Induction of Drug Metabolism: The Role of Nuclear Receptors

The Peroxisome Proliferator Response Element of the Gene Encoding the Peroxisomal β-Oxidation Enzyme Enoyl-CoA Hydratase/3-Hydroxyacyl-CoA Dehydrogenase Is a Target for Constitutive Androstane Receptor β/9-cis-Retinoic Acid Receptor-mediated Transactivation

Kassam, A., Winrow, C. J., Fernandez-Rachubinski, F., Capone, J. P., & Rachubinski, R. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.6.4345 · Cited by 56

Bile acid and xenobiotic transporters in liver

Stieger, B., & Meier, P. J. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80059-8 · Cited by 56

Transcriptional response elements in the promoter of CYP6B1, an insect P450 gene regulated by plant chemicals

Petersen, R. A., Niamsup, H., Berenbaum, M. R., & Schuler, M. A. (2003) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00486-5 · Cited by 55

Nuclear Receptor Involvement in the Regulation of Rat Cytochrome P450 3A23 Expression

Huss, J. M., & Kasper, C. B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.26.16155 · Cited by 55

Protein Synthesis Inhibitors Exhibit a Nonspecific Effect on Phenobarbital-inducible Cytochome P450 Gene Expression in Primary Rat Hepatocytes

Sidhu, J. S., & Omiecinski, C. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.8.4769 · Cited by 55

Transcriptional Control of Hepatocanalicular Transporter Gene Expression

Müller, M. M. (2000) · Seminars in Liver Disease · doi:10.1055/s-2000-9387 · Cited by 55

Regulation of Hepatic Drug Metabolism: Role of the Nuclear Receptors PXR and CAR

Liddle, C., & Goodwin, B. J. (2002) · Seminars in Liver Disease · doi:10.1055/s-2002-30098 · Cited by 54

Pharmaceutical use of mouse models humanized for the xenobiotic receptor

Xie, W., & Evans, R. M. (2002) · Drug Discovery Today · doi:10.1016/s1359-6446(02)02251-1 · Cited by 52

Conservation of Signaling Pathways of Xenobiotic-Sensing Orphan Nuclear Receptors, Chicken Xenobiotic Receptor, Constitutive Androstane Receptor, and Pregnane X Receptor, from Birds to Humans

Handschin, C., Podvinec, M., Stöckli, J., Hoffmann, K. H., & Meyer, U. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.9.0701 · Cited by 51

Rabbit Pregnane X Receptor Is Activated by Rifampicin

Savas, Ü., Wester, M. R., Griffin, K. J., et al. (2000) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(24)15096-9 · Cited by 48

Squalestatin 1-Inducible Expression of Rat CYP2B: Evidence That an Endogenous Isoprenoid Is an Activator of the Constitutive Androstane Receptor

Kocarek, T. A., & Mercer-Haines, N. A. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.5.1177 · Cited by 47

Comparing nuclear receptors in worms, flies and humans

Enmark, E., & Gustafsson, J.-Α. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01859-9 · Cited by 45

Mechanism of induction of cytochrome p450 enzymes by the proestrogenic endocrine disruptor pesticide-methoxychlor: interactions of methoxychlor metabolites with the constitutive androstane receptor system.

Blizard, D. A., Sueyoshi, T., Negishi, M., Dehal, S. S., & Kupfer, D. (2001) · PubMed · Cited by 45

A Conserved Nuclear Receptor Consensus Sequence (DR-4) Mediates Transcriptional Activation of the Chicken CYP2H1 Gene by Phenobarbital in a Hepatoma Cell Line

Handschin, C., & Meyer, U. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.18.13362 · Cited by 43

Cytochromes P450 and flavin monooxygenases--targets and sources of nitric oxide.

Morgan, E. T., Ullrich, V., Daiber, A., Schmidt, P., Takaya, N., Shoun, H., McGiff, J. C., Oyekan, A., Hanke, C. J., Campbell, W. B., et al. (2001) · PubMed · Cited by 43

Regulation of Rat Hepatic Cytochrome P450 Expression by Sterol Biosynthesis Inhibition: Inhibitors of Squalene Synthase Are Potent Inducers of CYP2B Expression in Primary Cultured Rat Hepatocytes and Rat Liver

Kocarek, T. A., Kraniak, J. M., & Reddy, A. B. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.3.474 · Cited by 43

Controlling the glucose factory

Vidal‐Puig, A., & O’Rahilly, S. (2001) · Nature · doi:10.1038/35093198 · Cited by 42

Regulation of phenobarbital induction of the cytochrome P450 2b9/10 genes in primary mouse hepatocyte culture

Marc, N., Galisteo, M., Lagadic‐Gossmann, D., et al. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01083.x · Cited by 41

Effect of Phenobarbital on Hepatic CYP1A1 and CYP1A2 in the Ahr-Null Mouse

Zaher, H., Yang, T. J., Gelboin, H. V., Fernández‐Salguero, P. M., & Gonzalez, F. J. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00476-0 · Cited by 40

Benzoate X Receptors α and β Are Pharmacologically Distinct and Do Not Function as Xenobiotic Receptors

Grün, F., Venkatesan, R. N., Tabb, M. M., Zhou, C., Cao, J., Hemmati, D., & Blumberg, B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206553200 · Cited by 40

A model for the transcriptional regulation of the CYP2B1/B2 gene in rat liver.

Prabhu, L., Upadhya, P., Ram, N. V. R., Nirodi, C. S., Sultana, S., Vatsala, P. G., Mani, S. A., Rangarajan, P. N., Surolia, A., & Padmanaban, G. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9628 · Cited by 39

Phenobarbital responsiveness conferred by the 5′-flanking region of the rat CYP2B2 gene in transgenic mice

Ramsden, R., Beck, N. B., Sommer, K. M., & Omiecinski, C. J. (1999) · Gene · doi:10.1016/s0378-1119(98)00612-x · Cited by 38

Phosphorylation/Dephosphorylation Steps Are Crucial for the Induction of CYP2B1 and CYP2B2 Gene Expression by Phenobarbital

Kawamura, A., Yoshida, Y., Kimura, N., Oda, H., & Kakinuma, A. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1544 · Cited by 38

Gene Induction by Phenobarbital: An Update on an Old Question that Receives Key Novel Answers

Corcos, L., & Lagadic‐Gossmann, D. (2001) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2001.d01-144.x · Cited by 37

Regulation of Cytochrome P450 Gene Transcription by Phenobarbital

KEMPER, B. W. (1998) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60824-7 · Cited by 35

Divergent effects of cycloheximide on the induction of Class II and Class III cytochrome P450 mRNAs in cultures of adult rat hepatocytes

Burger, H.-J., Schuetz, E. G., Schuetz, J. D., & Guzelian, P. S. (1990) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(90)90433-y · Cited by 35

Microsomal ethanol oxidizing system: transcriptional and posttranscriptional regulation of cytochrome P450, CYP2E1.

Gonzalez, F. J., Ueno, T., Umeno, M., Song, B. J., Veech, R. L., & Gelboin, H. V. (1991) · PubMed · Cited by 34

Phenobarbital Induction of CYP2B1/2 in Primary Hepatocytes: Endocrine Regulation and Evidence for a Single Pathway for Multiple Inducers

Ganem, L. G., Trottier, E., Anderson, A., & Jefcoate, C. R. E. (1999) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1998.8599 · Cited by 32

Expression and Replication Timing Patterns of Wildtype and Translocated BCL2 Genes

Sun, Y., Wyatt, R. T., Bigley, A., & Krontiris, T. G. (2001) · Genomics · doi:10.1006/geno.2000.6479 · Cited by 32

Nuclear Receptors Orchestrate Detoxification Pathways

Roy‐Chowdhury, J., Locker, J. D., & Roy‐Chowdhury, N. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00131-x · Cited by 30

Use of dominant negative nuclear receptors to study xenobiotic-inducible gene expression in primary cultured hepatocytes

Kocarek, T. A., Shenoy, S. D., Mercer-Haines, N. A., & Runge‐Morris, M. (2002) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/s1056-8719(03)00002-9 · Cited by 30

A component of the 26S proteasome binds an orphan member of the nuclear hormone receptor superfamily

Choi, H., Seol, W., & Moore, D. D. (1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00220-0 · Cited by 25

The PXR crystal structure: the end of the beginning

Ekins, S., & Schuetz, E. G. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)01977-6 · Cited by 24

Retinoic Acids Repress Constitutive Active Receptor-Mediated Induction by 1,4-bis[2-(3,5-Dichloropyridyloxy)]benzene of the Cyp2b10 Gene in Mouse Primary Hepatocytes

Kakizaki, S., Karami, S., & Negishi, M. (2002) · Drug Metabolism and Disposition · doi:10.1124/dmd.30.2.208 · Cited by 22

A Link between Cholesterol Levels and Phenobarbital Induction of Cytochromes P450

Ourlin, J.-C., Handschin, C., Kaufmann, M., & Meyer, U. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6464 · Cited by 21

Involvement of Cyclic Nucleotide- and Calcium-Regulated Pathways in Phenobarbital-Induced Cytochrome P-450 3A Expression in Mouse Primary Hepatocytes

Galisteo, M., Marc, N., Fautrel, A., Guillouzo, A., Corcos, L., & Lagadic‐Gossmann, D. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35031-1 · Cited by 21

Transcriptional analysis in vivo of the hepatic genes, Cyp2b9 and Cyp2b10, by intravenous administration of plasmid DNA in mice

Rivera-Rivera, I. D., Kim, J., & KEMPER, B. W. (2003) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00484-1 · Cited by 20

A 65-kDa Protein Mediates the Positive Role of Heme in Regulating the Transcription of CYP2B1/B2 Gene in Rat Liver

Sultana, S., Nirodi, C. S., Ram, N. V. R., Prabhu, L., & Padmanaban, G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.14.8895 · Cited by 18

Molecular Cloning and Functional Characterization of a Novel Nuclear Receptor Similar to an Embryonic Benzoate Receptor BXR

Nishikawa, J.-I., Saito, K., Sasaki, M., Tomigahara, Y., & Nishihara, T. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3649 · Cited by 15

Positive regulation of the rat CYP2B2 phenobarbital response unit by the nuclear receptor hexamer half-site·nuclear factor 1 complex

Stoltz, C. M., & Anderson, A. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00367-0 · Cited by 10

The PXR ligand-binding domain: how to be picky and promiscuous at the same time

Gillam, E. M. J. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01847-2 · Cited by 9

Evidence That the Coactivator CBP/p300 Is Important for Phenobarbital-Induced but Not Basal Expression of the CYP2H1 Gene

Dogra, S. C., Tremethick, D. J., & May, B. K. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.1.73 · Cited by 3

Cytochrome P450 Enzymes and Drug Metabolism in Humans

Zhao, M., Ma, J., Li, M., Zhang, Y., Jiang, B., Zhao, X., Huai, C., Shen, L., Zhang, N., He, L., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312808 · Cited by 1,070

Sex Differences in the Expression of Hepatic Drug Metabolizing Enzymes

Waxman, D. J., & Holloway, M. G. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.056705 · Cited by 815

Circadian Rhythms: Mechanisms and Therapeutic Implications

Levi, F., & Schibler, U. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105208 · Cited by 645

CYP induction-mediated drug interactions: in vitro assessment and clinical implications

Lin, J. H. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-0277-7 · Cited by 264

Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism

Eloranta, J. J., & Kullak-Ublick, G. A. (2005) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.09.019 · Cited by 260