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Ventroptin: A BMP-4 Antagonist Expressed in a Double-Gradient Pattern in the Retina
Abstract
In the visual system, the establishment of the anteroposterior and dorsoventral axes in the retina and tectum during development is important for topographic retinotectal projection. We identified chick Ventroptin, an antagonist of bone morphogenetic protein 4 (BMP-4), which is mainly expressed in the ventral retina, not only with a ventral high–dorsal low gradient but also with a nasal high–temporal low gradient at later stages. Misexpression of Ventroptin altered expression patterns of several topographic genes in the retina and projection of the retinal axons to the tectum along both axes. Thus, the topographic retinotectal projection appears to be specified by the double-gradient molecule Ventroptin along the two axes.
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Cited by
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Bragdon, B., Moseychuk, O., Saldanha, S., King, D., Julian, J., & Nohe, A. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2010.10.003 · Cited by 691
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Balemans, W., & Van Hul, W. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0779 · Cited by 621
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Metadata
- Authors
- Sakuta, H., Suzuki, R., Takahashi, H., Kato, A., Shintani, T., Iemura, S.-I., Yamamoto, T. S., Ueno, N., & Noda, M.
- Venue
- Science
- Published
- 2001-07-06
- Volume
- 293
- Issue
- 5527
- Pages
- 111-115
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2008165339
- Cited by
- 207
- References
- 0
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sakuta, H., Suzuki, R., Takahashi, H., Kato, A., Shintani, T., Iemura, S.-I., Yamamoto, T. S., Ueno, N., & Noda, M. (2001). Ventroptin: A BMP-4 Antagonist Expressed in a Double-Gradient Pattern in the Retina. Science. https://doi.org/10.1126/science.1058379
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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