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Identification of a Gene Associated with Bt Resistance in Heliothis virescens
Abstract
Transgenic crops producing insecticidal toxins from Bacillus thuringiensis (Bt) are widely used for pest control. Bt-resistant insect strains have been studied, but the molecular basis of resistance has remained elusive. Here, we show that disruption of a cadherin-superfamily gene by retrotransposon-mediated insertion was linked to high levels of resistance to the Bt toxin Cry1Ac in the cotton pest Heliothis virescens . Monitoring the early phases of Bt resistance evolution in the field has been viewed as crucial but extremely difficult, especially when resistance is recessive. Our findings enable efficient DNA-based screening for resistant heterozygotes by directly detecting the recessive allele.
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Cited by
Molecular Mechanisms of Metabolic Resistance to Synthetic and Natural Xenobiotics
Li, X., Schuler, M. A., & Berenbaum, M. R. (2007) · Annual Review of Entomology · doi:10.1146/annurev.ento.51.110104.151104 · Cited by 2,109
Mao, Y.-B., Cai, W.-J., Wang, J.-W., Hong, G.-J., Tao, X.-Y., Wang, L.-J., Huang, Y.-P., & Chen, X.-Y. (2007) · Nature Biotechnology · doi:10.1038/nbt1352 · Cited by 1,358
Humans as the World's Greatest Evolutionary Force
Palumbi, S. R. (2001) · Science · doi:10.1126/science.293.5536.1786 · Cited by 1,290
Insect resistance management in GM crops: past present and future
Bates, S. L., Zhao, J.-Z., Roush, R. T., & Shelton, A. M. (2005) · Nature Biotechnology · doi:10.1038/nbt1056 · Cited by 577
Full crop protection from an insect pest by expression of long double-stranded RNAs in plastids
Zhang, J., Khan, S. A., Hasse, C., Ruf, S., Heckel, D. G., & Bock, R. (2015) · Science · doi:10.1126/science.1261680 · Cited by 471
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Metadata
- Authors
- Gahan, L. J., Gould, F., & Heckel, D. G.
- Venue
- Science
- Published
- 2001-08-03
- Volume
- 293
- Issue
- 5531
- Pages
- 857-860
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2075626220
- Cited by
- 610
- References
- 0
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- closed
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