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Fusion-Competent Vaccines: Broad Neutralization of Primary Isolates of HIV
Abstract
Current recombinant human immunodeficiency virus (HIV) gp120 protein vaccine candidates are unable to elicit antibodies capable of neutralizing infectivity of primary isolates from patients. Here, “fusion-competent” HIV vaccine immunogens were generated that capture the transient envelope-CD4-coreceptor structures that arise during HIV binding and fusion. In a transgenic mouse immunization model, these formaldehyde-fixed whole-cell vaccines elicited antibodies capable of neutralizing infectivity of 23 of 24 primary HIV isolates from diverse geographic locations and genetic clades A to E. Development of these fusion-dependent immunogens may lead to a broadly effective HIV vaccine.
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Citations
Cited by
International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors
Murphy, P. M., Baggiolini, M., Charo, I. F., Hébert, C. A., Horuk, R., Matsushima, K., Miller, L. H., Oppenheim, J. J., & Power, C. A. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01439-x · Cited by 1,817
Protein Design of an HIV-1 Entry Inhibitor
Root, M. J., Kay, M. S., & Kim, P. S. (2001) · Science · doi:10.1126/science.1057453 · Cited by 391
Realities and enigmas of human viral influenza: pathogenesis, epidemiology and control.
HILLEMAN, M. (2002) · Vaccine · doi:10.1016/s0264-410x(02)00254-2 · Cited by 319
Recent Progress in Herpes Simplex Virus Immunobiology and Vaccine Research
Koelle, D. M., & Corey, L. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.1.96-113.2003 · Cited by 263
Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein
Hoffman, T. L., LaBranche, C. C., Zhang, W., Canziani, G., Robinson, J., Chaiken, I., Hoxie, J. A., & Doms, R. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6359 · Cited by 263
Metadata
- Authors
- LaCasse, R. A., Follis, K. E., Trahey, M., Scarborough, J. D., Littman, D. R., & Nunberg, J. H.
- Venue
- Science
- Published
- 1999-01-15
- Volume
- 283
- Issue
- 5400
- Pages
- 357-362
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2063808707
- Cited by
- 205
- References
- 0
- FWCI
- 15.82
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- closed
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- CoChat. (2026). Citation check: Fusion-Competent Vaccines: Broad Neutralization of Primary Isolates of HIV. https://app.cochat.ai/papers/10.1126/science.283.5400.357
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- LaCasse, R. A., Follis, K. E., Trahey, M., Scarborough, J. D., Littman, D. R., & Nunberg, J. H. (1999). Fusion-Competent Vaccines: Broad Neutralization of Primary Isolates of HIV. Science. https://doi.org/10.1126/science.283.5400.357
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
