Transcriptional regulation of vertebrate axon guidance and synapse formation

Polleux, Franck; Ince-Dunn, Gulayse; Ghosh, Anirvan

doi:10.1038/nrn2118

Cited by 168Axon Guidance and Neuronal SignalingNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Transcriptional regulation of vertebrate axon guidance and synapse formation

Polleux, Franck, Ince-Dunn, Gulayse, Ghosh, Anirvan·2007·Nature Reviews Neuroscience

DOI 10.1038/nrn2118

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Abstract

The establishment of functional neural connections requires the growth of axons to specific target areas and the formation of synapses with appropriate synaptic partners. Several molecules that regulate axon guidance and synapse formation have been identified in the past decade, but it is unclear how a relatively limited number of factors can specify a large number of connections. Recent evidence indicates that transcription factors make a crucial contribution to the specification of connections in the nervous system by coordinating the response of neurons to guidance molecules and neurotransmitters.

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Authors: Polleux, F., Ince-Dunn, G., & Ghosh, A.
Affiliations: University of North Carolina at Chapel Hill (US)
Rockefeller University (US)
University of California San Diego (US)
Corresponding author: Ghosh, Anirvan
ORCID: Polleux, Franck
Ince-Dunn, Gulayse
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2007-05
Volume: 8
Issue: 5
Pages: 331-340
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn2118
OpenAlex: W2036981746
Cited by: 168
References: 91
Citations by year: 2026: 3 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 9 · 2017: 10 · 2016: 4 · 2015: 5 · 2014: 15 · 2013: 19 · 2012: 12
FWCI: 1.21
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: transcription factors, axon guidance, synaptogenesis, neuronal connectivity, transcriptional regulation, guidance molecules, neurotransmitters, neural circuit formation, vertebrate nervous system
MeSH terms: Animals, Axons, Models, Biological, Neurons, Synapses, Transcription Factors, Transcription, Genetic, Vertebrates, Transcriptional Activation, Organogenesis

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Transcriptional regulation of vertebrate axon guidance and synapse formation

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