Cited by 118Heat shock proteins researchGenetics, Aging, and Longevity in Model OrganismsAntioxidants, Aging, Portulaca oleracea

Exogenous Hsp70 delays senescence and improves cognitive function in aging mice

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Bobkova, Natalia V., Evgen’ev, Mikhail, Garbuz, David G., Kulikov, Alexei M., Morozov, Alexei, Samokhin, Alexander, Velmeshev, Dmitri, Medvinskaya, Natalia +3 more·2015·Proceedings of the National Academy of Sciences

Abstract

Significance: The compromised ability of neurons to express Heat Shock Protein 70 (Hsp70) correlates with aging-related neurodegeneration. In this study, middle-aged and old mice were treated chronically until death with human Hsp70 delivered intranasally and were investigated after 5 or 9 mo of Hsp70 treatment for their cognitive ability and synaptic density. Hsp70 treatment extended mean and maximum lifespan, improved learning and memory in old animals, increased curiosity, decreased anxiety, and helped maintain synaptic structures that degrade with age. These results provide evidence that intranasal administration of Hsp70 could have significant therapeutic potential in preserving brain tissue and memory for middle-age and old individuals and could be applied either as unique self-contained treatment or in combination with other pharmacological therapies.

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Crossref · 10.1073/pnas.1516131112

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  • There are 4 core genes significantly downregulated in astrocytes in all brain regions, 2 of which are heat shock proteins.

    “There are 4 core genes significantly downregulated in astrocytes in all brain regions, 2 of which are heat shock proteins (Figure 2G), protective molecular chaperones that prevent protein damage (Bobkova et al., 2015).”

    From The aging astrocyte transcriptome from multiple regions of the mouse brain. (2018) · cites this paper as Bobkova et al., 2015

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Authors
Bobkova, N. V., Evgen’ev, M., Garbuz, D. G., Kulikov, A. M., Morozov, A., Samokhin, A., Velmeshev, D., Medvinskaya, N., Nesterova, I., Pollock, A., & Nudler, E.
Affiliations
  • Russian Academy of Sciences (RU)
  • Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow, 142290, Russia;
  • Engelhardt Institute of Molecular Biology (RU)
  • Institute of Developmental Biology, Moscow, 124319, Russia;
  • Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia;
  • Howard Hughes Medical Institute (US)
Corresponding author
Nudler, Evgeny
Venue
Proceedings of the National Academy of Sciences
Published
2015-12-14
Volume
112
Issue
52
Pages
16006-16011
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2270421926
Cited by
118
References
59
Citations by year
2026: 8 · 2025: 17 · 2024: 11 · 2023: 10 · 2022: 8 · 2021: 12 · 2020: 7 · 2019: 17 · 2018: 16 · 2017: 6 · 2016: 6
FWCI
4.05
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Howard Hughes Medical Institute (NA)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Antioxidants, Aging, Portulaca oleracea
Keywords
HSP70, intranasal administration, aging, lifespan extension, cognitive function, learning and memory, neurodegeneration, synaptophysin, lipofuscin accumulation, proteasome activity, synaptic integrity, neuroprotection
MeSH terms
Aging, Animals, Brain, Cognition, Exploratory Behavior, Humans, Lipofuscin, Longevity, Male, Memory, Mice, Inbred Strains, Microscopy, Fluorescence, Motor Activity, Recombinant Proteins, Blotting, Western, Synaptophysin, Maze Learning, HSP70 Heat-Shock Proteins, Protein Subunits, Proteasome Endopeptidase Complex

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