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TRP-PLIK, a Bifunctional Protein with Kinase and Ion Channel Activities
Abstract
We cloned and characterized a protein kinase and ion channel, TRP-PLIK. As part of the long transient receptor potential channel subfamily implicated in control of cell division, it is a protein that is both an ion channel and a protein kinase. TRP-PLIK phosphorylated itself, displayed a wide tissue distribution, and, when expressed in CHO-K1 cells, constituted a nonselective, calcium-permeant, 105-picosiemen, steeply outwardly rectifying conductance. The zinc finger containing α-kinase domain was functional. Inactivation of the kinase activity by site-directed mutagenesis and the channel's dependence on intracellular adenosine triphosphate (ATP) demonstrated that the channel's kinase activity is essential for channel function.
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Metadata
- Authors
- Runnels, L. W., Yue, L., & Clapham, D. E.
- Venue
- Science
- Published
- 2001-02-09
- Volume
- 291
- Issue
- 5506
- Pages
- 1043-1047
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1997808089
- Cited by
- 733
- References
- 0
- FWCI
- 17.16
- Type
- journal article
- Language
- en
- Open access
- closed
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