The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Induction of Dendritic Cell Differentiation by IFN-α in Systemic Lupus Erythematosus
Abstract
Dendritic cells (DCs) are important in regulating both immunity and tolerance. Hence, we hypothesized that systemic lupus erythematosus (SLE), an autoimmune disease characterized by autoreactive B and T cells, may be caused by alterations in the functions of DCs. Consistent with this, monocytes from SLE patients' blood were found to function as antigen-presenting cells, in vitro. Furthermore, serum from SLE patients induced normal monocytes to differentiate into DCs. These DCs could capture antigens from dying cells and present them to CD4-positive T cells. The capacity of SLE patients' serum to induce DC differentiation correlated with disease activity and depended on the actions of interferon-α (IFN-α). Thus, unabated induction of DCs by IFN-α may drive the autoimmune response in SLE.
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The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood
Siegal, F. P., Kadowaki, N., Shodell, M., Fitzgerald-Bocarsly, P. A., Shah, K., Ho, S., Antonenko, S., & Liu, Y.-J. (1999) · Science · doi:10.1126/science.284.5421.1835 · Cited by 2,293
Impairment of T and B Cell Development by Treatment with a Type I Interferon
Lin, Q., Dong, C., & Cooper, M. D. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.1.79 · Cited by 163
Cited by
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Vaccine Adjuvants: Putting Innate Immunity to Work
Coffman, R. L., Sher, A., & Seder, R. A. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.002 · Cited by 1,924
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
Lande, R., Gregorio, J., Facchinetti, V., Chatterjee, B., Wang, Y.-H., Homey, B., Cao, W., Wang, Y.-H., Su, B., Nestle, F. O., et al. (2007) · Nature · doi:10.1038/nature06116 · Cited by 1,910
Tian, J., Avalos, A. M., Mao, S.-Y., Chen, B., Senthil, K., Wu, H., Parroche, P., Drabic, S., Golenbock, D., Sirois, C., et al. (2007) · Nature Immunology · doi:10.1038/ni1457 · Cited by 1,372
Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
Gilliet, M., Cao, W., & Liu, Y.-J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2358 · Cited by 1,190
Metadata
- Authors
- Blanco, P., Palucka, A. K., Gill, M., Pascual, V., & Banchereau, J.
- Venue
- Science
- Published
- 2001-11-16
- Volume
- 294
- Issue
- 5546
- Pages
- 1540-1543
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2065907531
- Cited by
- 1,266
- References
- 2
- FWCI
- 37.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Blanco, P., Palucka, A. K., Gill, M., Pascual, V., & Banchereau, J. (2001). Induction of Dendritic Cell Differentiation by IFN-α in Systemic Lupus Erythematosus. Science. https://doi.org/10.1126/science.1064890
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