Cited by 189Antimicrobial Resistance in StaphylococcusAntibiotic Resistance in BacteriaBacterial Genetics and Biotechnology

Genomic Basis for Methicillin Resistance in Staphylococcus aureus

Open access
Hiramatsu, Keiichi, Ito, Teruyo, Tsubakishita, Sae, Sasaki, Takashi, Takeuchi, Fumihiko, Morimoto, Yuh, Katayama, Yuki, Matsuo, Miki +3 more·2013·Infection & Chemotherapy

Abstract

Since the discovery of the first strain in 1961 in England, MRSA, the most notorious multidrug-resistant hospital pathogen, has spread all over the world. MRSA repeatedly turned down the challenges by number of chemotherapeutics, the fruits of modern organic chemistry. Now, we are in short of effective therapeutic agents against MRSA prevailing among immuno-compromised patients in the hospital. On top of this, we recently became aware of the rise of diverse clones of MRSA, some of which have increased pathogenic potential compared to the classical hospital-associated MRSA, and the others from veterinary sources. They increased rapidly in the community, and started menacing otherwise healthy individuals by causing unexpected acute infection. This review is intended to provide a whole picture of MRSA based on its genetic makeup as a versatile pathogen and our tenacious colonizer.

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Crossref · 10.3947/ic.2013.45.2.117

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  • To date, 11 different SCCmec allotypes have been described with varying degrees of genetic homology and different sizes, insertion sequences and accompanying resistance genes.

    “To date, 11 different SCCmec allotypes have been described with varying degrees of genetic homology and different sizes, insertion sequences and accompanying resistance genes (68, 69).”

    From Mechanisms of Antibiotic Resistance (2016) · cites this paper as [68]

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Authors
Hiramatsu, K., Ito, T., Tsubakishita, S., Sasaki, T., Takeuchi, F., Morimoto, Y., Katayama, Y., Matsuo, M., Kuwahara-Arai, K., Hishinuma, T., & Baba, T.
Affiliations
  • Juntendo University (JP)
  • Rakuno Gakuen University (JP)
  • National Institute of Infectious Diseases (JP)
  • Department of Bacteriology, Juntendo University, Tokyo, Japan.
Corresponding author
Hiramatsu, Keiichi
Venue
Infection & Chemotherapy
Publisher
XMLink
Published
2013
Volume
45
Issue
2
Pages
117
ISSN
  • 1598-8112 (ISSN-L)
  • 2093-2340
  • 2092-6448
OpenAlex
W1969730343
Cited by
189
References
114
Citations by year
2026: 6 · 2025: 14 · 2024: 14 · 2023: 17 · 2022: 16 · 2021: 17 · 2020: 20 · 2019: 25 · 2018: 16 · 2017: 9 · 2016: 15 · 2015: 12 · 2014: 8
FWCI
1.48
Type
journal article
Language
en
Open access
Locations
  • Infection and Chemotherapy (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Institutional Repositories DataBase (IRDB) (publishedVersion, other-oa)
Funders
  • Ministry of Education, Culture, Sports, Science and Technology (S1201013)
  • Japan Society for the Promotion of Science (24780298)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
methicillin resistance, Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, multidrug resistance, antimicrobial resistance, MRSA clones, community-acquired MRSA, hospital-acquired MRSA, bacterial genomics, pathogenicity, immunocompromised patients

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