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Cited by 278

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Lipofuscin and Aging: A Matter of Toxic Waste

Open access
Gray, Douglas A., Woulfe, John·2005·Science of Aging Knowledge Environment
DOI 10.1126/sageke.2005.5.re1
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Abstract

Lipofuscin is membrane-bound cellular waste that can be neither degraded nor ejected from the cell but can only be diluted through cell division and subsequent growth. The fate of postmitotic cells is to accumulate lipofuscin, which as an "aging pigment" has been considered a reliable biomarker for the age of cells such as neurons and, by extension, their hosts. In the aging human brain, deposits of lipofuscin are not uniformly distributed but are concentrated in specific regions of functional interest. The prevailing thought is that the major source of lipofuscin is incomplete lysosomal degradation of damaged mitochondria. Accumulating evidence suggests that lipofuscin is not benign but can impair the functioning of seemingly unrelated cellular systems, including the ubiquitin/proteasome pathway. A damaging feedback loop of lysosomal and proteasomal inhibition may occur as lipofuscin accumulates, leading to what has been appropriately named a "garbage catastrophe." Reversing this catastrophe presents a formidable challenge.

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Metadata

Authors
Gray, D. A., & Woulfe, J.
Venue
Science of Aging Knowledge Environment
Publisher
American Association for the Advancement of Science (AAAS)
Published
2005-02-02
Volume
2005
Issue
5
Pages
re1-re1
ISSN
1539-6150 (ISSN-L)
DOI
10.1126/sageke.2005.5.re1
OpenAlex
W2024215142
Cited by
278
References
2
FWCI
5.24
Type
journal article
Language
en
Open access
green

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