The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Protein Design of an HIV-1 Entry Inhibitor
Abstract
Human immunodeficiency virus type–1 (HIV-1) membrane fusion is promoted by the formation of a trimer-of-hairpins structure that brings the amino- and carboxyl-terminal regions of the gp41 envelope glycoprotein ectodomain into close proximity. Peptides derived from the carboxyl-terminal region (called C-peptides) potently inhibit HIV-1 entry by binding to the gp41 amino-terminal region. To test the converse of this inhibitory strategy, we designed a small protein, denoted 5-Helix, that binds the C-peptide region of gp41. The 5-Helix protein displays potent (nanomolar) inhibitory activity against diverse HIV-1 variants and may serve as the basis for a new class of antiviral agents. The inhibitory activity of 5-Helix also suggests a strategy for generating an HIV-1 neutralizing antibody response that targets the carboxyl-terminal region of the gp41 ectodomain.
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1 retracted
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Self-citationAtomic structure of the ectodomain from HIV-1 gp41
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Self-citationA conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1
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Self-citation
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Virus entry: molecular mechanisms and biomedical applications
Dimitrov, D. S. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro817 · Cited by 701
Small Molecules Blocking the Entry of Severe Acute Respiratory Syndrome Coronavirus into Host Cells
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Learning the language of viral evolution and escape
Hie, B., Zhong, E. D., Berger, B., & Bryson, B. (2021) · Science · doi:10.1126/science.abd7331 · Cited by 361
Realities and enigmas of human viral influenza: pathogenesis, epidemiology and control.
HILLEMAN, M. (2002) · Vaccine · doi:10.1016/s0264-410x(02)00254-2 · Cited by 319
Discovery and Optimization of a Natural HIV-1 Entry Inhibitor Targeting the gp41 Fusion Peptide
Münch, J., Ständker, L., Adermann, K., Schulz, A., Schindler, M., Chinnadurai, R., Pöhlmann, S., Chaipan, C., Biet, T., Peters, T., et al. (2007) · Cell · doi:10.1016/j.cell.2007.02.042 · Cited by 261
Metadata
- Authors
- Root, M. J., Kay, M. S., & Kim, P. S.
- Venue
- Science
- Published
- 2001-02-02
- Volume
- 291
- Issue
- 5505
- Pages
- 884-888
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2075009216
- Cited by
- 391
- References
- 32
- FWCI
- 10.95
- Type
- journal article
- Language
- en
- Open access
- closed
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