The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Defective Antigen Processing in GILT-Free Mice
Abstract
Processing of proteins for major histocompatibility complex (MHC) class II–restricted presentation to CD4-positive T lymphocytes occurs after they are internalized by antigen-presenting cells (APCs). Antigenic proteins frequently contain disulfide bonds, and their reduction in the endocytic pathway facilitates processing. In humans, a gamma interferon–inducible lysosomal thiol reductase (GILT) is constitutively present in late endocytic compartments of APCs. Here, we identified the mouse homolog of GILT and generated a GILT knockout mouse. GILT facilitated the processing and presentation to antigen-specific T cells of protein antigens containing disulfide bonds. The response to hen egg lysozyme, a model antigen with a compact structure containing four disulfide bonds, was examined in detail.
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Inaba, K., Inaba, M., Romani, N., Aya, H., Deguchi, M., Ikehara, S., Muramatsu, S., & Steinman, R. M. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.6.1693 · Cited by 3,738
Current Protocols in Immunology
(2018) · Current Protocols in Immunology · doi:10.1002/(issn)1934-368x · Cited by 3,566
Defective T Cell Differentiation in the Absence of Jnk1
Dong, C., Yang, D. D., Wysk, M., Whitmarsh, A. J., Davis, R. J., & Flavell, R. A. (1998) · Science · doi:10.1126/science.282.5396.2092 · Cited by 584
Self-citationDevelopmental Control of Endocytosis in Dendritic Cells by Cdc42
Garrett, W. S., Chen, L.-M., Kroschewski, R., Ebersold, M., Turley, S., Trombetta, S., Galán, J. E., & Mellman, I. (2000) · Cell · doi:10.1016/s0092-8674(00)00038-6 · Cited by 452
Self-citationArunachalam, B., Phan, U. T., Geuze, H. J., & Cresswell, P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.745 · Cited by 438
Self-citationJNK is required for effector T-cell function but not for T-cell activation
Dong, C., Yang, D. D., Tournier, C., Whitmarsh, A. J., Xu, J., Davis, R. J., & Flavell, R. A. (2000) · Nature · doi:10.1038/35011091 · Cited by 328
Self-citationReduction of disulfide bonds within lysosomes is a key step in antigen processing
Collins, D. S., Unanue, E. R., & Harding, C. V. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.12.4054 · Cited by 244
Gamma-Interferon-inducibleLysosomal Thiol Reductase (GILT)
Phan, U. T., Arunachalam, B., & Cresswell, P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003459200 · Cited by 190
Self-citationJensen, P. E. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.5.1121 · Cited by 95
Large Protein Fragments as Substrates for Endocytic Antigen Capture by MHC Class II Molecules
Castellino, F., Zappacosta, F., Coligan, J. E., & Germain, R. N. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.8.4048 · Cited by 73
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Boes, M., Cerny, J., Massol, R., Op den Brouw, M., Kirchhausen, T., Chen, J., & Ploegh, H. L. (2002) · Nature · doi:10.1038/nature01004 · Cited by 416
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Donoghue, M. J., & Smith, S. A. (2004) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2004.1538 · Cited by 347
Metadata
- Authors
- Maric, M., Arunachalam, B., Phan, U. T., Dong, C., Garrett, W. S., Cannon, K. S., Alfonso, C., Karlsson, L., Flavell, R. A., & Cresswell, P.
- Venue
- Science
- Published
- 2001-11-09
- Volume
- 294
- Issue
- 5545
- Pages
- 1361-1365
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1994136017
- Cited by
- 271
- References
- 15
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Maric, M., Arunachalam, B., Phan, U. T., Dong, C., Garrett, W. S., Cannon, K. S., Alfonso, C., Karlsson, L., Flavell, R. A., & Cresswell, P. (2001). Defective Antigen Processing in GILT-Free Mice. Science. https://doi.org/10.1126/science.1065500
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