The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Real-Time Single-Molecule Imaging of the Infection Pathway of an Adeno-Associated Virus
Abstract
We describe a method, based on single-molecule imaging, that allows the real-time visualization of the infection pathway of single viruses in living cells, each labeled with only one fluorescent dye molecule. The tracking of single viruses removes ensemble averaging. Diffusion trajectories with high spatial and time resolution show various modes of motion of adeno-associated viruses (AAV) during their infection pathway into living HeLa cells: (i) consecutive virus touching at the cell surface and fast endocytosis; (ii) free and anomalous diffusion of the endosome and the virus in the cytoplasm and the nucleus; and (iii) directed motion by motor proteins in the cytoplasm and in nuclear tubular structures. The real-time visualization of the infection pathway of single AAVs shows a much faster infection than was generally observed so far.
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Cites
Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors
Bartlett, J. S., Wilcher, R., & Samulski, R. J. (2000) · Journal of Virology · doi:10.1128/jvi.74.6.2777-2785.2000 · Cited by 532
Cited by
Virus entry: molecular mechanisms and biomedical applications
Dimitrov, D. S. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro817 · Cited by 701
Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranes
Sergé, A., Bertaux, N., Rigneault, H., & Marguet, D. (2008) · Nature Methods · doi:10.1038/nmeth.1233 · Cited by 632
The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy
Xie, Q., Bu, W., Bhatia, S., Hare, J., Somasundaram, T., Azzi, A., & Chapman, M. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162250899 · Cited by 612
Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles
Schlich, M., Palomba, R., Costabile, G., Mizrahy, S., Pannuzzo, M., Peer, D., & Decuzzi, P. (2021) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10213 · Cited by 387
Direct imaging of lateral movements of AMPA receptors inside synapses
Tardin, C., Cognet, L., Bats, C., Lounis, B., & Choquet, D. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg463 · Cited by 384
Metadata
- Authors
- Seisenberger, G., Ried, M. U., Endreß, T., Büning, H., Hallek, M., & Bräuchle, C.
- Venue
- Science
- Published
- 2001-11-30
- Volume
- 294
- Issue
- 5548
- Pages
- 1929-1932
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2000217017
- Cited by
- 820
- References
- 1
- FWCI
- 25.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Seisenberger, G., Ried, M. U., Endreß, T., Büning, H., Hallek, M., & Bräuchle, C. (2001). Real-Time Single-Molecule Imaging of the Infection Pathway of an Adeno-Associated Virus. Science. https://doi.org/10.1126/science.1064103
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
