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Developmental Control of Endocytosis in Dendritic Cells by Cdc42
Open accessAbstract
Dendritic cells (DCs) developmentally regulate antigen uptake by controlling their endocytic capacity. Immature DCs actively internalize antigen. However, mature DCs are poorly endocytic, functioning instead to present antigens to T cells. We have found that endocytic downregulation reflects a decrease in endocytic activity controlled by Rho family GTPases, especially Cdc42. Blocking Cdc42 function by Toxin B treatment or injection of dominant-negative inhibitors of Cdc42 abrogates endocytosis in immature DCs. In mature DCs, injection of constitutively active Cdc42 or microbial delivery of a Cdc42 nucleotide exchange factor reactivates endocytosis. DCs regulate endogenous levels of Cdc42-GTP with activated Cdc42 detectable only in immature cells. We conclude that DCs developmentally regulate endocytosis at least in part by controlling levels of activated Cdc42.
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Citations
Cites
Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases
Caron, E., & Hall, A. (1998) · Science · doi:10.1126/science.282.5394.1717 · Cited by 1,019
Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes
Cox, D., Chang, P., Zhang, Q., Reddy, P. G., Bokoch, G. M., & Greenberg, S. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.9.1487 · Cited by 436
Cited by
Antigen Presentation and T Cell Stimulation by Dendritic Cells
Guermonprez, P., Valladeau, J., Zitvogel, L., Théry, C., & Amigorena, S. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064828 · Cited by 1,926
Pathways of clathrin-independent endocytosis
Mayor, S., & Pagano, R. E. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2216 · Cited by 1,556
The ins and outs of MHC class II-mediated antigen processing and presentation
Roche, P. A., & Furuta, K. (2015) · Nature reviews. Immunology · doi:10.1038/nri3818 · Cited by 1,207
Shaping cups into phagosomes and macropinosomes
Swanson, J. A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2447 · Cited by 941
Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis
Fitzner, D., Schnaars, M., van Rossum, D., Krishnamoorthy, G., Dibaj, P., Bakhti, M., Regen, T., Hanisch, U.-K., & Simons, M. (2011) · Journal of Cell Science · doi:10.1242/jcs.074088 · Cited by 866
Metadata
- Authors
- Garrett, W. S., Chen, L.-M., Kroschewski, R., Ebersold, M., Turley, S., Trombetta, S., Galán, J. E., & Mellman, I.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2000-08
- Volume
- 102
- Issue
- 3
- Pages
- 325-334
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2122791726
- Cited by
- 452
- References
- 2
- FWCI
- 11.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Garrett, W. S., Chen, L.-M., Kroschewski, R., Ebersold, M., Turley, S., Trombetta, S., Galán, J. E., & Mellman, I. (2000). Developmental Control of Endocytosis in Dendritic Cells by Cdc42. Cell. https://doi.org/10.1016/s0092-8674(00)00038-6
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