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Transitions in Distinct Histone H3 Methylation Patterns at the Heterochromatin Domain Boundaries
Abstract
Eukaryotic genomes are organized into discrete structural and functional chromatin domains. Here, we show that distinct site-specific histone H3 methylation patterns define euchromatic and heterochromatic chromosomal domains within a 47-kilobase region of the mating-type locus in fission yeast. H3 methylated at lysine 9 (H3 Lys 9 ), and its interacting Swi6 protein, are strictly localized to a 20-kilobase silent heterochromatic interval. In contrast, H3 methylated at lysine 4 (H3 Lys 4 ) is specific to the surrounding euchromatic regions. Two inverted repeats flanking the silent interval serve as boundary elements to mark the borders between heterochromatin and euchromatin. Deletions of these boundary elements lead to spreading of H3 Lys 9 methylation and Swi6 into neighboring sequences. Furthermore, the H3 Lys 9 methylation and corresponding heterochromatin-associated complexes prevent H3 Lys 4 methylation in the silent domain.
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Citations
Cites
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
Bell, A. C., & Felsenfeld, G. (2000) · Nature · doi:10.1038/35013100 · Cited by 1,746
Cited by
DNA methylation patterns and epigenetic memory
Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124
The fundamental role of epigenetic events in cancer
Jones, P. A., & Baylin, S. B. (2002) · Nature Reviews Genetics · doi:10.1038/nrg816 · Cited by 5,648
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell · doi:10.1016/j.cell.2004.12.012 · Cited by 4,051
Gene Silencing in Cancer in Association with Promoter Hypermethylation
Herman, J. G., & Baylin, S. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmra023075 · Cited by 3,422
The molecular hallmarks of epigenetic control
Allis, C. D., & Jenuwein, T. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.59 · Cited by 2,809
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Metadata
- Authors
- Noma, K.-I., Allis, C. D., & Grewal, S. I. S.
- Venue
- Science
- Published
- 2001-08-10
- Volume
- 293
- Issue
- 5532
- Pages
- 1150-1155
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2067487392
- Cited by
- 747
- References
- 1
- FWCI
- 26.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- Noma, K.-I., Allis, C. D., & Grewal, S. I. S. (2001). Transitions in Distinct Histone H3 Methylation Patterns at the Heterochromatin Domain Boundaries. Science. https://doi.org/10.1126/science.1064150
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