Insect resistance management in GM crops: past present and future

Bates, Sarah L; Zhao, Jian-Zhou; Roush, Richard T; Shelton, Anthony M

doi:10.1038/nbt1056

Cited by 577Insect Resistance and GeneticsGenetically Modified Organisms ResearchInsect-Plant Interactions and Control

Insect resistance management in GM crops: past present and future

Bates, Sarah L, Zhao, Jian-Zhou, Roush, Richard T, Shelton, Anthony M·2005·Nature Biotechnology

DOI 10.1038/nbt1056

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Abstract

Transgenic plants expressing insecticidal proteins from the bacterium Bacillus thuringiensis (Bt) were first commercialized in 1996 amid concern from some scientists, regulators and environmentalists that the widespread use of Bt crops would inevitably lead to resistance and the loss of a 'public good,' specifically, the susceptibility of insect pests to Bt proteins. Eight years later, Bt corn and cotton have been grown on a cumulative area >80 million ha worldwide. Despite dire predictions to the contrary, resistance to a Bt crop has yet to be documented, suggesting that resistance management strategies have been effective thus far. However, current strategies to delay resistance remain far from ideal. Eight years without resistance provides a timely opportunity for researchers, regulators and industry to reassess the risk of resistance and the most effective strategies to preserve Bt and other novel insect-resistant crops in development.

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Tissue-specific and inducible promoters may help limit exposure to natural enemies and can be used for resistance management.
“Other examples of nonconstitutive promoters include tissue-specific and inducible promoters that may help not only limit exposure to natural enemies but can be used for resistance management (Bates et al., 2005).”
From Genetically engineered crops help support conservation biological control (2019) · cites this paper as Bates et al., 2005

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Authors: Bates, S. L., Zhao, J.-Z., Roush, R. T., & Shelton, A. M.
Affiliations: Cornell University (US)
University of California, Davis (US)
Corresponding author: Shelton, Anthony M
ORCID: Shelton, Anthony M
Venue: Nature Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2005-01
Volume: 23
Issue: 1
Pages: 57-62
ISSN: 0733-222X (ISSN-L)
1087-0156
1546-1696
DOI: 10.1038/nbt1056
OpenAlex: W2120395741
Cited by: 577
References: 65
Citations by year: 2026: 6 · 2025: 4 · 2024: 10 · 2023: 17 · 2022: 14 · 2021: 18 · 2020: 21 · 2019: 25 · 2018: 23 · 2017: 25 · 2016: 41 · 2015: 35 · 2014: 33 · 2013: 33 · 2012: 37
FWCI: 16.33
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Biotechnology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Insect Resistance and Genetics
Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetically Modified Organisms Research
Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect-Plant Interactions and Control
Keywords: insect resistance management, Bt crops, Bacillus thuringiensis, transgenic plants, insecticidal proteins, insect resistance, Bt maize, Bt cotton, resistance risk assessment
MeSH terms: Animals, Bacillus thuringiensis, Bacterial Toxins, Heterozygote, Insecticide Resistance, Insecta, Models, Biological, Time Factors, Crops, Agricultural, Transgenes, Plants, Genetically Modified

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Insect resistance management in GM crops: past present and future

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