The DOI matches its Crossref record.
A Proteolytic Transmembrane Signaling Pathway and Resistance to β-Lactams in Staphylococci
Abstract
β-Lactamase and penicillin-binding protein 2a mediate staphylococcal resistance to β-lactam antibiotics, which are otherwise highly clinically effective. Production of these inducible proteins is regulated by a signal-transducing integral membrane protein and a transcriptional repressor. The signal transducer is a fusion protein with penicillin-binding and zinc metalloprotease domains. The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which autoactivates, and the repressor, which is inactivated, unblocking gene transcription. Compounds that disrupt this regulatory pathway could restore the activity of β-lactam antibiotics against drug-resistant strains of staphylococci.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Mobile Genetic Elements Associated with Antimicrobial Resistance
Partridge, S. R., Kwong, S. M., Firth, N., & Jensen, S. O. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00088-17 · Cited by 2,751
Genomic Basis for Methicillin Resistance in Staphylococcus aureus
Hiramatsu, K., Ito, T., Tsubakishita, S., Sasaki, T., Takeuchi, F., Morimoto, Y., Katayama, Y., Matsuo, M., Kuwahara-Arai, K., Hishinuma, T., et al. (2013) · Infection & Chemotherapy · doi:10.3947/ic.2013.45.2.117 · Cited by 189
Mehta, S., Singh, C., Plata, K. B., Chanda, P. K., Paul, A., Riosa, S., Rosato, R. R., & Rosato, A. E. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01525-12 · Cited by 142
Metadata
- Authors
- Zhang, H. Z., Hackbarth, C. J., Chansky, K. M., & Chambers, H. F.
- Venue
- Science
- Published
- 2001-03-09
- Volume
- 291
- Issue
- 5510
- Pages
- 1962-1965
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2148663866
- Cited by
- 252
- References
- 0
- FWCI
- 10.47
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A Proteolytic Transmembrane Signaling Pathway and Resistance to β-Lactams in Staphylococci. https://app.cochat.ai/papers/10.1126/science.1055144
- The paper
- Zhang, H. Z., Hackbarth, C. J., Chansky, K. M., & Chambers, H. F. (2001). A Proteolytic Transmembrane Signaling Pathway and Resistance to β-Lactams in Staphylococci. Science. https://doi.org/10.1126/science.1055144
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
