Recruitment of Mec1 and Ddc1 Checkpoint Proteins to Double-Strand Breaks Through Distinct Mechanisms

The DNA damage response: putting checkpoints in perspective

Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature · doi:10.1038/35044005 · Cited by 3,213

Cell Cycle Checkpoints: Preventing an Identity Crisis

Elledge, S. J. (1996) · Science · doi:10.1126/science.274.5293.1664 · Cited by 2,050

THE DNA REPLICATION FORK IN EUKARYOTIC CELLS

Waga, S., & Stillman, B. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.721 · Cited by 814

Loss of a yeast telomere: Arrest, recovery, and chromosome loss

Sandell, L. J. (1993) · Cell · doi:10.1016/0092-8674(93)90493-a · Cited by 792

Saccharomyces Ku70, Mre11/Rad50, and RPA Proteins Regulate Adaptation to G2/M Arrest after DNA Damage

Lee, S. E., Moore, J. K., Holmes, A. M., Umezu, K., Kolodner, R. D., & Haber, J. E. (1998) · Cell · doi:10.1016/s0092-8674(00)81482-8 · Cited by 784

A Suppressor of Two Essential Checkpoint Genes Identifies a Novel Protein that Negatively Affects dNTP Pools

Zhao, X., Muller, E. G. D., & Rothstein, R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80277-4 · Cited by 728

Conserved domains in DNA repair proteins and evolution of repair systems

Aravind, L. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.5.1223 · Cited by 571

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

Tibbetts, R. S., Cortez, D., Brumbaugh, K. M., Scully, R., Livingston, D., Elledge, S. J., & Abraham, R. T. (2000) · Genes & Development · doi:10.1101/gad.851000 · Cited by 512

Loading of an Mcm Protein onto DNA Replication Origins Is Regulated by Cdc6p and CDKs

Tanaka, T. U., Knapp, D., & Nasmyth, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80526-7 · Cited by 500

CDC5 and CKII Control Adaptation to the Yeast DNA Damage Checkpoint

Toczyski, D. P., Galgoczy, D. J., & Hartwell, L. H. (1997) · Cell · doi:10.1016/s0092-8674(00)80375-x · Cited by 431

Selective tumor killing based on specific DNA-damage response deficiencies

Biss, M., & Xiao, W. (2012) · Cancer Biology & Therapy · doi:10.4161/cbt.18921 · Cited by 13

Differential Dynamics of ATR‐Mediated Checkpoint Regulators

Warmerdam, D. O., Kanaar, R., & Smits, V. A. J. (2010) · Journal of Nucleic Acids · doi:10.4061/2010/319142 · Cited by 12

Ddc1 checkpoint protein and DNA polymerase ɛ interact with nick-containing DNA repair intermediate in cell free extracts of Saccharomyces cerevisiae

Sukhanova, M. V., Dhérin, C., van der Kemp, P. A., Koval, V. V., Boiteux, S., & Lavrik, O. I. (2011) · DNA repair · doi:10.1016/j.dnarep.2011.04.031 · Cited by 11

Differential genetic interactions between Sgs1, DNA-damage checkpoint components and DNA repair factors in the maintenance of chromosome stability

Doerfler, L., Harris, L., Viebranz, E., & Schmidt, K. H. (2011) · Genome Integrity · doi:10.1186/2041-9414-2-8 · Cited by 10

Degradation of Mrc1 promotes recombination-mediated restart of stalled replication forks

Chaudhury, I., & Koepp, D. M. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1249 · Cited by 11

The emerging role of long non-coding RNAs in the drug resistance of colorectal cancer.

Chen, D., & Xu, R. (2018) · Europe PMC (PubMed Central) · Cited by 10

TOWARD MAINTAINING THE GENOME

Nyberg, K. A., Michelson, R. J., Putnam, C. W., & Weinert, T. A. (2002) · Cited by 10

Characterization of the Interaction between Rfa1 and Rad24 in Saccharomyces cerevisiae

Piya, G., Mueller, E. N., Haas, H. K., Ghospurkar, P. L., Wilson, T. M., Jensen, J. L., Colbert, C. L., & Haring, S. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116512 · Cited by 7

Facing Stalled Replication Forks: The Intricacies of Doing the Right Thing

Rudolph, C. J., Schürer, K. A., & Kramer, W. (2006) · Springer eBooks · doi:10.1007/7050_003 · Cited by 7

Methods for Studying Mutagenesis and Checkpoints in Schizosaccharomyces pombe

Kai, M., Taricani, L., & Wang, T. S. ‐. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)09011-7 · Cited by 6

Correlation between Checkpoint Activation and in Vivo Assembly of the Yeast Checkpoint Complex Rad17-Mec3-Ddc1

Giannattasio, M., Sabbioneda, S., Minuzzo, M., Plevani, P., & Muzi-Falconi, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301260200 · Cited by 6

Dissecting the DNA damage response using functional genomics approaches in S. cerevisiae

Davidson, M. B., & Brown, G. W. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.03.010 · Cited by 6

Interaction of Ddc1 and RPA with single-stranded/double-stranded DNA junctions in yeast whole cell extracts: Proteolytic degradation of the large subunit of replication protein A in ddc1Δ strains

Sukhanova, M. V., Dhérin, C., Boiteux, S., & Lavrik, O. I. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.07.002 · Cited by 4

Regulators of ribonucleotide reductase inhibit Ty1 mobility in saccharomyces cerevisiae

O'Donnell, J. P., Gehman, M., & Keeney, J. B. (2010) · Mobile DNA · doi:10.1186/1759-8753-1-23 · Cited by 3

Aluminum-Dependent Root Growth Inhibition as Mediated by DNA-Damage Responses

Sjogren, C. A., & Larsen, P. B. (2015) · Signaling and communication in plants · doi:10.1007/978-3-319-19968-9_3 · Cited by 2

Checkpoint activation and recovery: regulation of the 9–1–1 axis by the PP2A phosphatase

Casari, E., Tisi, R., & Longhese, M. P. (2025) · DNA repair · doi:10.1016/j.dnarep.2025.103854 · Cited by 3

DNA Damage Sensing and Signaling

Durocher, D. (2009) · Springer eBooks · doi:10.1007/978-90-481-2561-6_1 · Cited by 2

Checkpoint Controls Halting the Cell Cycle

Carr, A. M., & Caspari, T. (2004) · Springer eBooks · doi:10.1007/978-3-662-10360-9_4 · Cited by 2

ATM, a paradigm for a stress-responsive signal transducer in higher vertebrate cells

Yamamoto, K.-I., Kobayashi, M., & Shimizu, H. (2006) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-1-4020-4896-8_19 · Cited by 2

Zur Funktion des MPH1-Gens von Saccharomyces cerevisiae bei der rekombinativen Umgehung von replikationsarretierenden DNA-Schäden

Schürer, K. A. (2004) · doi:10.53846/goediss-525 · Cited by 2

Responses to Replication of DNA Damage

Longhese, M. P., & Foiani, M. (2005) · doi:10.1201/9780849352683-47 · Cited by 2

Damage and Replication Stress Responses

Wang, H., Shen, P., & Zhu, W. (2011) · InTech eBooks · doi:10.5772/21986 · Cited by 1

Recognition of DNA Damage as the Initial Step of Eukaryotic Checkpoint Arrest

Siede, W. (2005) · CRC Press eBooks · doi:10.1201/9780849352683.ch36 · Cited by 1

DNA damage signalling in eukaryotes: learning from budding yeast

Menacho-Márquez, M., & Ibañez, J. R. M. (2003) · Revista de Oncología · doi:10.1007/bf02712848 · Cited by 1

Budding Yeast DNA Damage Checkpoint: A Signal Transduction-Mediated Surveillance System

Muzi-Falconi, M., Giannattasio, M., Liberi, G., Pellicioli, A., Plevani, P., & Foiani, M. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50663-x · Cited by 1

DNA damage checkpoint pathways and the maintenance of genome stability in C. elegans

Alpi, A. F. (2004) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.2448 · Cited by 1

Chromosome structure due to phospho-mimetic H2A modulates DDR through increased chromatin mobilityPreprint

Fernández, F. G., Lemos, B. R., Khalil, Y., Batrin, R., Haber, J. E., & Fabre, E. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.25.397356 · Cited by 1

Saccharomyces cerevisiae DNA helicases Mph1, Srs2 and Sgs1 collaborate for the reinitiation of stalled or collapsed replication forks

Panico, E. R. (2006) · doi:10.53846/goediss-148

Mecanismos moleculares involucrados en la citotoxicidad del agente antitumoral beta-lapachona.

Menacho, M. A. (2007) · RiuNet (Universitat Politècnica de València) · doi:10.4995/thesis/10251/1877

Replication fork stability in mammalian cells

Elvers, I. (2011) · KTH Publication Database DiVA (KTH Royal Institute of Technology)

Meiotic Dna Re-Replication And The Recombination Checkpoint

Najor, N. A. (2010) · Human Biology

Avaliação da expressão de genes processadores de danos oxidativos em pacientes com Alzheimer

de Oliveira, D. V. N. P. (2007) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2007.tde-17042009-152311

Dissecting Layers of Mitotic Regulation Essential for Maintaining Genomic Stability

Searle, J. S., & Sánchez, Y. (2007) · Springer eBooks · doi:10.1007/978-1-4020-5963-6_2

Analysis of the role of Cdc14/Flp1 in checkpoint response to genotoxic stress in "Schizosaccharomyces pombe"

Díaz-Cuervo, H. (2008) · Gredos (University of Salamanca) · doi:10.14201/gredos.22507

Synthetically Lethal Interactions Classify Novel Genes in Postreplication Repair in Saccharomyces cerevisiae

Barbour, L. (2005) · University Library - University of Saskatchewan (University of Saskatchewan)

Characterisation of the human DNA damage response and replication protein Topoisomerase IIβ Binding Protein 1 (TopBP1)

Reini, K. (2006)

Meccanismi di controllo della proliferazione delle cellule germinali primordiali

Sorrentino, E. (2007) · Cineca Institutional Research Information System (Tor Vergata University) · doi:10.58015/sorrentino-eleonora_phd2007-05

Genetic and Chemical Genetic Analysis of the Cell Cycle

Yu, L. X. (2009) · TSpace (University of Toronto)

Phosphorylation events surrounding the DNA damage response in "Saccharomyces cerevisiae"

Schleker, T. (2007) · edoc (University of Basel) · doi:10.5451/unibas-004360832

A study on telomere protection and telomerase-and-cap-independent mechanisms of telomere maintenance in yeast Saccharomyces cerevisiae

Карпов, В. Г. (2008) · Knowledge UdeS (Institutional Deposit of the University of Sherbrooke)

Coping with DNA Damage and Replication Stress

Ulrich, H. D. (2009) · Royal Society of Chemistry eBooks · doi:10.1039/9781847559852-00178

Signaling of DNA Replication Stress Through the ATR Checkpoint

Shiotani, B., & Zou, L. (2016) · Springer eBooks · doi:10.1007/978-4-431-55873-6_16 · Cited by 1

Organization, Replication, Transposition, and Repair of DNA

Metzler, D. E., Metzler, C. M., & Sauke, D. J. (2001) · Elsevier eBooks · doi:10.1016/b978-012492543-4/50030-1

Recognition of DNA Damage as the Initial Step of Eukaryotic Checkpoint Arrest

Siede, W. (2005) · doi:10.1201/9780849352683-46

The Rad9.M50 Variant of the DNA Damage Checkpoint Protein Rad9 Regulates the MAP Kinase pathway in the Response to Heat Stress

Oun, R. R. S. (2016) · Bangor University Research Portal (Bangor University)

The Recognition and Mobility of DNA-Double Strand Breaks

Strecker, J. (2016) · TSpace (University of Toronto)

Damage control

Frantz, S. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35103015

EXPLORING GENOME INTEGRITY PATHWAYS IN SACCHAROMYCES CEREVISIAE

Shanmugan, M. K. (2014) · Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · doi:10.13130/shanmugam-muthukumar_phd2014-01-24

Role of Histone Metabolism and Chromatin Structure in DNA Repair

Kari, V. (2014) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-4552

Cell Cycle Checkpoints

(2014) · ASM Press eBooks · doi:10.1128/9781555816704.ch20

Responses to Replication of DNA Damage

Longhese, M. P., & Foiani, M. (2005) · CRC Press eBooks · doi:10.1201/9780849352683.ch37

Faculty Opinions recommendation of Reduced Rif2 and lack of Mec1 target short telomeres for elongation rather than double-strand break repair.

Shore, D., & Ribeyre, C. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.7465956.7758054

Energetically equivalent structural transitions in the Rad17–Rad9–Hus1–Rad1–Rhino complex underlie the sequential progression from activation through maintenance to inactivation of the ATR-dependent DNA damage response

Fukumoto, Y., Yuki, R., & Ogra, Y. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag093

Recombinaison homologue protège contre les défauts de la mitose et la ségrégation des chromosomes déséquilibre causé par le stress de réplication spontanée

Wilhelm, T. (2011) · theses.fr (ABES) · doi:10.70675/8f8f5907z32edz4a84zb3c8zc042507f5b0d

Rôles de la protéine E4F1 dans le contrôle de la réponse aux dommages de l’ADN dans le cancer du sein triple négatif

Batnini, K. (2019) · theses.fr (ABES) · doi:10.70675/1e6a4caaz593dz4037zb362z1237e393c1be

Dpb11 facilitates the colocalization of Mec1-Ddc2 with its activators on gapped DNA

Beckwitt, E. C., Chua, G. N. L., Liu, S., & O’Donnell, M. E. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117660

Reflections on the early days of the DNA damage response pathway in eukaryotes

Elledge, S. J. (2026) · Genetics · doi:10.1093/genetics/iyag202

Dealing with DNA Damage in Different Ways

(2001) · Science Signaling · doi:10.1126/scisignal.1062001tw399

R EPORTS Fig. 5. Association of Mec1 with sites near the

Toczyski, D. P., Galgoczy, D. J., Hartwell, L. H., Demeter, J., Lee, S. E., Haber, J. E., Stearns, T., & Cell, M. (1991)

Two checkpoint complexes are independently recruited to sites of DNA damage in vivo

Melo, J. A., Cohen, J., & Toczyski, D. P. (2001) · Genes & Development · doi:10.1101/gad.903501 · Cited by 384

Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p

Paciotti, V., Lucchini, G., Plevani, P., & Longhese, M. P. (1998) · The EMBO Journal · doi:10.1093/emboj/17.14.4199 · Cited by 132

A role for Ddc1 in signaling meiotic double-strand breaks at the pachytene checkpointPreprint

Hong, E.-J. E., & Roeder, G. S. (2002) · Genes & Development · doi:10.1101/gad.938102 · Cited by 64