significant role in the etiology of diabetes complications (238).”
Background
Safety and magnitude of changes in blood glucose levels following exercise performed in the fasted and the postprandial state in men with type 2 diabetes
Gaudet-Savard, T., Ferland, A., Broderick, T. L., Garneau, C., Tremblay, A., Nadeau, A., & Poirier, P. (2007) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e3282efaf38 · Cited by 60 · see citing works
Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia
Li, H., Wei, J., Lin, M., Smith, D. J., Vainio, J., Lin, C.-H., Chiang, F., Shih, S., Huang, C.-H., Wu, M.-Y., et al. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.03.041 · Cited by 57 · see citing works
Effects of S21403 (mitiglinide) on postprandial generation of oxidative stress and inflammation in type 2 diabetic patients
Assaloni, R., ROS, R. D., Quagliaro, L., Piconi, L., Maier, A., Zuodar, G., Motz, E., & Ceriello, A. (2005) · Diabetologia · doi:10.1007/s00125-005-1849-5 · Cited by 56 · see citing works
“Therefore, emerging evidence suggesting that the modulation of postprandial hyperglycaemia makes it possible to reduce these factors, which are very probably involved in the pathogenesis of CVD, seems to be of clinical interest and relevance.”
InfluentialSelf-citation
Hyperglycemia during induction therapy is associated with increased infectious complications in childhood acute lymphocytic leukemia
Sonabend, R., McKay, S. V., Okcu, M. F., Yan, J., Haymond, M. W., & Margolin, J. (2008) · Pediatric Blood & Cancer · doi:10.1002/pbc.21624 · Cited by 56 · see citing works
“Additionally, postprandial hyperglycemia has been shown to be a more powerful predictor of diabetic complications than glycosylated hemoglobin (HbA1c) and fasting hyperglycemia alone [24].”
Background
Importance of Postprandial Glucose in Relation to A1C and Cardiovascular Disease
Hershon, K. S., Hirsch, B. R., & Odugbesan, O. (2019) · Clinical Diabetes · doi:10.2337/cd18-0040 · Cited by 58 · see citing works
“Studies have shown that, in addition to its contribution to overall A1C, PPG is an independent risk factor for CVD, with a demonstrated linear relationship of PPG and risk of cardiovascular (CV) death (13).”
Background
Basal insulin or premix analogue therapy in type 2 diabetes patients
Raskin, P., Hollander, P. A., Lewin, A. J., Gabbay, R. A., Bode, B. W., & Garber, A. J. (2007) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2006.09.006 · Cited by 55 · see citing works
“Although not yet confirmed by prospective intervention trials, as recently reviewed by several authors, numerous observational studies have demonstrated that improved control of postprandial glucose is statistically associated with a significantly decreased risk of macrovascular [7–10] and microvascular [11] complicat…”
BackgroundResult
Relationships between glucose excursion and the activation of oxidative stress in patients with newly diagnosed type 2 diabetes or impaired glucose regulation
Zheng, F., Lu, W., Jia, C., Li, H., Wang, Z., & Jia, W. (2010) · Endocrine · doi:10.1007/s12020-009-9296-6 · Cited by 55 · see citing works
“The condition of chronic hyperglycemia can present in two different forms: sustained hyperglycemia and fluctuating hyperglycemia [ 4 , 5]. Glycated hemoglobin (HbA1c), an indicator of chronic sustained hyperglycemia, is the standard by which glycemic control is measured.”
Background
Inhibition of α‐Glucosidase, Intestinal Glucose Absorption, and Antidiabetic Properties by Caralluma europaea
Ouassou, H., Zahidi, T., Bouknana, S., Bouhrim, M., Mekhfi, H., Ziyyat, A., Legssyer, A., Aziz, M., & Bnouham, M. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/9589472 · Cited by 54 · see citing works
“Most epidemiological data implicate postprandial hyperglycemia in the development of chronic complications [8].”
Background
Evaluation of a simple policy for pre- and post-prandial blood glucose self-monitoring in people with type 2 diabetes not on insulin
Bonomo, K., De Salve, A., Fiora, E., Mularoni, E., Massucco, P., Poy, P., Pomero, A., Cavalot, F., Anfossi, G., & Trovati, M. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.10.021 · Cited by 53 · see citing works
Impact of Nutrient Type and Sequence on Glucose Tolerance: Physiological Insights and Therapeutic Implications
Nesti, L., Mengozzi, A., & Tricò, D. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00144 · Cited by 53 · see citing works
Haemoglobin A1c levels and subsequent cardiovascular disease in persons without diabetes: a meta-analysis of prospective cohorts
Santos‐Oliveira, R., Purdy, C., da Silva, M. P., Carneiro-Leão, A. M. D. A., Machado, M., & Einarson, T. R. (2011) · Diabetologia · doi:10.1007/s00125-011-2078-8 · Cited by 51 · see citing works
“However, despite the increasing number of studies of glycaemic control and CVEs, few have examined that relationship in persons without diabetes [1–8].”
Background
Phytochemical Analysis, α-Glucosidase and α-Amylase Inhibitory Activities and Acute Toxicity Studies of Extracts from Pomegranate (Punica granatum) Bark, a Valuable Agro-Industrial By-Product
Laaraj, N., Bouhrim, M., Kharchoufa, L., Tiji, S., Bendaha, H., Addi, M., Drouet, S., Hano, C., Lorenzo, J. M., Bnouham, M., et al. (2022) · Foods · doi:10.3390/foods11091353 · Cited by 50 · see citing works
“One of the treatments for decreasing postprandial hyperglycemia is related to the inhibition of digestive enzymes and the reduction in glucose intestinal absorption [5].”
Background
Exploring the Variability in Acute Glycemic Responses to Exercise in Type 2 Diabetes
Terada, T., Friesen, A., Chahal, B. S., Bell, G. J., McCargar, L. J., & Boulé, N. G. (2013) · Journal of Diabetes Research · doi:10.1155/2013/591574 · Cited by 50 · see citing works
“Given the possible pathogenic role postprandial hyperglycemia plays on the risk of diabetic complications [24, 25], performing exercise within 2 hours ofmeal intakemay be a good strategy to attenuate meal-induced hyperglycemia.”
Background
Dietary Glycemic Load Is a Predictor of Age-Related Hearing Loss in Older Adults ,
Gopinath, B., Flood, V. M., McMahon, C. M., Burlutsky, G., Brand-Miller, J. C., & Mitchell, P. L. R. (2010) · Journal of Nutrition · doi:10.3945/jn.110.128462 · Cited by 50 · see citing works
Relationship Between Diurnal Blood Pressure Variation and Diurnal Blood Glucose Levels in Type 2 Diabetic Patients
Pistrosch, F., Reissmann, E., Wildbrett, J., Koehler, C., & Markolf Hanefeld, E. (2007) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2006.10.010 · Cited by 49 · see citing works
What Do We Need beyond Hemoglobin A1c to Get the Complete Picture of Glycemia in People with Diabetes?
Hinzmann, R., Schlaeger, C., & Tran, C. T. (2012) · International Journal of Medical Sciences · doi:10.7150/ijms.4520 · Cited by 48 · see citing works
“The exposure to elevated blood glucose levels in people with diabetes involves two components: the duration and magnitude of chronically sustained hyperglycemia, reflected in HbA1c, and the acute fluctuations of glucose around a mean value from peaks to nadirs over a daily period [69-73], reflecting intermittent acute…”
Background
Peak-time determination of post-meal glucose excursions in insulin-treated diabetic patients
Daenen, S., Sola‐Gazagnes, A., M’Bemba, J., Dorange-Breillard, C., Defer, F., Elgrably, F., Larger, É., & Slama, G. (2010) · Diabetes & Metabolism · doi:10.1016/j.diabet.2009.12.002 · Cited by 49 · see citing works
Point: Postprandial Glucose Levels Are a Clinically Important Treatment Target
Ceriello, A. (2010) · Diabetes Care · doi:10.2337/dc10-0634 · Cited by 50 · see citing works
“pothesis (11), including the recent data of”
BackgroundSelf-citation
CGMS and Glycemic Variability, Relevance in Clinical Research to Evaluate Interventions in T2D, a Literature Review
Breyton, A.-E., Lambert-Porcheron, S., Laville, M., Vinoy, S., & Nazare, J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.666008 · Cited by 48 · see citing works
Insulin Aspart in the Management of Diabetes Mellitus: 15 Years of Clinical Experience
Hermansen, K., Bohl, M., & Schioldan, A. G. (2015) · Drugs · doi:10.1007/s40265-015-0500-0 · Cited by 46 · see citing works
“Some studies have indicated that postprandial glucose is a predictor of CVD or mortality independent of fasting glucose levels [19–24]; however, the current evidence for this is still highly controversial [25].”
Background
Antiinflammatory and ROS Suppressive Effects of the Addition of Fiber to a High-Fat High-Calorie Meal
Ghanim, H., Batra, M., Abuaysheh, S., Green, K., Makdissi, A., Kuhadiya, N. D., Chaudhuri, A., & Dandona, P. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2669 · Cited by 46 · see citing works
The Role of Molecular and Inflammatory Indicators in the Assessment of Cognitive Dysfunction in a Mouse Model of Diabetes
Piątkowska‐Chmiel, I., Herbet, M., Gawrońska‐Grzywacz, M., Ostrowska-Leśko, M., & Dudka, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083878 · Cited by 46 · see citing works
“High fasting glucose and insulin levels and high HOMA-IR index didn’t only confirm effective induction of experimental type 2 diabetes but also made it possible to observe CNS dysfunction widely described in the literature [6,7,11,13,49].”
Background
Control of plasma glucose with alpha-glucosidase inhibitor attenuates oxidative stress and slows the progression of heart failure in mice
Liao, Y., Takashima, S., ZHAO, H., ASANO, Y., Shintani, Y., Minamino, T., KIM, J., Fujita, M., HORI, M., & Kitakaze, M. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.01.021 · Cited by 45 · see citing works
Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load
Walsh, L. K., Restaino, R. M., Neuringer, M., Manrique, C. M., & Padilla, J. (2016) · Clinical Science · doi:10.1042/cs20160501 · Cited by 43 · see citing works
“It is well established that hyperglycemia is a major underlying contributor to cardiovascular disease (3, 12, 13, 14, 41, 51, 60, 63).”
Background
Cardiac cell death in early diabetes and its modulation by dietary fatty acids
Ghosh, S., & Rodrigues, B. B. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.08.010 · Cited by 43 · see citing works
Exercise-nutrient interactions for improved postprandial glycemic control and insulin sensitivity
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Authors: Ceriello, A.
Affiliations: University of Udine (IT)
Corresponding author: Ceriello, Antonio
ORCID: Ceriello, Antonio
Venue: Archives of Internal Medicine
Publisher: American Medical Association (AMA)
Published: 2004-10-25
Volume: 164
Issue: 19
Pages: 2090
ISSN: 0003-9926 (ISSN-L)
DOI: 10.1001/archinte.164.19.2090
OpenAlex: W2037632798
Cited by: 362
References: 52
Citations by year: 2026: 7 · 2025: 16 · 2024: 8 · 2023: 10 · 2022: 13 · 2021: 15 · 2020: 12 · 2019: 19 · 2018: 15 · 2017: 12 · 2016: 22 · 2015: 15 · 2014: 11 · 2013: 19 · 2012: 23
FWCI: 12.81
Type: journal article
Language: en
Open access: closed
Locations: Archives of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System (University of Udine) (submittedVersion)
STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: postprandial blood glucose, postprandial hyperglycemia, type 2 diabetes, cardiovascular complications, atherosclerosis, glycemic control, HbA1c, oxidative stress, endothelial cell cytotoxicity, glycemic exposure, cardiovascular risk prediction
MeSH terms: Blood Glucose, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Postprandial Period, Diabetes Complications

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Postprandial Glucose Regulation and Diabetic Complications

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