The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Immunocyte Ca 2+ Influx System Mediated by LTRPC2
Abstract
We characterized an activation mechanism of the human LTRPC2 protein, a member of the transient receptor potential family of ion channels, and demonstrated that LTRPC2 mediates Ca 2+ influx into immunocytes. Intracellular pyrimidine nucleotides, adenosine 5′-diphosphoribose (ADPR), and nicotinamide adenine dinucleotide (NAD), directly activated LTRPC2, which functioned as a Ca 2+ -permeable nonselective cation channel and enabled Ca 2+ influx into cells. This activation was suppressed by intracellular adenosine triphosphate. These results reveal that ADPR and NAD act as intracellular messengers and may have an important role in Ca 2+ influx by activating LTRPC2 in immunocytes.
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Reactive Oxygen Species in Inflammation and Tissue Injury
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TRP channels as cellular sensors
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Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology
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Transient Receptor Potential Channels in the Vasculature
Earley, S., & Brayden, J. E. (2015) · Physiological Reviews · doi:10.1152/physrev.00026.2014 · Cited by 420
TRPM2: a multifunctional ion channel for calcium signalling
Sumoza‐Toledo, A., & Penner, R. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.201855 · Cited by 290
Metadata
- Authors
- Sano, Y., Inamura, K., Miyake, A., Mochizuki, S., Yokoi, H., Matsushime, H., & Furuichi, K.
- Venue
- Science
- Published
- 2001-08-17
- Volume
- 293
- Issue
- 5533
- Pages
- 1327-1330
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2021424485
- Cited by
- 441
- References
- 24
- FWCI
- 8.73
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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