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Uniform Binding of Aminoacyl-tRNAs to Elongation Factor Tu by Thermodynamic Compensation
Abstract
Elongation factor Tu (EF-Tu) binds all elongator aminoacyl–transfer RNAs (aa-tRNAs) for delivery to the ribosome during protein synthesis. Here, we show that EF-Tu binds misacylated tRNAs over a much wider range of affinities than it binds the corresponding correctly acylated tRNAs, suggesting that the protein exhibits considerable specificity for both the amino acid side chain and the tRNA body. The thermodynamic contributions of the amino acid and the tRNA body to the overall binding affinity are independent of each other and compensate for one another when the tRNAs are correctly acylated. Because certain misacylated tRNAs bind EF-Tu significantly more strongly or weakly than cognate aa-tRNAs, EF-Tu may contribute to translational accuracy.
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A General Method for Site-specific Incorporation of Unnatural Amino Acids into Proteins
Noren, C. J., Anthony-Cahill, S. J., Griffith, M. C., & Schultz, P. G. (1989) · Science · doi:10.1126/science.2649980 · Cited by 1,019
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Park, H.-S., Hohn, M. J., Umehara, T., Guo, L.-T., Osborne, E. M., Benner, J., Noren, C. J., Rinehart, J., & Söll, D. (2011) · Science · doi:10.1126/science.1207203 · Cited by 377
Translation fidelity coevolves with longevity
Ke, Z., Mallik, P., Johnson, A. B., Luna, F., Nevo, E., Zhang, Z. D., Gladyshev, V. N., Seluanov, A., & Gorbunova, V. (2017) · Aging Cell · doi:10.1111/acel.12628 · Cited by 82
A unified model of codon reassignment in alternative genetic codes
Sengupta, S., & Higgs, P. G. (2005) · Genetics · doi:10.1534/genetics.104.037887 · Cited by 53
Improving Acetic Acid Production by Over-Expressing PQQ-ADH in Acetobacter pasteurianus
Wu, X., Yao, H., Cao, L., Zheng, Z., Chen, X., Zhang, M., Wei, Z., Cheng, J., Jiang, S., Pan, L., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01713 · Cited by 32
Metadata
- Authors
- LaRiviere, F. J., Wolfson, A. D., & Uhlenbeck, O. C.
- Venue
- Science
- Published
- 2001-10-05
- Volume
- 294
- Issue
- 5540
- Pages
- 165-168
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993111592
- Cited by
- 330
- References
- 1
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- LaRiviere, F. J., Wolfson, A. D., & Uhlenbeck, O. C. (2001). Uniform Binding of Aminoacyl-tRNAs to Elongation Factor Tu by Thermodynamic Compensation. Science. https://doi.org/10.1126/science.1064242
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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