Cited by 67Liver physiology and pathologyRedox biology and oxidative stressDrug-Induced Hepatotoxicity and Protection

The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.

The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1

Open access

Abstract

Pirfenidone inhibits HSC activation and liver fibrosis by targeting glutaredoxin-1 and reducing Smad3 glutathionylation.

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Integrity signals

Registry

Crossref · 10.1126/sciadv.abg9241

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

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  • Pirfenidone's main anti-fibrotic efficacy in the liver is mostly attributed to suppression of HSC activation.

    “but its main anti-fibrotic efficacy in the liver is mostly attributed to suppression of HSC activation (138, 139).”

    From Targeting macrophages in liver fibrosis (2026) · cites this paper as [139]

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Citations

Cites

1 retracted

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1 of the 46 references couldn’t be matched to a known paper.

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Metadata

Authors
Xi, Y., Li, Y., Xu, P., Li, S., Liu, Z., Tung, H.-C., Cai, X., Wang, J., Huang, H., Wang, M., Xu, M., Ren, S., Li, S., Zhang, M., Lee, Y. J., Huang, L., Yang, D., He, J., Huang, Z., & Xie, W.
Affiliations
  • Sun Yat-sen University (CN)
  • Sichuan University (CN)
  • University of Pittsburgh (US)
  • University of North Carolina at Chapel Hill (US)
Corresponding author
  • He, Jinhan
  • Huang, Zhiying
  • Xie, Wen
Venue
Science Advances
Published
2021-09-03
Volume
7
Issue
36
Pages
eabg9241-eabg9241
ISSN
2375-2548 (ISSN-L)
OpenAlex
W3198780045
Cited by
67
References
46
Citations by year
2026: 13 · 2025: 14 · 2024: 16 · 2023: 14 · 2022: 10
FWCI
5.57
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Science Advances (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Funders
  • University of Pittsburgh
  • Sun Yat-sen University
  • National Institutes of Health
  • University of Pittsburgh School of Pharmacy
  • National Institute of Environmental Health Sciences (R35ES030429)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Keywords
pirfenidone, glutaredoxin 1, liver fibrosis, protein glutathionylation, hepatic stellate cell activation, Smad3, glutathione, oxidative stress, antifibrotic therapy, therapeutic target, biomarkers

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