Impact of mRNA chemistry and manufacturing process on innate immune activation

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Items 101–200 of 353

1. An influenza mRNA vaccine protects ferrets from lethal infection with highly pathogenic avian influenza A(H5N1) virus
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2. Subcutaneous delivery of FGF21 mRNA therapy reverses obesity, insulin resistance, and hepatic steatosis in diet-induced obese mice
   Stefano Bartesaghi, Kristina Wallenius, Daniel Hovdal, Mathias Liljeblad, Simonetta Wallin, Niek Dekker, Louise Barlind, Nigel M. Davies, Frank Seeliger, Maria Sörhede Winzell et al. · 2022 · Molecular Therapy — Nucleic Acids
3. mRNA therapy corrects defective glutathione metabolism and restores ureagenesis in preclinical argininosuccinic aciduria
   Sonam Gurung, Oskar Vilhelmsson Timmermand, Dany P.B. Perocheau, Ana Luisa Gil-Martínez, Magdalena Minnion, Loukia Touramanidou, Sherry Fang, Martina Messina, Youssef Khalil, Justyna Śpiewak et al. · 2024 · Science Translational Medicine
4. RNA-based therapeutics to treat human fungal infections
   Bruch, Alexander, Kelani, Abdulrahman A., Blango, Matthew G. · 2022 · Trends in Microbiology
5. Tumor-activated IL-2 mRNA delivered by lipid nanoparticles for cancer immunotherapy
   Yuhao Jiang, Yanhao Zhang, Chao Liu, Jinyu Liu, Wenliang Xue, Zihao Wang, Xinsong Li · 2024 · Journal of Controlled Release
6. Ushering in the era of tRNA medicines
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7. Development of an extended half-life GM-CSF fusion protein for Parkinson's disease
   Pravin Yeapuri, Katherine E. Olson, Yaman Lu, Mai Mohamed Abdelmoaty, Krista L. Namminga, Milica Marković, Jatin Machhi, Rodney Lee Mosley, Howard Eliot Gendelman · 2022 · Journal of Controlled Release
8. Seasonal quadrivalent mRNA vaccine prevents and mitigates influenza infection
   Christina M. Kackos, Jennifer DeBeauchamp, Christopher J.H. Davitt, Jan Lonzarić, Robert E. Sealy, Julia L. Hurwitz, Marcelo M. Samsa, Richard J. Webby · 2023 · npj Vaccines
9. Advances in mRNA LNP-Based Cancer Vaccines: Mechanisms, Formulation Aspects, Challenges, and Future Directions
   Eslam Ramadan, Ali Ahmed Ali Ismeal, Youssef Wahib Naguib · 2024 · Journal of Personalized Medicine
10. Aging through an epitranscriptomic lens
    Mary E. McMahon, Craig M. Forester, Rochelle Buffenstein · 2021 · Nature Aging
11. Complete Chemical Synthesis of Minimal Messenger RNA by Efficient Chemical Capping Reaction
    Naoko Abe, Akihiro Imaeda, Masahito Inagaki, Zhenmin Li, Daisuke Kawaguchi, Kaoru Onda, Yuko Nakashima, Satoshi Uchida, Fumitaka Hashiya, Yasuaki Kimura et al. · 2022 · ACS Chemical Biology
12. A Lassa virus mRNA vaccine confers protection but does not require neutralizing antibody in a guinea pig model of infection
    Adam J. Ronk, Nicole M. Lloyd, Min Zhang, Caroline G. Atyeo, Hailee R. Perrett, Chad E. Mire, Kathryn M. Hastie, Rogier W. Sanders, Philip J. M. Brouwer, Erica Ollmann Saphire et al. · 2023 · Nature Communications
13. Boosting with Omicron-matched or historical mRNA vaccines increases neutralizing antibody responses and protection against B.1.1.529 infection in mice
    Baoling Ying, Suzanne M. Scheaffer, Bradley M. Whitener, Chieh-Yu Liang, Oleksandr Dmytrenko, Samantha Mackin, Kai Wu, Diana Wing Lee, Laura E. Avena, Zhenlu Chong et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
14. Cancer cells restrict immunogenicity of retrotransposon expression via distinct mechanisms
    Siyu Sun, Eunae You, Jungeui Hong, David Hoyos, Isabella S. Del Priore, Kaloyan M. Tsanov, Om Mattagajasingh, Andrea Di Gioacchino, Sajid A. Marhon, Jonathan A. Chacon-Barahona et al. · 2024 · Immunity
15. mRNA and Adenoviral Vector Vaccine Platforms Utilized in COVID-19 Vaccines: Technologies, Ecosystem, and Future Directions
    Ryo Okuyama · 2023 · Vaccines
16. Effect of in vitro transcription conditions on yield of high quality messenger and self-amplifying RNA
    Petya G. Popova, Melissa A. Lagace, George Tang, Anna K. Blakney · 2024 · European Journal of Pharmaceutics and Biopharmaceutics
17. Nucleobase-modified nucleosides and nucleotides: Applications in biochemistry, synthetic biology, and drug discovery
    Anthony J. Berdis · 2022 · Frontiers in Chemistry
18. mRNA COVID-19 Vaccines—Facts and Hypotheses on Fragmentation and Encapsulation
    Jacques Demongeot A, Cécile Fougère · 2022 · Vaccines
19. Expanding the Reach of Monoclonal Antibodies: A Review of Synthetic Nucleic Acid Delivery in Immunotherapy
    Christopher W. Chung, Sagar B. Kudchodkar, Curtis N. Chung, Young K. Park, Ziyang Xu, Norbert Pardi, Mohamed Abdel‐Mohsen, Kar Muthumani · 2023 · Antibodies
20. Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death
    Chang, Shih Chieh, Gopal, Pooja, Lim, Shuhui, Wei, Xiaona, Chandramohan, Arun, Mangadu, Ruban, Smith, Jeffrey, Ng, Simon, Gindy, Marian, Phan, Uyen et al. · 2022 · Cell Chemical Biology
21. RNA therapeutics for cardiovascular disease
    Christian Boada, Roman A. Sukhovershin, Roderic Ivan Pettigrew, John P. Cooke · 2021 · Current Opinion in Cardiology
22. Quality by design approach to improve quality and decrease cost of in vitro transcription of mRNA using design of experiments
    Jimmy Boman, Tjaša Marušič, Tina Vodopivec Seravalli, Janja Skok, Fredrik H. Pettersson, Kristina Šprinzar Nemec, Henrik Widmark, Rok Sekirnik · 2024 · Biotechnology and Bioengineering
23. Leveraging mRNA technology for antigen based immuno-oncology therapies
    Charalampos S. Floudas, Siranush Sarkizova, Michele Ceccarelli, Wei Zheng · 2025 · Journal for ImmunoTherapy of Cancer
24. Nucleic acid delivery and nanoparticle design for COVID vaccines
    Jason L. Andresen, Owen S. Fenton · 2021 · MRS Bulletin
25. Recent Progress in Nucleic Acid Pulmonary Delivery toward Overcoming Physiological Barriers and Improving Transfection Efficiency
    Qiyue Wang, Chaozhi Bu, Qihao Dai, Jinhua Chen, Ruitao Zhang, Xiaomin Zheng, Hao Ren, Xiaofei Xin, Xueming Li · 2024 · Advanced Science
26. COVID-19, Influenza and RSV: Surveillance-informed prevention and treatment – Meeting report from an isirv-WHO virtual conference
    Jennifer L. McKimm‐Breschkin, Alan J Hay, Bin Cao, Rebecca Jane Cox, Jake W Dunning, Ann C. Moen, Daniel Olson, Andrés Pizzorno, Frederick G. Hayden · 2021 · Antiviral Research
27. Intermittent lipid nanoparticle mRNA administration prevents cortical dysmyelination associated with arginase deficiency
    Suhail Khoja, Xiao-Bo Liu, Brian Truong, Matthew Nitzahn, Jenna Lambert, Adam Eliav, Eram Nasser, Emma Randolph, Kristine E. Burke, Rebecca A. White et al. · 2022 · Molecular Therapy — Nucleic Acids
28. Advances in mRNA vaccines
    Mengyun Li, Zining Wang, Chunyuan Xie, Xiaojun Xia · 2022 · International review of cytology
29. mRNA vaccine in gastrointestinal tumors: Immunomodulatory effects and immunotherapy
    Ao Zhang, Qingming Ji, Xia Sheng, Hui Wu · 2023 · Biomedicine & Pharmacotherapy
30. Functions and therapeutic applications of pseudouridylation
    Nan Luo, Qiang Huang, Mei‐Ling Zhang, Chengqi Yi · 2025 · Nature Reviews Molecular Cell Biology
31. Circular RNAs in and out of Cells: Therapeutic Usages of Circular RNAs
    Mingyu Ju, Dayeon Kim, Geurim Son, Jinju Han · 2023 · Molecules and Cells
32. Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant
    Suzanne M. Scheaffer, Diana Wing Lee, Bradley M. Whitener, Baoling Ying, Kai Wu, Hardik Jani, Philippa Martin, Nicholas J. Amato, Laura E. Avena, Daniela Montes Berrueta et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
33. mRNA-delivery of IDO1 suppresses T cell-mediated autoimmunity
    Laurie Lea Kenney, Rebecca Suet-Yan Chiu, Michelle N Dutra, Alexandra Wactor, Chris Honan, Lukas M. Shelerud, Joshua J. Corrigan, Kelly J. Yu, Joseph D. Ferrari, Kate L. Jeffrey et al. · 2024 · Cell Reports Medicine
34. Universal Flu mRNA Vaccine: Promises, Prospects, and Problems
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35. CMC Strategies and Advanced Technologies for Vaccine Development to Boost Acceleration and Pandemic Preparedness
    Maria Monica Castellanos, Hervé Gressard, Xiangming Li, Claudia Magagnoli, Alessio Moriconi, Daniela Stranges, Laurent Strodiot, Mónica Soto, Magdalena Zwierzyna, Cristiana Campa · 2023 · Vaccines
36. An mRNA-based platform for the delivery of pathogen-specific IgA into mucosal secretions
    Cailin E. Deal, Angelene F. Richards, Tracy Yeung, Max J. Maron, Ziqiu Wang, Yen‐Ting Lai, Brian R. Fritz, Sunny Himansu, Elisabeth Narayanan, Ding Liu et al. · 2023 · Cell Reports Medicine
37. Improved therapeutic efficacy in two mouse models of methylmalonic acidemia (MMA) using a second-generation mRNA therapy.
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38. RNA in Cancer Immunotherapy: Unlocking the Potential of the Immune System
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39. Advances in modification and delivery of nucleic acid drugs
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40. Advancing Cancer Immunotherapy: The Potential of mRNA Vaccines As a Promising Therapeutic Approach
    Falak Goyal, Anandini Chattopadhyay, Umashanker Navik, Aklank Jain, P. Hemachandra Reddy, Gurjit Kaur Bhatti, Jasvinder Singh Bhatti · 2023 · Advanced Therapeutics
41. Efficient circularization of protein-encoding RNAs via a novel cis -splicing system
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42. An inoculation site-retained mRNA vaccine induces robust immune responses against SARS-CoV-2 variants
    Lei Huang, Fanfan Zhao, Muye He, Yi Fang, Xiaoping Ma, Shuaiyao Lu, Entao Li, Hui Qing Xiao, Hanfei Zhu, Xueli Wang et al. · 2024 · Journal of Controlled Release
43. Lateral flow immunoassay for rapid and sensitive detection of dsRNA contaminants in in vitro-transcribed mRNA products
    Dengwang Luo, Zhanfeng Wu, Daming Wang, Jieli Zhang, Fei Shao, Shuo Wang, Stefano Cestellos-Blanco, Dawei Xu, Yuhong Cao · 2023 · Molecular Therapy — Nucleic Acids
44. Sending a Message: Use of mRNA Vaccines to Target the Tumor Immune Microenvironment
    Fabiola Ramirez, Angelica Zambrano, Robert Hennis, Nathan A. Holland, Rajkumar Lakshmanaswamy, Jessica Ann Chacon · 2023 · Vaccines
45. Exploring the Impact of In Vitro-Transcribed mRNA Impurities on Cellular Responses
    Julien Camperi, Brian Roper, Emily C. Freund, Rebecca A. Leylek, Ariane Nissenbaum, Carolina Galan, Roger H. Caothien, Zhilan Hu, Peggy Ko, Allison Lee et al. · 2024 · Analytical Chemistry
46. The Progress and Evolving Trends in Nucleic-Acid-Based Therapies
    Yunlong Liu, Chunmiao Wang, Xiuping Fu, Mengtian Ren · 2025 · Biomolecules
47. Cancer mRNA vaccines: clinical application progress and challenges
    Hang Li, Lang Min, Haotian Du, Xiawei Wei, Aiping Tong · 2025 · Cancer Letters
48. The mRNA component of LNP-mRNA vaccines triggers IFNAR-dependent immune activation which attenuates the adaptive immune response
    Liat Bar‐On, Hila Cohen, Uri Elia, Lilach Cherry, Ofer Cohen, Noam Erez A · 2025 · Frontiers in Immunology
49. Comprehensive studies on building a scalable downstream process for mRNAs to enable mRNA therapeutics
    Tingting Cui, Kareem Fakhfakh, Hannah N. Turney, Gülin Güler-Gane, Aleksandra D. Toloczko, Martyn E. Hulley, Richard Turner · 2022 · Biotechnology Progress
50. Systemic Exposure, Metabolism, and Elimination of [14C]-Labeled Amino Lipid, Lipid 5, after a Single Administration of mRNA Encapsulating Lipid Nanoparticles to Sprague-Dawley Rats
    Douglas S. Burdette, Lei Ci, Barclay Shilliday, Richard Slauter, Andrew David Auerbach, Matthew Kenney, Örn Almarsson, Eugene Cheung, Tracy Hendrick · 2023 · Drug Metabolism and Disposition
51. Safe and effective aerosolization of in vitro transcribed mRNA to the respiratory tract epithelium of horses without a transfection agent
    Legere, Rebecca M., Cohen, Noah D., Poveda, Cristina, Bray, Jocelyne M., Barhoumi, Rola, Szule, Joseph A., de la Concha-Bermejillo, Andrés, Bordin, Angela I., Pollet, Jeroen · 2021 · Scientific Reports
52. Bacteriophage RNA polymerases: catalysts for mRNA vaccines and therapeutics
    Adithya Nair, Zoltán Kis · 2024 · Frontiers in Molecular Biosciences
53. Mitigating Cellular Dysfunction Through Contaminant Reduction in Synthetic circRNA for High‐Efficiency mRNA‐Based Cell Reprogramming
    Z.D. Zhang, Weiyu Li, Xiangyu Ren, Dengwang Luo, Xiushuang Yuan, Li Zhi Yu, Daming Wang, Yuhong Cao · 2025 · Advanced Science
54. Virus‐Mimic mRNA Vaccine for Cancer Treatment
    Chaoyang Meng, Zhe Chen, Junhua Mai, Qing Shi, Shaohui Tian, Louis Edward Hinkle, Jun Li, Zhe Zhang, Maricela Ramirez, Licheng Zhang et al. · 2021 · Advanced Therapeutics
55. mRNA-based therapies: Preclinical and clinical applications
    Musga Qureischi, Julia Mohr, Estibaliz Arellano-Viera, Sarah E. Knudsen, Farrukh Vohidov, Andoni Garitano-Trojaola · 2022 · International review of cytology
56. Increased neutralization potency and breadth elicited by a SARS-CoV-2 mRNA vaccine forming virus-like particles
    Peng Zhang, Samantha Falcone, Yaroslav Tsybovsky, Mamta Singh, Vinay Gopan, Huiyi Miao, Yuna Seo, Denise Rogers, Isabella Renzi, Yen‐Ting Lai et al. · 2023 · Proceedings of the National Academy of Sciences
57. RNA nanomedicine in liver diseases
    Anita K. Bakrania, Yulin Mo, Gang Zheng, Mamatha Bhat · 2023 · Hepatology
58. Multivalent mRNA-DTP vaccines are immunogenic and provide protection from Bordetella pertussis challenge in mice
    M. Allison Wolf, Joanne M. O’Hara, Graham J. Bitzer, Elisabeth Narayanan, Dylan T. Boehm, Justin R. Bevere, Megan A. DeJong, Jesse M. Hall, Ting Y. Wong, Samantha Falcone et al. · 2024 · npj Vaccines
59. Optimal Chimeric Antigen Receptor (CAR)-mRNA for Transient CAR T Cell Generation
    Reni Kitte, Robert Serfling, Ulrich Blache, Claudius Seitz, Selina Schrader, Ulrike Koehl, Stephan Fricke, Christian Bär, Sandy Tretbar · 2025 · International Journal of Molecular Sciences
60. Novel mRNA vaccines induce potent immunogenicity and afford protection against tuberculosis
    Christopher J. De Voss, Marcellus, Shuailin Li, Alberta Ateere, Helen McShane, Elena Stylianou · 2025 · Frontiers in Immunology
61. Reverse-phase chromatography removes double-stranded RNA, fragments, and residual template to decrease immunogenicity and increase cell potency of mRNA and saRNA
    Andreja Krušič, Nina Mencin, Marta Leban, Evelin Nett, Mario Perković, U. Şahin, Polona Megušar, A. Štrancar, R. Sekirnik · 2025 · Molecular Therapy: Nucleic Acids
62. Physical and chemical advances of synthetic delivery vehicles to enhance mRNA vaccine efficacy
    Hyun Jin Kim, Su Kyoung Seo, Ha Yeon Park · 2022 · Journal of Controlled Release
63. Supercoiled DNA percentage: A key in-process control of linear DNA template for mRNA drug substance manufacturing
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64. DNA-terminus-dependent transcription by T7 RNA polymerase and its C-helix mutants
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65. Removing immunogenic double-stranded RNA impurities post in vitro transcription synthesis for mRNA therapeutics production: A review of chromatography strategies
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66. Removal of dsRNA byproducts using affinity chromatography
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67. Nucleoside modifications of in vitro transcribed mRNA to reduce immunogenicity and improve translation of prophylactic and therapeutic antigens
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68. mRNA vaccines encoding computationally optimized hemagglutinin elicit protective antibodies against future antigenically drifted H1N1 and H3N2 influenza viruses isolated between 2018-2020
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69. A new approach to RNA synthesis: immobilization of stably and functionally co-tethered promoter DNA and T7 RNA polymerase
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70. N1-methylpseudouridine-incorporated mRNA enhances exogenous protein expression and suppresses immunogenicity in primary human fibroblast-like synoviocytes
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71. Altering the mRNA-1273 dosing interval impacts the kinetics, quality, and magnitude of immune responses in mice
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72. Lipid nanoparticle-encapsulated mRNA therapy corrects serum total bilirubin level in Crigler-Najjar syndrome mouse model
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73. Terminal hairpins improve protein expression in IRES-initiated mRNA in the absence of a cap and polyadenylated tail
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74. Mesoporous Silica Particle as an RNA Adsorbent for Facile Purification of In Vitro-Transcribed RNA
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75. Hepatocyte Nuclear Factor 4 alpha 2 Messenger RNA Reprograms Liver‐Enriched Transcription Factors and Functional Proteins in End‐Stage Cirrhotic Human Hepatocytes
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76. mRNA-1273 and Ad26.COV2.S vaccines protect against the B.1.621 variant of SARS-CoV-2
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77. DNA fragments detected in monovalent and bivalent Pfizer/BioNTech and Moderna modRNA COVID-19 vaccines from Ontario, Canada: Exploratory dose response relationship with serious adverse events.
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78. Quantification of residual plasmid DNA and SV40 promoter-enhancer sequences in Pfizer/BioNTech and Moderna modRNA COVID-19 vaccines from Ontario, Canada
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79. Synthetic mRNA rescues very long-chain acyl-CoA dehydrogenase deficiency in patient fibroblasts and a murine model
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80. Natural Wood‐Derived Macroporous Cellulose for Highly Efficient and Ultrafast Elimination of Double‐Stranded RNA from In Vitro‐Transcribed mRNA
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81. mRNA biotherapeutics landscape for rare genetic disorders
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82. Immunology of SARS-CoV-2 infections and vaccines
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83. Messenger ribonucleic acid vaccines against infectious diseases: current concepts and future prospects
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84. mRNA vaccines as cancer therapies
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85. Synergistic effect of nucleoside modification and ionizable lipid composition on translation and immune responses to mRNA vaccines
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86. In Situ Chimeric Antigen Receptor Macrophage Therapy via Co-Delivery of mRNA and Immunostimulant
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87. Recent Advances in Messenger Ribonucleic Acid (mRNA) Vaccines and Their Delivery Systems: A Review
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88. A Novel mRNA-Mediated and MicroRNA-Guided Approach to Specifically Eradicate Drug-Resistant Hepatocellular Carcinoma Cell Lines by Se-Methylselenocysteine
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89. Innate sensing of mRNA vaccines
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90. Engineering ionizable lipids for rapid biodegradation balances mRNA vaccine efficacy and tolerability
    Julien Couture‐Senécal, Grayson Tilstra, Omar F. Khan · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
91. Protective RNA nanovaccines against Mycobacterium avium subspecies hominissuis
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92. Immunogenicity and efficacy of vaccine boosters against SARS-CoV-2 Omicron subvariant BA.5 in male Syrian hamsters
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93. Messenger RNA rescues medium-chain acyl-CoA dehydrogenase deficiency in fibroblasts from patients and a murine model
    Xuejun Zhao, Al-Walid A. Mohsen, Stephanie J. Mihalik, Keaton J. Solo, Shakuntala Basu, Ermal Aliu, Huifang Shi, Catherine Kochersberger, Anuradha Karunanidhi, Clinton Van’t Land et al. · 2023 · Human Molecular Genetics
94. Messenger RNA Therapy for Female Reproductive Health
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95. Therapeutic applications of cell engineering using mRNA technology
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96. Controlling reactogenicity while preserving immunogenicity from a self-amplifying RNA vaccine by modulating nucleocytoplasmic transport
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97. Ribonuclease activity undermines immune sensing of naked extracellular RNA
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98. Lipid Nanoparticles Formulated with a Novel Cholesterol-Tailed Ionizable Lipid Markedly Increase mRNA Delivery Both in vitro and in vivo
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99. The legacy of mRNA engineering: A lineup of pioneers for the Nobel Prize
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100. Decrypting the Immune Symphony for RNA Vaccines
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