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Induction of Drug Metabolism: The Role of Nuclear Receptors
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Cites
The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
The RXR heterodimers and orphan receptors
Mangelsdorf, D. J., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90200-7 · Cited by 3,158
P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature
Nelson, D. R., Koymans, L., Kamataki, T., Stegeman, J. J., Feyereisen, R., Waxman, D. J., Waterman, M. R., Gotoh, O., Coon, M. J., Estabrook, R. W., et al. (1996) · Pharmacogenetics · doi:10.1097/00008571-199602000-00002 · Cited by 2,945
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546
Nuclear Receptors and Lipid Physiology: Opening the X-Files
Chawla, A., Repa, J. J., Evans, R. M., & Mangelsdorf, D. J. (2001) · Science · doi:10.1126/science.294.5548.1866 · Cited by 2,085
Puigserver, P., & Spiegelman, B. M. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0012 · Cited by 2,076
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00051-4 · Cited by 1,940
Steroid hormone receptors: Many Actors in search of a plot
Beato, M., Herrlich, P., & Schütz, G. (1995) · Cell · doi:10.1016/0092-8674(95)90201-5 · Cited by 1,823
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
Yoon, J. C., Puigserver, P., Chen, G., Donovan, J., Wu, Z., Rhee, J., Adelmant, G., Stafford, J., Kahn, C. R., Granner, D. K., et al. (2001) · Nature · doi:10.1038/35093050 · Cited by 1,821
The Aryl Hydrocarbon Receptor Complex
Hankinson, O. (1995) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.35.040195.001515 · Cited by 1,649 · cited 1×
“These findings, in addition to the discovery of AhR-response elements in the flanking regions of CYP1As were the basis for further characterization of this mechanism (Hankinson, 1995; Whitlock, 1999; Ma, 2001).”
Towards a molecular understanding of adaptive thermogenesis
Lowell, B. B., & Spiegelman, B. M. (2000) · Nature · doi:10.1038/35007527 · Cited by 1,630
The Liver: Biology and Pathobiology.
(1983) · Annals of Internal Medicine · doi:10.7326/0003-4819-98-5-690_3 · Cited by 1,590
P450 GENES: STRUCTURE, EVOLUTION, AND REGULATION
Nebert, D. W., & Gonzalez, F. J. (1987) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.56.070187.004501 · Cited by 1,585
Lehmann, J. M., McKee, D. D., Watson, M. A., Willson, T. M., Moore, J. T., & Kliewer, S. A. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3703 · Cited by 1,576
An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway
Kliewer, S. A., Moore, J. T., Wade, L., Staudinger, J. L., Watson, M. A., Jones, S. A., McKee, D. D., Oliver, B. B., Willson, T. M., Zetterström, R. H., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80900-9 · Cited by 1,539
Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors
Lu, T. T., Makishima, M., Repa, J. J., Schoonjans, K., Kerr, T. A., Auwerx, J., & Mangelsdorf, D. J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00050-2 · Cited by 1,487
Clinical importance of the cytochromes P450
Nebert, D. W., & Russell, D. W. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11203-7 · Cited by 1,414
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
Staudinger, J. L., Goodwin, B., Jones, S. A., Hawkins-Brown, D., MacKenzie, K. I., LaTour, A., Liu, Y., Klaassen, C. D., Brown, K. K., Reinhard, J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051551698 · Cited by 1,379
A unified nomenclature system for the nuclear receptor superfamily
(1999) · Cell · doi:10.1016/s0092-8674(00)80726-6 · Cited by 1,208
INDUCTION OF CYTOCHROME P4501A1
Whitlock, J. P. (1999) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.39.1.103 · Cited by 1,124
Feyereisen, R. (1999) · Annual Review of Entomology · doi:10.1146/annurev.ento.44.1.507 · Cited by 1,067
Cytochromes P450: a success story.
Werck‐Reichhart, D., & Feyereisen, R. (2000) · Genome biology · doi:10.1186/gb-2000-1-6-reviews3003 · Cited by 1,004
Genetic contribution to variable human CYP3A-mediated metabolism
Lamba, J. K., Lin, Y. S., Schuetz, E. G., & Thummel, K. E. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00066-2 · Cited by 990
St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
Moore, L. B., Goodwin, B., Jones, S. A., Wisely, G. B., Serabjit-Singh, C. J., Willson, T. M., Collins, J. L., & Kliewer, S. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.130155097 · Cited by 947
The Nuclear Pregnane X Receptor: A Key Regulator of Xenobiotic Metabolism
Kliewer, S. A., Goodwin, B., & Willson, T. M. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0038 · Cited by 921
SXR, a novel steroid and xenobioticsensing nuclear receptor
Blumberg, B., Sabbagh, W., Juguilon, H., Bolado, J., van Meter, C. M., Ong, E. S., & Evans, R. M. (1998) · Genes & Development · doi:10.1101/gad.12.20.3195 · Cited by 919
Kast, H. R., Goodwin, B., Tarr, P. T., Jones, S. A., Anisfeld, A. M., Stoltz, C. M., Tontonoz, P., Kliewer, S., Willson, T. M., & Edwards, P. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109326200 · Cited by 916
Cytochrome P-4502E1: its physiological and pathological role
Lieber, C. S. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.2.517 · Cited by 889
Identification of a human nuclear receptor defines a new signaling pathway for CYP 3 A induction
Bertilsson, G., Heidrich, J., Svensson, K., Åsman, M., Jendeberg, L., Sydow-Bäckman, M., Ohlsson, R., Postlind, H., Blomquist, P., & Berkenstam, A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12208 · Cited by 872
A Single P450 Allele Associated with Insecticide Resistance in Drosophila
Daborn, P. J., Yen, J. L., Bogwitz, M. R., Le Goff, G., Feil, E., Jeffers, S., Tijet, N., Perry, T., Heckel, D., Batterham, P., et al. (2002) · Science · doi:10.1126/science.1074170 · Cited by 849
Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin
Geick, A., Eichelbaum, M., & Burk, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010173200 · Cited by 848
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
Synold, T. W., Dussault, I., & Forman, B. M. (2001) · Nature Medicine · doi:10.1038/87912 · Cited by 840
Moore, L. B., Parks, D. J., Jones, S. A., Bledsoe, R. K., Consler, T. G., Stimmel, J. B., Goodwin, B., Liddle, C., Blanchard, S. G., Willson, T. M., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001215200 · Cited by 815
The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity
Watkins, R. E., Wisely, G. B., Moore, L. B., Collins, J. L., Lambert, M. H., Williams, S. P., Willson, T. M., Kliewer, S. A., & Redinbo, M. R. (2001) · Science · doi:10.1126/science.1060762 · Cited by 760
The Role of Orphan Nuclear Receptors in the Regulation of Cholesterol Homeostasis
Repa, J. J., & Mangelsdorf, D. J. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.459 · Cited by 759
An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids
Xie, W., Radominska-Pandya, A., Shi, Y., Simon, C. M., Nelson, M. C., Ong, E. S., Waxman, D. J., & Evans, R. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051014398 · Cited by 757
Waxman, D. J. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1351 · Cited by 753
Honkakoski, P., Zelko, I., Sueyoshi, T., & Negishi, M. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.10.5652 · Cited by 700
The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution
Jones, S. A., Moore, L. B., Shenk, J. L., Wisely, G. B., Hamilton, G. A., McKee, D. D., Tomkinson, N. C. O., LeCluyse, E. L., Lambert, M. H., Willson, T. M., et al. (2000) · Molecular Endocrinology · doi:10.1210/me.14.1.27 · Cited by 672
The Repressed Nuclear Receptor CAR Responds to Phenobarbital in Activating the Human CYP2B6 Gene
Sueyoshi, T., Kawamoto, T., Zelko, I., Honkakoski, P., & Negishi, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6043 · Cited by 668
Evolution of Supergene Families Associated with Insecticide Resistance
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J., Sharakhova, M. V., Unger, M. F., Collins, F. H., & Feyereisen, R. (2002) · Science · doi:10.1126/science.1076781 · Cited by 666
Humanized xenobiotic response in mice expressing nuclear receptor SXR
Xie, W., Barwick, J. L., Downes, M., Blumberg, B., Simon, C. M., Nelson, M. C., Neuschwander-Tetri, B. A., Brunt, E. M., Guzelian, P. S., & Evans, R. M. (2000) · Nature · doi:10.1038/35019116 · Cited by 660
The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
Wei, P., Zhang, J., Egan-Hafley, M., Liang, S., & Moore, D. D. (2000) · Nature · doi:10.1038/35038112 · Cited by 654
Maglich, J. M., Stoltz, C. M., Goodwin, B., Hawkins-Brown, D., Moore, J. T., & Kliewer, S. A. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.3.638 · Cited by 654
Goodwin, B., Hodgson, E., & Liddle, C. (1999) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12400-5 · Cited by 646
Enzyme induction in the cytochrome P-450 system
Okey, A. B. (1990) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(90)90030-6 · Cited by 625
Pharmacogenetics and adverse drug reactions
Meyer, U. A. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03167-6 · Cited by 602
Self-citationMOLECULAR MECHANISMS OF GENETIC POLYMORPHISMS OF DRUG METABOLISM
Meyer, U. A., & Zanger, U. M. (1997) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.269 · Cited by 549
Self-citationPhenobarbital-Responsive Nuclear Translocation of the Receptor CAR in Induction of the CYP2B Gene
Kawamoto, T., Sueyoshi, T., Zelko, I., Moore, R., Washburn, K., & Negishi, M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.6318 · Cited by 549
Seol, W., Choi, H.-S., & Moore, D. D. (1996) · Science · doi:10.1126/science.272.5266.1336 · Cited by 534
ADAPTIVE INCREASES IN DRUG-METABOLIZING ENZYMES INDUCED BY PHENOBARBITAL AND OTHER DRUGS
Conney, A. H., Davison, C., Gastel, R., & Burns, J. J. (1960) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)25856-6 · Cited by 533
Phenobarbital induction of cytochrome P-450 gene expression
Waxman, D. J., & Azaroff, L. (1992) · Biochemical Journal · doi:10.1042/bj2810577 · Cited by 532
Coregulator codes of transcriptional regulation by nuclear receptors
Rosenfeld, M. G., & Glass, C. K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100041200 · Cited by 509
Reciprocal activation of Xenobiotic response genes by nuclear receptors SXR/PXR and CAR
Xie, W., Barwick, J. L., Simon, C. M., Pierce, A. M., Safe, S., Blumberg, B., Guzelian, P. S., & Evans, R. M. (2000) · Genes & Development · doi:10.1101/gad.846800 · Cited by 508
Regulation of cytochrome P450 (CYP) genes by nuclear receptors
Honkakoski, P., & Negishi, M. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3470321 · Cited by 501
Baes, M., Gulick, T., Choi, H. S., Martinoli, M. G., Simha, D., & Moore, D. D. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.1544 · Cited by 494
Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.
(2000) · PubMed Central · Cited by 489
Androstane metabolites bind to and deactivate the nuclear receptor CAR-β
Forman, B. M., Tzameli, I., Choi, H.-S., Chen, J., Simha, D., Seol, W., Evans, R. M., & Moore, D. D. (1998) · Nature · doi:10.1038/26996 · Cited by 476
Redundant Pathways for Negative Feedback Regulation of Bile Acid Production
Wang, L., Lee, Y.-K., Bundman, D., Han, Y., Thevananther, S., Kim, C.-S., Chua, S. S., Wei, P., Heyman, R. A., Karin, M., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00187-9 · Cited by 476
Ueda, A., Hamadeh, H. K., Webb, H. K., Yamamoto, Y., Sueyoshi, T., Afshari, C. A., Lehmann, J. M., & Negishi, M. (2002) · Molecular Pharmacology · doi:10.1124/mol.61.1.1 · Cited by 466
Mammalian hepatocyte differentiation requires the transcription factor HNF-4α
Li, J., Ning, G., & Duncan, S. A. (2000) · Genes & Development · doi:10.1101/gad.14.4.464 · Cited by 458
The orphan nuclear receptor HNF4α determines PXR- and CAR-mediated xenobiotic induction of CYP3A4
Tirona, R. G., Lee, W., Leake, B. F., Lan, L.-B., Cline, C. B., Lamba, V., Parviz, F., Duncan, S. A., Inoue, Y., Gonzalez, F. J., et al. (2003) · Nature Medicine · doi:10.1038/nm815 · Cited by 440
Maglich, J. M., Parks, D. J., Moore, L. B., Collins, J. L., Goodwin, B., Billin, A. N., Stoltz, C. A., Kliewer, S. A., Lambert, M. H., Willson, T. M., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300138200 · Cited by 416
Tzameli, I., Pissios, P., Schuetz, E. G., & Moore, D. D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.9.2951-2958.2000 · Cited by 408
Interactions of Herbs with Cytochrome P450
Zhou, S., Gao, Y., Jiang, W., Huang, M., Xu, A., & Paxton, J. W. (2003) · Drug Metabolism Reviews · doi:10.1081/dmr-120018248 · Cited by 397
Induction of bilirubin clearance by the constitutive androstane receptor (CAR)
Huang, W., Zhang, J., Chua, S. S., Qatanani, M., Han, Y., Granata, R., & Moore, D. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630614100 · Cited by 390
Sugatani, J., Kojima, H., Ueda, A., Kakizaki, S., Yoshinari, K., Gong, Q.-H., Owens, I. S., Negishi, M., & Sueyoshi, T. (2001) · Hepatology · doi:10.1053/jhep.2001.24172 · Cited by 381
Regulation of the Human CYP2B6 Gene by the Nuclear Pregnane X Receptor
Goodwin, B., Moore, L. B., Stoltz, C. M., McKee, D. D., & Kliewer, S. A. (2001) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12603-x · Cited by 374
Pascussi, J.-M., Drocourt, L., Fabre, J.-M., Maurel, P., & Vilarem, M.-J. (2000) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12072-x · Cited by 372
Xie, W., Yeuh, M.-F., Radominska-Pandya, A., Saini, S. P. S., Negishi, Y., Bottroff, B. S., Cabrera, G. Y., Tukey, R. H., & Evans, R. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0438010100 · Cited by 367
Phenobarbital Response Elements of Cytochrome P450 Genes and Nuclear Receptors
Sueyoshi, T., & Negishi, M. (2001) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.123 · Cited by 362
Drocourt, L., Ourlin, J.-C., Pascussi, J.-M., Maurel, P., & Vilarem, M.-J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201323200 · Cited by 356
Moore, L. B., Maglich, J. M., McKee, D. D., Wisely, B., Willson, T. M., Kliewer, S. A., Lambert, M. H., & Moore, J. T. (2002) · Molecular Endocrinology · doi:10.1210/me.16.5.977 · Cited by 355
Xenobiotic-inducible Transcription of Cytochrome P450 Genes
Denison, M. S., & Whitlock, J. P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.31.18175 · Cited by 354
Kerr, T. A., Saeki, S., Schneider, M., Schaefer, K., Berdy, S., Redder, T., Shan, B., Russell, D. W., & Schwarz, M. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00154-5 · Cited by 351
Schuetz, E. G., Strom, S., Yasuda, K., Lecureur, V., Assem, M., Brimer, C., Lamba, J., Kim, R. B., Ramachandran, V., Komoroski, B. J., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106340200 · Cited by 334
Pascussi, J. M., Gerbal-Chaloin, S., Drocourt, L., Maurel, P., & Vilarem, M. J. (2003) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00483-x · Cited by 330
Sharp, an inducible cofactor that integrates nuclear receptor repression and activation
Shi, Y., Downes, M., Xie, W., Kao, H.-Y., Ordentlich, P., Tsai, C.-C., Hon, M., & Evans, R. M. (2001) · Genes & Development · doi:10.1101/gad.871201 · Cited by 329
Regulation of CYP3A Gene Transcription by the Pregnane X Receptor
Goodwin, B., Redinbo, M. R., & Kliewer, S. A. (2002) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.42.111901.111051 · Cited by 327
Transcriptional Control of Intestinal Cytochrome P-4503A by 1α,25-Dihydroxy Vitamin D3
Thummel, K. E., Brimer, C., Yasuda, K., Thottassery, J., Senn, T., Lin, Y., Ishizuka, H., Kharasch, E., Schuetz, J., & Schuetz, E. (2001) · Molecular Pharmacology · doi:10.1124/mol.60.6.1399 · Cited by 325
Nuclear receptor coregulators: multiple modes of modification
Hermanson, O., Glass, C. K., & Rosenfeld, M. G. (2002) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(01)00527-6 · Cited by 322
2.1 Å Crystal Structure of Human PXR in Complex with the St. John's Wort Compound Hyperforin,
Watkins, R. E., Maglich, J. M., Moore, L. B., Wisely, G. B., Noble, S. M., Davis-Searles, P. R., Lambert, M. H., Kliewer, S. A., & Redinbo, M. R. (2003) · Biochemistry · doi:10.1021/bi0268753 · Cited by 319
Modulation of Acetaminophen-Induced Hepatotoxicity by the Xenobiotic Receptor CAR
Zhang, J., Huang, W., Chua, S. S., Wei, P., & Moore, D. D. (2002) · Science · doi:10.1126/science.1073502 · Cited by 316
Lee, Y.-K., Dell, H., Dowhan, D. H., Hadzopoulou-Cladaras, M., & Moore, D. D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.1.187-195.2000 · Cited by 308
Hnf4: A Central Regulator of Hepatocyte Differentiation and Function
Watt, A. J., Garrison, W. D., & Duncan, S. A. (2003) · Hepatology · doi:10.1053/jhep.2003.50273 · Cited by 307
Pascussi, J., Drocourt, L., Gerbal‐Chaloin, S., Fabre, J., Maurel, P., & Vilarem, M. (2001) · European Journal of Biochemistry · doi:10.1046/j.0014-2956.2001.02540.x · Cited by 302
Orphan nuclear receptors—new ligands and new possibilities: Figure 1.
Blumberg, B., & Evans, R. M. (1998) · Genes & Development · doi:10.1101/gad.12.20.3149 · Cited by 301
The cytochrome P450 4 (CYP4) family
Simpson, A. E. C. M. (1997) · General Pharmacology: The Vascular System · doi:10.1016/s0306-3623(96)00246-7 · Cited by 298
Zhang, J., Kuehl, P., Green, E. D., Touchman, J. W., Watkins, P. B., Daly, A., Hall, S. D., Maurel, P., Relling, M., Brimer, C., et al. (2001) · Pharmacogenetics · doi:10.1097/00008571-200110000-00003 · Cited by 292
Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR)
Sonoda, J., Xie, W., Rosenfeld, J. M., Barwick, J. L., Guzelian, P. S., & Evans, R. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212494599 · Cited by 281
Overview of enzymes of drug metabolism
Meyer, U. A. (1996) · Journal of Pharmacokinetics and Biopharmaceutics · doi:10.1007/bf02353473 · Cited by 279
Self-citationDifferential Transactivation by Two Isoforms of the Orphan Nuclear Hormone Receptor CAR
Choi, H.-S., Chung, M., Tzameli, I., Simha, D., Lee, Y.-K., Seol, W., & Moore, D. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.23565 · Cited by 279
Transcriptional Regulation of CYP2C9 Gene
Gerbal-Chaloin, S., Daujat, M., Pascussi, J.-M., Pichard-Garcia, L., Vilarem, M.-J., & Maurel, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107228200 · Cited by 262
Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor.
Staudinger, J. L., Liu, Y., Madan, A., Habeebu, S. S., & Klaassen, C. D. (2001) · PubMed · Cited by 260
Transcriptional Regulation of the Human CYP3A4Gene by the Constitutive Androstane Receptor
Goodwin, B., Hodgson, E., D'Costa, D. J., Robertson, G. R., & Liddle, C. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.2.359 · Cited by 254
Pascussi, J.-M., Gerbal-Chaloin, S., Fabre, J.-M., Maurel, P., & Vilarem, M.-J. (2000) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12718-6 · Cited by 253
Regulation of CYP3A4 Expression in Human Hepatocytes by Pharmaceuticals and Natural Products
Raucy, J. L. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.5.533 · Cited by 249
Wei, P., Zhang, J., Dowhan, D. H., Han, Y., & Moore, D. D. (2002) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500087 · Cited by 240
Vitamin E activates gene expression via the pregnane X receptor
Landes�, N., Pfluger, P. T., Kluth�, D., Birringer, M., Rühl, R., Böl, G., Glatt, H. R., & Brigelius‐Flohé, R. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01520-4 · Cited by 236
St John's wort, a herbal antidepressant, activates the steroid X receptor
Wentworth, J., Agostini, M., Love, J., Schwabe, J., & Chatterjee, V. (2000) · Journal of Endocrinology · doi:10.1677/joe.0.166r011 · Cited by 236
Ma, Q. (2001) · Current Drug Metabolism · doi:10.2174/1389200013338603 · Cited by 232
Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor
Kliewer, S. A., & Willson, T. M. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30141-3 · Cited by 232
Pascussi, J.-M., Gerbal-Chaloin, S., Pichard-Garcia, L., Daujat, M., Fabre, J.-M., Maurel, P., & Vilarem, M.-J. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3219 · Cited by 231
Wan, Y.-J. Y., An, D., Cai, Y., Repa, J. J., Hung-Po Chen, T., Flores, M., Postic, C., Magnuson, M. A., Chen, J., Chien, K. R., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.12.4436-4444.2000 · Cited by 228
Rosenfeld, J. M., Vargas, R., Xie, W., & Evans, R. M. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0421 · Cited by 224
The Acute Phase Response Is Associated with Retinoid X Receptor Repression in Rodent Liver
Beigneux, A. P., Moser, A. H., Shigenaga, J. K., Grunfeld, C., & Feingold, K. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000953200 · Cited by 223
Remmer, H., & Merker, H. J. (1963) · Klinische Wochenschrift · doi:10.1007/bf01483392 · Cited by 222
Jover, R., Bort, R., Gómez‐Lechón, M. J., & Castell, J. V. (2002) · The FASEB Journal · doi:10.1096/fj.02-0195fje · Cited by 221
Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4.
Hustert, E., Zibat, A., Presecan, E., Eiselt, R., Mueller, R., Fuss, C., Brehm, I., Brinkmann, U., Eichelbaum, M. F., Wojnowski, L., et al. (2001) · PubMed · Cited by 218
Wang, H., Faucette, S., Sueyoshi, T., Moore, R., Ferguson, S., Negishi, M., & LeCluyse, E. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212482200 · Cited by 215
Cherrington, N. J., Hartley, D. P., Li, N., Johnson, D. R., & Klaassen, C. D. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.1.97 · Cited by 212
Orphan Nuclear Receptors: The Exotics of Xenobiotics
Xie, W., & Evans, R. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100033200 · Cited by 210
Orphan nuclear receptors--the first eight years.
Enmark, E., & Gustafsson, J.-Α. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.11.8923456 · Cited by 207
Rat Pregnane X Receptor: Molecular Cloning, Tissue Distribution, and Xenobiotic Regulation
Zhang, H., LeCulyse, E., Liu, L., Hu, M., Matoney, L., Zhu, W., & Yan, B. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1307 · Cited by 205
Masuyama, H., Hiramatsu, Y., Kunitomi, M., Kudo, T., & MacDonald, P. N. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.3.0424 · Cited by 202
Goodwin, B., Gauthier, K. C., Umetani, M., Watson, M. A., Lochansky, M. I., Collins, J. L., Leitersdorf, E., Mangelsdorf, D. J., Kliewer, S. A., & Repa, J. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0237082100 · Cited by 198
Beigneux, A. P., Moser, A. H., Shigenaga, J. K., Grunfeld, C., & Feingold, K. R. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00196-1 · Cited by 192
Peptide Mimetic HIV Protease Inhibitors Are Ligands for the Orphan Receptor SXR
Dussault, I., Lin, M., Hollister, K., Wang, E. H., Synold, T. W., & Forman, B. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100375200 · Cited by 189
NUBIScan, an in Silico Approach for Prediction of Nuclear Receptor Response Elements
Podvinec, M., Kaufmann, M. R., Handschin, C., & Meyer, U. A. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.6.0851 · Cited by 186
Self-citationMolecular Mechanisms of Polymorphic CYP3A7 Expression in Adult Human Liver and Intestine
Burk, O., Tegude, H., Koch, I., Hustert, E., Wolbold, R., Glaeser, H., Klein, K., Fromm, M. F., Nuessler, A. K., Neuhaus, P., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202345200 · Cited by 185
Bulera, S. J., Eddy, S. M., Ferguson, E., Jatkoe, T. A., Reindel, J. F., Bleavins, M. R., & de la Iglesia, F. A. (2001) · Hepatology · doi:10.1053/jhep.2001.23560 · Cited by 182
Huang, S. M. (2004) · Springer eBooks · doi:10.1007/978-1-4419-9216-1_10 · Cited by 180
Drug-activated nuclear receptors CAR and PXR
Honkakoski, P., Sueyoshi, T., & Negishi, M. (2003) · Annals of Medicine · doi:10.1080/07853890310008224 · Cited by 180
Role of the peroxisome proliferator‐activated receptor in cytochrome P450 4A gene regulation
Johnson, E. F., Palmer, C. N. A., Griffin, K. J., & Hsu, M. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.11.8836037 · Cited by 177
P450BM-3 and other Inducible Bacterial P450 Cytochromes: Biochemistry and Regulation
Fulco, A. J. (1991) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.31.040191.001141 · Cited by 175
Nuclear receptor regulation of hepatic function
Karpen, S. J. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00129-0 · Cited by 174
Waxman, D. J., Morrissey, J. J., Naik, S., & Jauregui, H. O. (1990) · Biochemical Journal · doi:10.1042/bj2710113 · Cited by 170
Kawamoto, T., Kakizaki, S., Yoshinari, K., & Negishi, M. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.11.0547 · Cited by 168
Cyp3A regulation: from pharmacology to nuclear receptors.
Quattrochi, L. C., & Guzelian, P. S. (2001) · PubMed · Cited by 162
Honkakoski, P., Moore, R., Washburn, K. A., & Negishi, M. (1998) · Molecular Pharmacology · doi:10.1124/mol.53.4.597 · Cited by 162
Trottier, E., Belzil, A., Stoltz, C. M., & Anderson, A. (1995) · Gene · doi:10.1016/0378-1119(94)00916-g · Cited by 160
Ferguson, S., LeCluyse, E. L., Negishi, M., & Goldstein, J. A. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.3.737 · Cited by 160
Schuetz, E. G., Brimer, C., & Schuetz, J. D. (1998) · Molecular Pharmacology · doi:10.1124/mol.54.6.1113 · Cited by 155
A Pharmacophore for Human Pregnane X Receptor Ligands
Ekins, S., & Erickson, J. A. (2002) · Drug Metabolism and Disposition · doi:10.1124/dmd.30.1.96 · Cited by 155
Zelko, I. N., Sueyoshi, T., Kawamoto, T., Moore, R., & Negishi, M. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.8.2838-2846.2001 · Cited by 149
Regulation of Drug Transporter Gene Expression by Nuclear Receptors
Staudinger, J. L., Madan, A., Carol, K. M., & Parkinson, A. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.5.523 · Cited by 147
Characterization of a Phenobarbital-responsive Enhancer Module in Mouse P450 Cyp2b10 Gene
Honkakoski, P., & Negishi, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.23.14943 · Cited by 142
Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays
Gerhold, D. L., Lu, M., Xu, J. Y., Austin, C. P., Caskey, C. T., & Rushmore, T. H. (2001) · Physiological Genomics · doi:10.1152/physiolgenomics.2001.5.4.161 · Cited by 141
Dotzlaw, H., Leygue, E., Watson, P. H., & Murphy, L. C. (1999) · PubMed · Cited by 140
Kamiya, A., Inoue, Y., & Gonzalez, F. J. (2003) · Hepatology · doi:10.1053/jhep.2003.50212 · Cited by 140
Barwick, J. L., Quattrochi, L. C., Mills, A. S., Potenza, C., Tukey, R. H., & Guzelian, P. S. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09115-1 · Cited by 134
Handschin, C., Podvinec, M., & Meyer, U. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.20.10769 · Cited by 133
Self-citationTakeshita, A., Taguchi, M., Koibuchi, N., & Ozawa, Y. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111245200 · Cited by 131
Dunkov, B. C., Guzov, V. M., Mocelin, G., Shotkoski, F. A., Brun‐Barale, A., Amichot, M., ffrench‐Constant, R. H., & Feyereisen, R. (1997) · DNA and Cell Biology · doi:10.1089/dna.1997.16.1345 · Cited by 127
Guo, G. L., Staudinger, J. L., Ogura, K., & Klaassen, C. D. (2002) · Molecular Pharmacology · doi:10.1124/mol.61.4.832 · Cited by 127
Falkner, K. C., Pinaire, J. A., Xiao, G., Geoghegan, T. E., & Prough, R. A. (2001) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12625-9 · Cited by 126
Alternatively spliced isoforms of the human constitutive androstane receptor
Auerbach, S. S. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg419 · Cited by 124
Phenobarbital-Elicited Activation of Nuclear Receptor CAR in Induction of Cytochrome P450 Genes
Zelko, I. N., & Negishi, M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3557 · Cited by 120
Functional and structural comparison of PXR and CAR
Moore, J. T., Moore, L. B., Maglich, J. M., & Kliewer, S. A. (2003) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00481-6 · Cited by 119
PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides
Coumoul, X., Diry, M., & Barouki, R. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01298-4 · Cited by 118
Mechanisms of Hepatic Transport of Drugs: Implications for Cholestatic Drug Reactions
Bohan, A., & Boyer, J. L. (2002) · Seminars in Liver Disease · doi:10.1055/s-2002-30099 · Cited by 117
Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance
Dussault, I., Yoo, H., Lin, M., Wang, E., Fan, M. Q., BATTA, A. K., Salen, G., Erickson, S. K., & FORMAN, B. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0336235100 · Cited by 117
Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors
Akiyama, T. E., & Gonzalez, F. J. (2003) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00480-4 · Cited by 117
Ourlin, J.-C., Lasserre, F., Pineau, T., Fabre, J. M., Cunha, A. S., Maurel, P., Vilarem, M., & Pascussi, J. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0383 · Cited by 114
Characterization of Phenobarbital-inducible Mouse Cyp2b10 Gene Transcription in Primary Hepatocytes
Honkakoski, P., Moore, R., Gynther, J., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.16.9746 · Cited by 113
Hepatic Cytochrome P450 Regulation in Disease States
Cheng, P., & Morgan, E. T. (2001) · Current Drug Metabolism · doi:10.2174/1389200013338676 · Cited by 113
Dussault, I., Lin, M., Hollister, K., Fan, M. Q., Termini, J. S., Sherman, M. A., & FORMAN, B. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5270-5280.2002 · Cited by 112
Willson, T. M., Jones, S. A., Moore, J. T., & Kliewer, S. A. (2001) · Medicinal Research Reviews · doi:10.1002/med.1023 · Cited by 110
Orphan Receptor Promiscuity in the Induction of Cytochromes P450 by Xenobiotics
Smirlis, D., Muangmoonchai, R., Edwards, M., Phillips, I. R., & Shephard, E. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005930200 · Cited by 108
Savas, Ü., Griffin, K. J., & Johnson, E. F. (1999) · Molecular Pharmacology · doi:10.1124/mol.56.5.851 · Cited by 106
Drocourt, L., Pascussi, J., Assénat, E., Fabre, J.-M., Maurel, P., & Vilarem, M. (2001) · PubMed · Cited by 104
Park, Y., Li, H., & KEMPER, B. W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.39.23725 · Cited by 104
Shiraki, T., Sakai, N., Kanaya, E. N., & Jingami, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212859200 · Cited by 102
Schmiedlin‐Ren, P., Thummel, K. E., Fisher, J. M., Paine, M. F., & Watkins, P. B. (2001) · PubMed · Cited by 102
Schuetz, E. G., Schmid, W., Schütz, G., Brimer, C., Yasuda, K., Kamataki, T., Bornheim, L. M., Myles, K. M., & Cole, T. J. (2000) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(24)15361-5 · Cited by 101
Owsley, E., & Chiang, J. Y. L. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00551-5 · Cited by 100
Honkakoski, P., & Negishi, M. (1998) · Biochemical Journal · doi:10.1042/bj3300889 · Cited by 99
Muangmoonchai, R., Smirlis, D., Wong, S. C., Edwards, M., Phillips, I. R., & Shephard, E. A. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3550071 · Cited by 94
Xiong, H., Yoshinari, K., Brouwer, K. L. R., & Negishi, M. (2002) · Drug Metabolism and Disposition · doi:10.1124/dmd.30.8.918 · Cited by 94
Ekins, S., Mirny, L. A., & Schuetz, E. G. (2002) · Pharmaceutical Research · doi:10.1023/a:1021429105173 · Cited by 92
SUZUKI, H., & Sugiyama, Y. (2000) · Seminars in Liver Disease · doi:10.1055/s-2000-8408 · Cited by 92
Organ Clearance Concepts: New Perspectives on Old Principles
Sirianni, G. L., & Pang, K. S. (1997) · Journal of Pharmacokinetics and Biopharmaceutics · doi:10.1023/a:1025792925854 · Cited by 89
Min, G., Kim, H., Bae, Y., Petz, L. N., & Kemper, J. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205239200 · Cited by 89
Stoltz, C. M., Vachon, M.-H., Trottier, E., Dubois, S., Paquet, Y., & Anderson, A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.14.8528 · Cited by 87
Yoshinari, K., Sueyoshi, T., Moore, R., & Negishi, M. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.2.278 · Cited by 84
Min, G., Kemper, J. K., & KEMPER, B. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200051200 · Cited by 83
Modulation of Mouse and Human Phenobarbital-Responsive Enhancer Module by Nuclear Receptors
Mäkinen, J., Frank, C., Jyrkkärinne, J., et al. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.2.366 · Cited by 83
Wang, H., Faucette, S. R., Gilbert, D., Jolley, S. L., Sueyoshi, T., Negishi, M., & LeCluyse, E. L. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.5.620 · Cited by 83
Sonoda, J., Rosenfeld, J. M., Xu, L., Evans, R. M., & Xie, W. (2003) · Current Drug Metabolism · doi:10.2174/1389200033336739 · Cited by 81
Quattrochi, L. C., Mills, A. S., Barwick, J. L., Yockey, C. B., & Guzelian, P. S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.48.28917 · Cited by 79
Huss, J. M., Wang, S. I., Åström, A., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4666 · Cited by 78
TRANSCRIPTIONAL ACTIVATION OF CYTOCHROME P450 GENES BY DIFFERENT CLASSES OF CHEMICAL INDUCERS
Dogra, S. C., Whitelaw, M. L., & May, B. K. (1998) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1998.tb02135.x · Cited by 78
Blumberg, B., Kang, H., Bolado, J., Chen, H., Craig, A. G., Moreno, T. A., Umesono, K., Perlmann, T., Robertis, E. M. D., & Evans, R. M. (1998) · Genes & Development · doi:10.1101/gad.12.9.1269 · Cited by 73
Sidhu, J. S., & Omiecinski, C. J. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36871-5 · Cited by 73
Role reversal: new insights from new ligands for the xenobiotic receptor CAR
Tzameli, I., & Moore, D. D. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00332-5 · Cited by 72
The role of hepatocyte RXRα in xenobiotic-sensing nuclear receptor-mediated pathways
Cai, Y., Konishi, T., Han, G., et al. (2002) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(01)00211-1 · Cited by 70
Jacobs, M. N., Dickins, M., & Lewis, D. F. V. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00021-9 · Cited by 69
Yamamoto, Y., Kawamoto, T., & Negishi, M. (2002) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00456-3 · Cited by 68
Phenobarbital induction of drug/steroid-metabolizing enzymes and nuclear receptor CAR
Kakizaki, S., Yamamoto, Y., Ueda, A., et al. (2003) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00482-8 · Cited by 66
Identification of the novel splicing variants for the hPXR in human livers
Fukuen, S., Fukuda, T., Matsuda, H., Sumida, A., Yamamoto, I., Inaba, T., & Azuma, J. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02469-5 · Cited by 65
Sakuma, T., Ohtake, M., Katsurayama, Y., Jarukamjorn, K., & Nemoto, N. (1999) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(24)14914-8 · Cited by 64
Columbano, A., Pibiri, M., Concas, D., Molotzu, F., Simbula, G., Cossu, C., & Columbano, A. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg063 · Cited by 62
Li, W., Petersen, R. A., Schuler, M. A., et al. (2002) · Insect Molecular Biology · doi:10.1046/j.1365-2583.2002.00363.x · Cited by 61
Fraser, D. J., Podvinec, M., Kaufmann, M., & Meyer, U. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204699200 · Cited by 60
Self-citationInduction of CYP3A Expression by Dehydroepiandrosterone: Involvement of the Pregnane X Receptor
Ripp, S. L., Fitzpatrick, J. L., Peters, J. M., & Prough, R. A. (2002) · Drug Metabolism and Disposition · doi:10.1124/dmd.30.5.570 · Cited by 60
Physiological and pathophysiological regulation of cytochrome P450.
Morgan, E. T., Sewer, M. B., Iber, H., Gonzalez, F. J., Lee, Y.-H., Tukey, R. H., Okino, S. T., Vu, T. P., Chen, Y. H., Sidhu, J. S., et al. (1998) · PubMed · Cited by 60
Handschin, C., Podvinec, M., Amherd, R., Looser, R., Ourlin, J.-C., & Meyer, U. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202739200 · Cited by 59
Self-citationROLE OF GLUCOCORTICOID RECEPTOR AND CONSTITUTIVE ANDROSTANE RECEPTOR
Gerbal‐Chaloin, S., Daujat‐Chavanieu, M., Pascussi, J., Pichard‐Garcia, L., Vilarem, M., & Maurel, P. (2002) · Cited by 59
Toell, A., Kröncke, K., Kleinert, H., & Carlberg, C. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10104 · Cited by 57
I. Nuclear receptors and bile acid homeostasis
Goodwin, B. J., & Kliewer, S. A. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00044.2002 · Cited by 57
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Metadata
- Authors
- Handschin, C., & Meyer, U. A.
- Venue
- Pharmacological Reviews
- Publisher
- Elsevier BV
- Published
- 2003-12
- Volume
- 55
- Issue
- 4
- Pages
- 649-673
- ISSN
- 0031-6997 (ISSN-L)
- OpenAlex
- W2128772465
- Cited by
- 470
- References
- 242
- FWCI
- 24.05
- Type
- journal article
- Language
- en
- Open access
- closed
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