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A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function
Abstract
The Drosophila melanogaster gene insulin-like receptor ( InR ) is homologous to mammalian insulin receptors as well as to Caenorhabditis elegans daf-2 , a signal transducer regulating worm dauer formation and adult longevity. We describe a heteroallelic, hypomorphic genotype of mutant InR , which yields dwarf females with up to an 85% extension of adult longevity and dwarf males with reduced late age-specific mortality. Treatment of the long-lived InR dwarfs with a juvenile hormone analog restores life expectancy toward that of wild-type controls. We conclude that juvenile hormone deficiency, which results from InR signal pathway mutation, is sufficient to extend life-span, and that in flies, insulin-like ligands nonautonomously mediate aging through retardation of growth or activation of specific endocrine tissue.
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Cited by
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Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P., & Le Bouc, Y. (2003) · Nature · doi:10.1038/nature01298 · Cited by 2,109
Suppression of Aging in Mice by the Hormone Klotho
Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935
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Metadata
- Authors
- Tatar, M., Kopelman, A., Epstein, D., Tu, M.-P., Yin, C.-M., & Garofalo, R. S.
- Venue
- Science
- Published
- 2001-04-06
- Volume
- 292
- Issue
- 5514
- Pages
- 107-110
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2049009766
- Cited by
- 1,628
- References
- 0
- FWCI
- 23.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tatar, M., Kopelman, A., Epstein, D., Tu, M.-P., Yin, C.-M., & Garofalo, R. S. (2001). A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function. Science. https://doi.org/10.1126/science.1057987
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