Why do we age?

The p66shc adaptor protein controls oxidative stress response and life span in mammals

Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature · doi:10.1038/46311 · Cited by 1,712 · see citing works

Cellular senescence: when bad things happen to good cells

Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441 · see citing works

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · see citing works

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239 · see citing works

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,359 · see citing works

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., & Kenyon, C. (2003) · Nature · doi:10.1038/nature01789 · Cited by 2,280 · see citing works

Understanding the odd science of aging

Kirkwood, T. B. L. (2005) · Cell · doi:10.1016/j.cell.2005.01.027 · Cited by 1,984 · see citing works

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

Tchkonia, T., Zhu, Y., van Deursen, J., Campisi, J., & Kirkland, J. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64098 · Cited by 1,774 · see citing works

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

Kumari, R., & Jat, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.645593 · Cited by 1,622 · see citing works

Adverse Childhood Experiences and Adult Risk Factors for Age-Related Disease: Depression, Inflammation, and Clustering of Metabolic Risk Markers

Danese, A., Moffitt, T. E., Harrington, H., Milne, B. J., Polanczyk, G., Pariante, C. M., Poulton, R., & Caspi, A. (2009) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpediatrics.2009.214 · Cited by 1,165 · see citing works

Senescence-messaging secretome: SMS-ing cellular stress

Kuilman, T., & Peeper, D. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2560 · Cited by 909 · see citing works

Accumulation of senescent cells in Mitotic tissue of aging primates

Jeyapalan, J. C., Ferreira, M., Sedivy, J. M., & Herbig, U. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.008 · Cited by 571 · see citing works

Mitochondrial DNA mutations in human colonic crypt stem cells

Taylor, R. W., Barron, M. J., Borthwick, G. M., Gospel, A., Chinnery, P. F., Samuels, D. C., Taylor, G. A., Plusa, S. M., Needham, S. J., Greaves, L. C., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19435 · Cited by 530 · see citing works

Cancer and ageing: rival demons?

Campisi, J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1073 · Cited by 512 · see citing works

Hallmarks of senescence in carcinogenesis and cancer therapy

Shay, J. W., & Roninson, I. B. (2004) · Oncogene · doi:10.1038/sj.onc.1207518 · Cited by 502 · see citing works

MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8

Bhaumik, D., Scott, G. K., Schokrpur, S., Patil, C. K., Orjalo, A. V., Rodier, F., Lithgow, G. J., & Campisi, J. (2009) · Aging · doi:10.18632/aging.100042 · Cited by 500 · see citing works

The Genetics of Aging

Finch, C. E., & Ruvkun, G. (2001) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.2.1.435 · Cited by 446 · see citing works

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis

Trinei, M., Giorgio, M., Cicalese, A., Barozzi, S., Ventura, A., Migliaccio, E., Milia, E., Padura, I. M., Raker, V. A., Maccarana, M., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205513 · Cited by 436 · see citing works

Cellular senescence: a link between cancer and age-related degenerative disease?

Campisi, J., Andersen, J. K., Kapahi, P., & Melov, S. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.09.001 · Cited by 421 · see citing works

Caloric restriction, SIRT1 and longevity

Cantó, C., & Auwerx, J. (2009) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.03.008 · Cited by 395 · see citing works

Cellular senescence, cancer and aging: the telomere connection

Campisi, J., Kim, S.-H., Lim, C.-S., & Rubio, M. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00160-7 · Cited by 400 · see citing works

Oncogene-Induced Cell Senescence — Halting on the Road to Cancer

Mooi, W. J., & Peeper, D. S. (2006) · New England Journal of Medicine · doi:10.1056/nejmra062285 · Cited by 371 · see citing works

Redox control of senescence and age-related disease.

Chandrasekaran, A., Idelchik, M. D. P. S., & Melendez, J. A. (2017) · Redox Biology · doi:10.1016/j.redox.2016.11.005 · Cited by 360 · see citing works

The telomerase activator TA‐65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence

de Jesus, B. B., Schneeberger, K., Vera, E., Tejera, A., Harley, C. B., & Blasco, M. A. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00700.x · Cited by 348 · see citing works

A Transcriptional Profile of Aging in the Human Kidney

Rodwell, G. E. J., Sonu, R., Zahn, J. M., Lund, J., Wilhelmy, J., Wang, L., Xiao, W., Mindrinos, M., Crane, E., Segal, E., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020427 · Cited by 338 · see citing works

An evolutionary perspective on the mechanisms of immunosenescence

Shanley, D. P., Aw, D., Manley, N. R., & Palmer, D. B. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.05.001 · Cited by 315 · see citing works

Revenge of the “Sit”: How lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity

Vaynman, S., & Gomez‐Pinilla, F. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20979 · Cited by 299 · see citing works

The emergence of humans: the coevolution of intelligence and longevity with intergenerational transfers

Kaplan, H. S., & Robson, A. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152502899 · Cited by 288 · see citing works

Extracellular superoxide dismutase is a major antioxidant in human fibroblasts and slows telomere shortening

Serra, V., von Zglinicki, T., Lorenz, M., & Saretzki, G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207939200 · Cited by 278 · see citing works

How should we grade frailty in nursing home patients?

Rockwood, K., Abeysundera, M. J., & Mitnitski, A. (2007) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2007.07.012 · Cited by 249 · see citing works

An accelerated assay for the identification of lifespan-extending interventions in <i>Drosophila</i> melanogaster

Bauer, J. H., Goupil, S., Garber, G. B., & Helfand, S. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403493101 · Cited by 234 · see citing works

Biology of premature ageing in survivors of cancer

Cupit-Link, M. C., Kirkland, J. L., Ness, K. K., Armstrong, G. T., Tchkonia, T., LeBrasseur, N. K., Armenian, S. H., Ruddy, K. J., & Hashmi, S. K. (2017) · ESMO Open · doi:10.1136/esmoopen-2017-000250 · Cited by 214 · see citing works

Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes

Campisi, J. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00152-3 · Cited by 218 · see citing works

Optimal annual routines: behaviour in the context of physiology and ecology

McNamara, J. M., & Houston, A. I. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2007.2141 · Cited by 216 · see citing works

Histone methylation makes its mark on longevity

Han, S., & Brunet, A. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.11.001 · Cited by 204 · see citing works

Selenium Supplementation Restores the Antioxidative Capacity and Prevents Cell Damage in Bone Marrow Stromal Cells In Vitro

Ebert, R., Ulmer, M., Zeck, S., Meissner‐Weigl, J., Schneider, D., Stopper, H., Schupp, N., Kassem, M., & Jakob, F. (2006) · STEM CELLS · doi:10.1634/stemcells.2005-0117 · Cited by 200 · see citing works

Cancer and ageing: convergent and divergent mechanisms

Serrano, M., & Blasco, M. A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2242 · Cited by 182 · see citing works

Internalizing disorders and leukocyte telomere erosion: a prospective study of depression, generalized anxiety disorder and post-traumatic stress disorder

Shalev, I., Moffitt, T. E., Braithwaite, A. W., Danese, A., Fleming, N. I., Goldman-Mellor, S., Harrington, H. L., Houts, R. M., Israel, S., Poulton, R., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.183 · Cited by 155 · see citing works

What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?

Kirkwood, T. B. L., Feder, M., Finch, C. E., Franceschi, C., Globerson, A., Klingenberg, C. P., LaMarco, K., Omholt, S., & Westendorp, R. G. J. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.09.008 · Cited by 144 · see citing works

Accelerated Telomere Attrition Is Associated with Relative Household Income, Diet and Inflammation in the pSoBid Cohort

Shiels, P. G., McGlynn, L. M., MacIntyre, A., Johnson, P. C. D., Batty, G. D., Burns, H., Cavanagh, J., Deans, K. A., Ford, I., McConnachie, A., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022521 · Cited by 143 · see citing works

The evolutionary theories of aging revisited - a mini-review

Ljubuncic, P., & Reznick, A. Z. (2009) · Gerontology · doi:10.1159/000200772 · Cited by 133 · see citing works

The Impact of Immune System Aging on Infectious Diseases

Quiros-Roldan, E., Sottini, A., Natali, P. G., & Imberti, L. (2024) · Microorganisms · doi:10.3390/microorganisms12040775 · Cited by 133 · see citing works

Ageing and the regulation of protein synthesis: a balancing act?

Tavernarakis, N. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.02.004 · Cited by 129 · see citing works

Stem cells and aging in the hematopoietic system

Warren, L. A., & Rossi, D. J. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.03.010 · Cited by 128 · see citing works

Drugs that modulate aging: the promising yet difficult path ahead

Kennedy, B. K., & Pennypacker, J. K. (2014) · Translational research · doi:10.1016/j.trsl.2013.11.007 · Cited by 127 · see citing works

Sex-specific regulation of aging and apoptosis

Tower, J. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.05.001 · Cited by 125 · see citing works

p53-Dependent ICAM-1 overexpression in senescent human cells identified in atherosclerotic lesions

Gorgoulis, V. G., Pratsinis, H., Zacharatos, P., Demoliou, C., Sigala, F., Asimacopoulos, P. J., Papavassiliou, A. G., & Kletsas, D. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700241 · Cited by 122 · see citing works

The Acquired Immune System

Hedrick, S. M. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.020 · Cited by 122 · see citing works

Genetic Determinants of Human Health Span and Life Span: Progress and New Opportunities

Martin, G. M., Bergman, A., & Barzilai, N. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030125 · Cited by 120 · see citing works

Impact of early personal-history characteristics on the pace of aging: implications for clinical trials of therapies to slow aging and extend healthspan

Belsky, D. W., Caspi, A., Cohen, H. J., Kraus, W. E., Ramrakha, S., Poulton, R., & Moffitt, T. E. (2017) · Aging Cell · doi:10.1111/acel.12591 · Cited by 114 · see citing works

Neuroenhancement of love and marriage: the chemicals between us.

Savulescu, J., & Sandberg, A. (2008) · Neuroethics · doi:10.1007/s12152-007-9002-4 · Cited by 111 · see citing works

The mitotic clock in skeletal muscle regeneration, disease and cell mediated gene therapy

Mouly, V., Aamiri, A., Bigot, A., Cooper, R. N., Di Donna, S., Furling, D., Gidaro, T., Jacquemin, V., Mamchaoui, K., Negroni, E., et al. (2005) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2005.01417.x · Cited by 106 · see citing works

Aerobic glycolysis in the primate brain: Reconsidering the implications for growth and maintenance

Bauernfeind, A. L., Barks, S. K., Duka, T., Grossman, L. I., Hof, P. R., & Sherwood, C. C. (2014) · Brain Structure and Function · doi:10.1007/s00429-013-0662-z · Cited by 105 · see citing works

Evolutionary medicine and chronic inflammatory state—known and new concepts in pathophysiology

Straub, R. H. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0861-8 · Cited by 105 · see citing works

Human embryonic stem cells: Long term stability, absence of senescence and a potential cell source for neural replacement

Zeng, X., & Rao, M. S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.09.017 · Cited by 92 · see citing works

Mutational fingerprints of aging

Dolle, M. E. T. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.2.545 · Cited by 87 · see citing works

Short-term gain, long-term pain: the senescence life cycle and cancer

Chan, A. S. L., & Narita, M. (2019) · Genes &amp; Development · doi:10.1101/gad.320937.118 · Cited by 80 · see citing works

Integrated evolutionary, immunological, and neuroendocrine framework for the pathogenesis of chronic disabling inflammatory diseases

Straub, R. H., & Besedovsky, H. O. (2003) · The FASEB Journal · doi:10.1096/fj.03-0433hyp · Cited by 85 · see citing works

Calcium, Bioenergetics, and Parkinson’s Disease

Zampese, E., & Surmeier, D. J. (2020) · Cells · doi:10.3390/cells9092045 · Cited by 79 · see citing works

Genetic influences on blood lipids and cardiovascular disease risk: tools for primary prevention

Ordovas, J. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27113e · Cited by 74 · see citing works

The impact of base excision DNA repair in age-related neurodegenerative diseases

Leandro, G. S., Sykora, P., & Bohr, V. A. (2015) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2014.12.011 · Cited by 72 · see citing works

Genome Dynamics in Aging Mice

Dollé, M. E. T., & Vijg, J. (2002) · Genome Research · doi:10.1101/gr.125502 · Cited by 66 · see citing works

Evidence that mutation accumulation does not cause aging in <i>Saccharomyces cerevisiae</i>

Kaya, A., Lobanov, A. V., & Gladyshev, V. N. (2015) · Aging Cell · doi:10.1111/acel.12290 · Cited by 60 · see citing works

Which is the most significant cause of aging?

Liochev, S. (2015) · Antioxidants · doi:10.3390/antiox4040793 · Cited by 56 · see citing works

Cytoprotective Polyphenols Against Chronological Skin Aging and Cutaneous Photodamage

Davinelli, S., Bertoglio, J. C., Polimeni, A., & Scapagnini, G. (2018) · Current Pharmaceutical Design · doi:10.2174/1381612823666171109102426 · Cited by 57 · see citing works

Stem cell ageing and non-random chromosome segregation

Charville, G. W., & Rando, T. A. (2011) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2010.0279 · Cited by 45 · see citing works

An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence.

Rovillain, E., Mansfield, L., Lord, C. J., Ashworth, A., & Jat, P. S. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-355 · Cited by 43 · see citing works

Reassessing the role of p53 in cancer and ageing from an evolutionary perspective

Aranda-Anzaldo, A., & Dent, M. A. R. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.01.001 · Cited by 36 · see citing works

Between Scylla and Charybdis: p53 links tumor suppression and aging

Campisi, J. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00006-4 · Cited by 33 · see citing works

Profiling Plasma Peptides for the Identification of Potential Ageing Biomarkers in Chinese Han Adults

Lu, J., Huang, Y., Wang, Y., Li, Y., Zhang, Y., Wu, J., Zhao, F., Meng, S., Yu, X., Ma, Q., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039726 · Cited by 33 · see citing works

Effects of early-stage aging on locomotor dynamics and hindlimb muscle force production in the rat

Horner, A. M., Russ, D. W., & Biknevicius, A. R. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.055087 · Cited by 26 · see citing works

Emerging Concepts for the Pathogenesis of Chronic Disabling Inflammatory Diseases: Neuroendocrine-immune Interactions and Evolutionary Biology

STRAUB, R. H., DEL REY, A., & BESEDOVSKY, H. O. (2007) · Psychoneuroimmunology · doi:10.1016/b978-012088576-3/50014-9 · Cited by 14 · see citing works

Aging of the Immune System Across Different Species

Nikolich-Žugich, J., & Čičin-Šain, L. (2010) · The Comparative Biology of Aging · doi:10.1007/978-90-481-3465-6_15 · Cited by 9 · see citing works