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Cited by 126Genomics and Chromatin DynamicsEpigenetics and DNA MethylationChromatin Remodeling and Cancer

Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin looping

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Loubiere, V., Papadopoulos, G. L., Szabo, Q., Martinez, A-M., Cavalli, G.·2020·Science Advances
DOI 10.1126/sciadv.aax4001PMC PMC6954061
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Abstract

Polycomb repressive complex 1 shapes 3D loops associated with transcription of key developmental genes.

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  • PRC1 mediates chromatin interactions between a subset of active developmental enhancers and promoters in Drosophila.

    “Moreover, PRC1 was recently found to mediate chromatin interactions between a subset of active developmental enhancers and promoters in Drosophila [361].”

    From Transcriptional enhancers and their communication with gene promoters (2021) · cites this paper as [361]

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Sorted by citations

Authors
Loubiere, V., Papadopoulos, G. L., Szabo, Q., Martinez, A.-M., & Cavalli, G.
Affiliations
  • Institute of Human Genetics, UMR 9002, CNRS–University of Montpellier, 34396 Montpellier, France.
  • Centre National de la Recherche Scientifique (FR)
Corresponding author
  • Martinez, A-M.
  • Cavalli, G.
ORCID
Venue
Science Advances
Publisher
American Association for the Advancement of Science (AAAS)
Published
2020-01-10
Volume
6
Issue
2
Pages
eaax4001-eaax4001
ISSN
2375-2548 (ISSN-L)
DOI
10.1126/sciadv.aax4001
PMC
PMC6954061
OpenAlex
W2999808884
Cited by
126
References
4
Citations by year
2026: 13 · 2025: 24 · 2024: 16 · 2023: 24 · 2022: 21 · 2021: 22 · 2020: 6
FWCI
5.97
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Science Advances (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by-nc)
Funders
  • H2020 European Research Council (2017-AdG No 788972)
  • European Research Council (ERC-2008-AdG No 232947)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
PRC1, chromatin looping, developmental gene expression, RING1B, 3D genome organization, neuronal differentiation, transcriptional regulation, chromatin interactions
MeSH terms
Animals, Cell Differentiation, Chromatin, Drosophila melanogaster, Enhancer Elements, Genetic, Promoter Regions, Genetic, Protein Binding, Gene Expression Regulation, Developmental, Response Elements, Genes, Developmental, Mice, Genetic Loci, Neural Stem Cells, Imaginal Discs, Polycomb Repressive Complex 1

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