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A Gene Expression Map for Caenorhabditis elegans
Abstract
We have assembled data from Caenorhabditis elegans DNA microarray experiments involving many growth conditions, developmental stages, and varieties of mutants. Co-regulated genes were grouped together and visualized in a three-dimensional expression map that displays correlations of gene expression profiles as distances in two dimensions and gene density in the third dimension. The gene expression map can be used as a gene discovery tool to identify genes that are co-regulated with known sets of genes (such as heat shock, growth control genes, germ line genes, and so forth) or to uncover previously unknown genetic functions (such as genomic instability in males and sperm caused by specific transposons).
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Cites
Cluster analysis and display of genome-wide expression patterns
Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 16,184
Cited by
Interactome Networks and Human Disease
Vidal, M., Cusick, M. E., & Barabási, A.-L. (2011) · Cell · doi:10.1016/j.cell.2011.02.016 · Cited by 1,771
A census of human transcription factors: function, expression and evolution
Vaquerizas, J. M., Kummerfeld, S. K., Teichmann, S. A., & Luscombe, N. M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2538 · Cited by 1,573
Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF‐16
McElwee, J., Bubb, K., & Thomas, J. H. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00043.x · Cited by 416
Carter, S. L., Brechbühler, C. M., Griffin, M., & Bond, A. T. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth234 · Cited by 344
Identification and Characterization of a Sphingolipid Δ4-Desaturase Family
Ternes, P., Franke, S., Zähringer, U., Sperling, P., & Heinz, E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202947200 · Cited by 293
Metadata
- Authors
- Kim, S. K., Lund, J., Kiraly, M., Duke, K., Jiang, M., Stuart, J. M., Eizinger, A., Wylie, B. N., & Davidson, G. S.
- Venue
- Science
- Published
- 2001-09-14
- Volume
- 293
- Issue
- 5537
- Pages
- 2087-2092
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2092742937
- Cited by
- 658
- References
- 1
- FWCI
- 20.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kim, S. K., Lund, J., Kiraly, M., Duke, K., Jiang, M., Stuart, J. M., Eizinger, A., Wylie, B. N., & Davidson, G. S. (2001). A Gene Expression Map for Caenorhabditis elegans. Science. https://doi.org/10.1126/science.1061603
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