The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Enforcement of Temporal Fidelity in Pyramidal Cells by Somatic Feed-Forward Inhibition
Abstract
The temporal resolution of neuronal integration depends on the time window within which excitatory inputs summate to reach the threshold for spike generation. Here, we show that in rat hippocampal pyramidal cells this window is very narrow (less than 2 milliseconds). This narrowness results from the short delay with which disynaptic feed-forward inhibition follows monosynaptic excitation. Simultaneous somatic and dendritic recordings indicate that feed-forward inhibition is much stronger in the soma than in the dendrites, resulting in a broader integration window in the latter compartment. Thus, the subcellular partitioning of feed-forward inhibition enforces precise coincidence detection in the soma, while allowing dendrites to sum incoming activity over broader time windows.
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In the citing paper
“the latency of disynaptic inhibition, which will include the latency in exciting the PV cell is less than 2 ms”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Pouille and Scanziani, 2001
In the citing paper
“A circuit remarkably similar in many details to the one mediating thalamocortical communication is involved in CA3 to CA1 communication in the hippocampus (Pouille and Scanziani, 2001).”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Pouille and Scanziani, 2001
In the citing paper
“This pattern of activity creates a compound synaptic event that drives spiking with much greater temporal precision than could be achieved by excitation alone (Pouille et al., 2009; Pouille and Scanziani, 2001).”
From Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops (2016) · cites this paper as Pouille and Scanziani, 2001
In the citing paper
“In most circuits the short latency of feedforward inhibition enforces a narrow temporal window for action potential firing in principal cells (922).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [922]
In the citing paper
“Pouille and Scanziani (922) elegantly demonstrated that the bulk of feedforward inhibitory inputs arise through perisomatic fast spiking basket cells and that inhibition onto dendritic compartments was modest by comparison.”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [922]
Citations
Cites
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Cited by
Sorted by citations
Interneurons of the neocortical inhibitory system
Markram, H., Toledo-Rodriguez, M., Wang, Y., Gupta, A., Silberberg, G., & Wu, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1519 · Cited by 2,954
GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits
Tremblay, R., Lee, S., & Rudy, B. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.033 · Cited by 2,033
Critical period plasticity in local cortical circuits
Hensch, T. K. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1787 · Cited by 2,323
Cortical inhibitory neurons and schizophrenia
Lewis, D. A., Hashimoto, T., & Volk, D. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1648 · Cited by 2,297
Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors
Farrant, M., & Nusser, Z. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1625 · Cited by 2,081
Metadata
- Authors
- Pouille, F., & Scanziani, M.
- Affiliations
- Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
- University of Zurich (CH)
- Corresponding author
- Scanziani, Massimo
- ORCID
- Scanziani, Massimo
- Venue
- Science
- Published
- 2001-08-10
- Volume
- 293
- Issue
- 5532
- Pages
- 1159-1163
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2067501282
- Cited by
- 1,097
- References
- 1
- Citations by year
- 2026: 25 · 2025: 33 · 2024: 33 · 2023: 51 · 2022: 51 · 2021: 40 · 2020: 41 · 2019: 33 · 2018: 54 · 2017: 56 · 2016: 56 · 2015: 62 · 2014: 62 · 2013: 63 · 2012: 62
- FWCI
- 8.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- temporal fidelity, feedforward inhibition, hippocampal pyramidal neurons, coincidence detection, somatic inhibition, dendritic integration, synaptic delay, disynaptic inhibition
- MeSH terms
- Action Potentials, Animals, Axons, Bicuculline, Dendrites, Electric Stimulation, Evoked Potentials, Hippocampus, Interneurons, Neural Inhibition, Synaptic Transmission, Pyridazines, Receptors, GABA-A, Time Factors, Rats, Wistar, Pyramidal Cells, Patch-Clamp Techniques, GABA Antagonists, Excitatory Postsynaptic Potentials, Rats, GABA-A Receptor Antagonists, In Vitro Techniques
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