The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Dynamic Disruptions in Nuclear Envelope Architecture and Integrity Induced by HIV-1 Vpr
Abstract
Human immunodeficiency virus–1 (HIV-1) Vpr expression halts the proliferation of human cells at or near the G 2 cell-cycle checkpoint. The transition from G 2 to mitosis is normally controlled by changes in the state of phosphorylation and subcellular compartmentalization of key cell-cycle regulatory proteins. In studies of the intracellular trafficking of these regulators, we unexpectedly found that wild-type Vpr, but not Vpr mutants impaired for G 2 arrest, induced transient, localized herniations in the nuclear envelope (NE). These herniations were associated with defects in the nuclear lamina. Intermittently, these herniations ruptured, resulting in the mixing of nuclear and cytoplasmic components. These Vpr-induced NE changes probably contribute to the observed cell-cycle arrest.
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Cites
Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.
Bukrinsky, M. I., Sharova, N., Dempsey, M. P., Stanwick, T. L., Bukrinskaya, A. G., Haggerty, S., & Stevenson, M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.14.6580 · Cited by 607
Balliet, J. W., Kolson, D. L., Eiger, G., Kim, F. M., McGann, K. A., Srinivasan, A., & Collman, R. (1994) · Virology · doi:10.1006/viro.1994.1225 · Cited by 236
Cited by
Dechat, T., Pfleghaar, K., Sengupta, K., Shimi, T., Shumaker, D. K., Solimando, L., & Goldman, R. D. (2008) · Genes & Development · doi:10.1101/gad.1652708 · Cited by 940
Self-citationMechanics and functional consequences of nuclear deformations
Kalukula, Y., Stephens, A. D., Lammerding, J., & Gabriele, S. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00480-z · Cited by 475
A sensitive and specific enzyme-based assay detecting HIV-1 virion fusion in primary T lymphocytes
Cavrois, M., de Noronha, C., & Greene, W. C. (2002) · Nature Biotechnology · doi:10.1038/nbt745 · Cited by 475
Self-citationThe AIM 2 inflammasome: Sensor of pathogens and cellular perturbations
Lugrin, J., & Martinon, F. (2018) · Immunological Reviews · doi:10.1111/imr.12618 · Cited by 333
HIV-1 Vpr-Mediated G2 Arrest Involves the DDB1-CUL4AVPRBP E3 Ubiquitin Ligase
Belzile, J.-P., Duisit, G., Rougeau, N., Mercier, J., Finzi, A., & Cohen, É. A. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030085 · Cited by 189
Metadata
- Authors
- de Noronha, C. M. C., Sherman, M. P., Lin, H. W., Cavrois, M. V., Moir, R. D., Goldman, R. D., & Greene, W. C.
- Venue
- Science
- Published
- 2001-11-02
- Volume
- 294
- Issue
- 5544
- Pages
- 1105-1108
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2169601134
- Cited by
- 276
- References
- 2
- FWCI
- 7.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- de Noronha, C. M. C., Sherman, M. P., Lin, H. W., Cavrois, M. V., Moir, R. D., Goldman, R. D., & Greene, W. C. (2001). Dynamic Disruptions in Nuclear Envelope Architecture and Integrity Induced by HIV-1 Vpr. Science. https://doi.org/10.1126/science.1063957
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