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Fatty acid desaturases: selecting the dehydrogenation channel

Buist, P. H. (2004) · Natural Product Reports · doi:10.1039/b302094k · Cited by 123 · see citing works

DEGS1-associated aberrant sphingolipid metabolism impairs nervous system function in humans

Karsai, G., Kraft, F., Haag, N., Korenke, G. C., Hänisch, B., Othman, A., Suriyanarayanan, S., Steiner, R., Knopp, C., Mull, M., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124159 · Cited by 121 · see citing works

Functional Characterization of a Higher Plant Sphingolipid Δ4-Desaturase: Defining the Role of Sphingosine and Sphingosine-1-Phosphate in Arabidopsis

Michaelson, L. V., Zäuner, S., Markham, J. E., Haslam, R. P., Desikan, R., Mugford, S. G., Albrecht, S., Warnecke, D. C., Sperling, P., Heinz, E., et al. (2008) · PLANT PHYSIOLOGY · doi:10.1104/pp.108.129411 · Cited by 119 · see citing works

DES2 protein is responsible for phytoceramide biosynthesis in the mouse small intestine

OMAE, F., MIYAZAKI, M., ENOMOTO, A., SUZUKI, M., SUZUKI, Y., & SUZUKI, A. (2004) · Biochemical Journal · doi:10.1042/bj20031425 · Cited by 118 · see citing works

Emerging concepts of ganglioside metabolism

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Identification of the human sphingolipid C4‐hydroxylase, hDES2, and its up‐regulation during keratinocyte differentiation

Mizutani, Y., Kihara, A., & Igarashi, Y. (2004) · FEBS Letters · doi:10.1016/s0014-5793(04)00274-1 · Cited by 108 · see citing works

Bioorganic Chemistry of Ceramide

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2-Hydroxy-ceramide synthesis by ceramide synthase family: enzymatic basis for the preference of FA chain length

Mizutani, Y., Kihara, A., Chiba, H., Tojo, H., & Igarashi, Y. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800158-jlr200 · Cited by 106 · see citing works

Molecular mechanisms and regulation of ceramide transport

Perry, R. J., & Ridgway, N. D. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.04.001 · Cited by 105 · see citing works

1-Deoxysphingolipids

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Dihydroceramide desaturase and dihydrosphingolipids: Debutant players in the sphingolipid arena

Fabriàs, G., Munoz-Olaya, J. M., Cingolani, F., Signorelli, P., Casas, J., Gagliostro, V., & Ghidoni, R. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.12.002 · Cited by 104 · see citing works

FVT-1 Is a Mammalian 3-Ketodihydrosphingosine Reductase with an Active Site That Faces the Cytosolic Side of the Endoplasmic Reticulum Membrane

Kihara, A., & Igarashi, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405915200 · Cited by 102 · see citing works

Plant Sphingolipid Metabolism and Function

Luttgeharm, K. D., Kimberlin, A. N., & Cahoon, E. B. (2016) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-319-25979-6_11 · Cited by 100 · see citing works

Loss of the sphingolipid desaturase DEGS1 causes hypomyelinating leukodystrophy

Pant, D. C., Dorboz, I., Schlüter, A., Fourcade, S., Launay, N., Joya, J., Aguilera, S., Yoldi, M. E., Casasnovas, C., Willis, M. J. H., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci123959 · Cited by 99 · see citing works

Enzymes of Sphingolipid metabolism in Drosophila melanogaster

Acharya, U. R., & Acharya, J. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4254-1 · Cited by 95 · see citing works

Myristate-derived d16:0 Sphingolipids Constitute a Cardiac Sphingolipid Pool with Distinct Synthetic Routes and Functional Properties

Russo, S. B., Tidhar, R., Futerman, A. H., & Cowart, L. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.428185 · Cited by 89 · see citing works

A Higher Plant Δ8 Sphingolipid Desaturase with a Preference for (Z)-Isomer Formation Confers Aluminum Tolerance to Yeast and Plants

Ryan, P. R., Liu, Q., Sperling, P., Dong, B., Franke, S., & Delhaize, E. (2007) · PLANT PHYSIOLOGY · doi:10.1104/pp.107.100446 · Cited by 88 · see citing works

The Pathogenic and Therapeutic Implications of Ceramide Abnormalities in Atopic Dermatitis

Fujii, M. (2021) · Cells · doi:10.3390/cells10092386 · Cited by 84 · see citing works

Evolution of the Insect Desaturase Gene Family with an Emphasis on Social Hymenoptera

Helmkampf, M., Cash, E. I., & Gadau, J. R. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu315 · Cited by 79 · see citing works

Increased Dihydroceramide/Ceramide Ratio Mediated by Defective Expression of degs1 Impairs Adipocyte Differentiation and Function

Barbarroja, N., Rodríguez‐Cuenca, S., Nygrén, H., Camargo, A., Pirraco, A., Relat, J., Cuadrado, I., Pellegrinelli, V., Medina‐Gómez, G., López-Pedrera, C., et al. (2014) · Diabetes · doi:10.2337/db14-0359 · Cited by 81 · see citing works

Ceramide Generated by Sphingomyelin Hydrolysis and the Salvage Pathway Is Involved in Hypoxia/Reoxygenation-induced Bax Redistribution to Mitochondria in NT-2 Cells

Jin, J., Hou, Q., Mullen, T. D., Zeidan, Y. H., Bielawski, J., Kraveka, J. M., Bielawska, A. E., Obeid, L. M., Hannun, Y. A., & Hsu, Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801597200 · Cited by 81 · see citing works

Two sphingolipid transfer proteins, CERT and FAPP2: Their roles in sphingolipid metabolism

Yamaji, T., Kumagai, K., Tomishige, N., & Hanada, K. (2008) · IUBMB Life · doi:10.1002/iub.83 · Cited by 80 · see citing works

The metabolism and role of free fatty acids in key physiological processes in insects of medical, veterinary and forensic importance

Kaczmarek, A., & Boguś, M. I. (2021) · PeerJ · doi:10.7717/peerj.12563 · Cited by 76 · see citing works

Plant monounsaturated fatty acids: Diversity, biosynthesis, functions and uses

Kazaz, S., Miray, R., Lepiniec, L., & Baud, S. (2021) · Progress in Lipid Research · doi:10.1016/j.plipres.2021.101138 · Cited by 78 · see citing works

Ganglioside Metabolism in Health and Disease

Sandhoff, R., Schulze, H., & Sandhoff, K. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.01.002 · Cited by 74 · see citing works

Functions of Sphingolipids in Pathogenesis During Host–Pathogen Interactions

Wang, J., Chen, Y., Li, Y.-K., Chen, D., He, J.-F., & Yao, N. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.701041 · Cited by 70 · see citing works

The functional role of sphingomyelin in cell membranes

Slotte, J. P., & Ramstedt, B. (2007) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.200700024 · Cited by 74 · see citing works

Ceramide and Other Sphingolipids in Cellular Responses

Yang, J. J., Yu, Y., Sun, S., & Duerksen-Hughes, P. J. (2004) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:40:3:323 · Cited by 73 · see citing works

Isolation and characterization of fatty acid desaturase genes from peanut (Arachis hypogaea L.)

Chi, X., Yang, Q., Pan, L., Chen, M., He, Y., Yang, Z., & Yu, S. (2011) · Plant Cell Reports · doi:10.1007/s00299-011-1048-4 · Cited by 71 · see citing works

Candida albicans sphingolipid C9-methyltransferase is involved in hyphal elongation

Oura, T., & Kajiwara, S. (2009) · Microbiology · doi:10.1099/mic.0.033985-0 · Cited by 71 · see citing works

Synthesis and Biological Activity of a Novel Inhibitor of Dihydroceramide Desaturase

Munoz-Olaya, J. M., Matabosch, X., Bedia, C., Egido‐Gabás, M., Casas, J., Llebaria, A., Delgado, A., & Fabriàs, G. (2008) · ChemMedChem · doi:10.1002/cmdc.200700325 · Cited by 70 · see citing works

Identification of Fungal Sphingolipid C9-methyltransferases by Phylogenetic Profiling

Ternes, P., Sperling, P., Albrecht, S., Franke, S., Cregg, J. M., Warnecke, D. C., & Heinz, E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m512864200 · Cited by 69 · see citing works

Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway

Alecu, I., Othman, A., Penno, A., Saied, E. M., Arenz, C., von Eckardstein, A., & Hornemann, T. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m072421 · Cited by 68 · see citing works

Biological Roles Played by Sphingolipids in Dimorphic and Filamentous Fungi

Fernandes, C. M., Goldman, G. H., & Poeta, M. D. (2018) · mBio · doi:10.1128/mbio.00642-18 · Cited by 69 · see citing works

Characterization of free endogenous C14 and C16 sphingoid bases from Drosophila melanogaster

Fyrst, H., Herr, D. R., Harris, G. L., & Saba, J. D. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300005-jlr200 · Cited by 67 · see citing works

The selective COX-2 inhibitor celecoxib modulates sphingolipid synthesis

Schiffmann, S., Sandner, J., Schmidt, R., Birod, K., Wobst, I., Schmidt, H., Angioni, C., Geißlinger, G., & Grösch, S. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800122-jlr200 · Cited by 66 · see citing works

Regulation of mammalian desaturases by myristic acid: N-terminal myristoylation and other modulations

Rioux, V., Pédrono, F., & Legrand, P. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.09.005 · Cited by 65 · see citing works

Two Pathways of Sphingolipid Biosynthesis Are Separated in the Yeast Pichia pastoris

Ternes, P., Wobbe, T., Schwarz, M., Albrecht, S., Feussner, K., Riezman, I., Cregg, J. M., Heinz, E., Riezman, H., Feußner, I., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.193094 · Cited by 65 · see citing works

Dihydroceramides: their emerging physiological roles and functions in cancer and metabolic diseases

Lachkar, F., Ferré, P., Foufelle, F., & Papaioannou, A. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00330.2020 · Cited by 64 · see citing works

Temperature increase prevails over acidification in gene expression modulation of amastigote differentiation in Leishmania infantum

Alcolea, P. J., Alonso, A., Gómez, M. J., Sánchez-Gorostiaga, A., Moreno‐Paz, M., González‐Pastor, J. E., Toraño, A., Parro, V., & Larraga, V. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-31 · Cited by 64 · see citing works

Diversity in sphingolipid metabolism across land plants

Haslam, T. M., & Feußner, I. (2021) · Journal of Experimental Botany · doi:10.1093/jxb/erab558 · Cited by 63 · see citing works

Fatty Acid and Hopanoid Adaption to Cold in the Methanotroph Methylovulum psychrotolerans

Bale, N. J., Rijpstra, W. I. C., Sahonero‐Canavesi, D. X., Oshkin, I. Y., Belova, S. E., Dedysh, S. N., & Damsté, J. S. S. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00589 · Cited by 62 · see citing works

SPTLC1 variants associated with ALS produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins

Lone, M. A., Aaltonen, M. J., Zidell, A., Pedro, H. F., Saute, J. A. M., Mathew, S., Mohassel, P., Bönnemann, C. G., Shoubridge, E. A., & Hornemann, T. (2022) · Journal of Clinical Investigation · doi:10.1172/jci161908 · Cited by 61 · see citing works

Plant Sphingolipids: Structure, Synthesis and Function

Chen, M., Cahoon, E. B., García, M. S., Plasencia, J., & Gavilanes‐Ruíz, M. (2009) · Advances in photosynthesis and respiration · doi:10.1007/978-90-481-2863-1_5 · Cited by 61 · see citing works

Synthesis of Cyclopropene Analogues of Ceramide and Their Effect on Dihydroceramide Desaturase

Triola, G., Fabriàs, G., Casas, J., & Llebaria, A. (2003) · The Journal of Organic Chemistry · doi:10.1021/jo030141u · Cited by 61 · see citing works

Ceramide, Stress, and a "LAG" in Aging

Obeid, L. M., & Hannun, Y. A. (2003) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2003.39.pe27 · Cited by 60 · see citing works

Fungal sphingolipids: role in the regulation of virulence and potential as targets for future antifungal therapies

Fernandes, C. M., & Poeta, M. D. (2020) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2020.1792288 · Cited by 59 · see citing works

Sphingolipid hydroxylation in mammals, yeast and plants – An integrated view

Marquês, J. T., Marinho, H. S., & de Almeida, R. F. M. (2018) · Progress in Lipid Research · doi:10.1016/j.plipres.2018.05.001 · Cited by 59 · see citing works

Alteration of the 4-sphingenine scaffolds of ceramides in keratinocyte-specific Arnt-deficient mice affects skin barrier function

Takagi, S., Tojo, H., Tomita, S., Sano, S., Itami, S., Hara, M., Inoue, S., Horie, K., Kondoh, G., Hosokawa, K., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318513 · Cited by 59 · see citing works

Disruption of the sphingolipid Δ8-desaturase gene causes a delay in morphological changes in Candida albicans

Oura, T., & Kajiwara, S. (2008) · Microbiology · doi:10.1099/mic.0.2008/018788-0 · Cited by 58 · see citing works

Fungal Glucosylceramides: From Structural Components to Biologically Active Targets of New Antimicrobials

Nimrichter, L., & Rodrigues, M. L. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00212 · Cited by 56 · see citing works

Genome-wide identification of membrane-bound fatty acid desaturase genes in Gossypium hirsutum and their expressions during abiotic stress

Feng, J., Dong, Y., Liu, W., He, Q., Daud, M. K., Chen, J., & Zhu, S. (2017) · Scientific Reports · doi:10.1038/srep45711 · Cited by 58 · see citing works

Bioactive lipids in the skin barrier mediate its functionality in health and disease

Nicolaou, A., & Kendall, A. C. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108681 · Cited by 56 · see citing works

Dihydroceramide desaturase activity is modulated by oxidative stress

Idkowiak‐Baldys, J., Apraiz, A., Li, L., Rahmaniyan, M., Clarke, C. J., Kraveka, J. M., Asumendi, A., & Hannun, Y. A. (2010) · Biochemical Journal · doi:10.1042/bj20091589 · Cited by 56 · see citing works

A new class of lipid desaturases: Identification of the Δ4 sphingoid base desaturase

Garton, S., Michaelson, L. V., Beaudoin, F., & Napier, J. A. (2002) · Biochemical Society Transactions · doi:10.1042/bst030a122c

Functional Characterization of a Higher Plant Sphingolipid Δ4-Desaturase: Defining the Role of Sphingosine and Sphingosine-1-Phosphate in Arabidopsis

Michaelson, L. V., Zäuner, S., Markham, J. E., Haslam, R. P., Desikan, R., Mugford, S. G., Albrecht, S., Warnecke, D. C., Sperling, P., Heinz, E., et al. (2008) · PLANT PHYSIOLOGY · doi:10.1104/pp.108.129411 · Cited by 119 · see citing works

A new class of lipid desaturase central to sphingolipid biosynthesis and signalling

Napier, J. A., Michaelson, L. V., & Dunn, T. M. (2002) · Trends in Plant Science · doi:10.1016/s1360-1385(02)02348-8 · Cited by 19 · see citing works

Sphingolipid Δ4-Desaturase (DES1) like gene from the ovaries of mud crab, Scylla serrata: molecular inspection and phylogenetic analysis

Sainath, S. B., Venkaiah, K., & Hanuma, R. M. (2026) · Research Journal of Biotechnology · doi:10.25303/214rjbt2430249

Further characterization of Δ8-sphingolipid desaturases from higher plants

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