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The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1
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Pirfenidone inhibits HSC activation and liver fibrosis by targeting glutaredoxin-1 and reducing Smad3 glutathionylation.
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Pirfenidone's main anti-fibrotic efficacy in the liver is mostly attributed to suppression of HSC activation.
“but its main anti-fibrotic efficacy in the liver is mostly attributed to suppression of HSC activation (138, 139).”
From Targeting macrophages in liver fibrosis (2026) · cites this paper as [139]
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Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment
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A bivalent anti-CTGF aptamer modulates multiple signaling pathways to attenuate liver fibrosis
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Glutaredoxin 1 promotes intestinal epithelial cell copper toxicity in inflammatory bowel disease
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Metadata
- Authors
- Xi, Y., Li, Y., Xu, P., Li, S., Liu, Z., Tung, H.-C., Cai, X., Wang, J., Huang, H., Wang, M., Xu, M., Ren, S., Li, S., Zhang, M., Lee, Y. J., Huang, L., Yang, D., He, J., Huang, Z., & Xie, W.
- Affiliations
- Sun Yat-sen University (CN)
- Sichuan University (CN)
- University of Pittsburgh (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- He, Jinhan
- Huang, Zhiying
- Xie, Wen
- ORCID
- Venue
- Science Advances
- Published
- 2021-09-03
- Volume
- 7
- Issue
- 36
- Pages
- eabg9241-eabg9241
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC8442864
- OpenAlex
- W3198780045
- Cited by
- 67
- References
- 46
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 16 · 2023: 14 · 2022: 10
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Science Advances (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- University of Pittsburgh
- Sun Yat-sen University
- National Institutes of Health
- University of Pittsburgh School of Pharmacy
- National Institute of Environmental Health Sciences (R35ES030429)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- pirfenidone, glutaredoxin 1, liver fibrosis, protein glutathionylation, hepatic stellate cell activation, Smad3, glutathione, oxidative stress, antifibrotic therapy, therapeutic target, biomarkers
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