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Requirement of Math1 for Secretory Cell Lineage Commitment in the Mouse Intestine
Abstract
The mouse small intestinal epithelium consists of four principal cell types deriving from one multipotent stem cell: enterocytes, goblet, enteroendocrine, and Paneth cells. Previous studies showed that Math1 , a basic helix-loop-helix (bHLH) transcription factor, is expressed in the gut. We find that loss of Math1 leads to depletion of goblet, enteroendocrine, and Paneth cells without affecting enterocytes. Colocalization of Math1 with Ki-67 in some proliferating cells suggests that secretory cells (goblet, enteroendocrine, and Paneth cells) arise from a common progenitor that expresses Math1 , whereas absorptive cells (enterocytes) arise from a progenitor that is Math1 -independent. The continuous rapid renewal of these cells makes the intestinal epithelium a model system for the study of stem cell regeneration and lineage commitment.
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Cited by
van Es, J. H., van Gijn, M. E., Riccio, O., van den Born, M., Vooijs, M., Begthel, H., Cozijnsen, M., Robine, S., Winton, D. J., Radtke, F., et al. (2005) · Nature · doi:10.1038/nature03659 · Cited by 1,543
Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis
Bevins, C. L., & Salzman, N. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2546 · Cited by 1,238
The intestinal crypt, a prototype stem cell compartment
Clevers, H. (2013) · Cell · doi:10.1016/j.cell.2013.07.004 · Cited by 1,223
Canonical Wnt signals are essential for homeostasis of the intestinal epithelium
Pinto, D., Gregorieff, A., Begthel, H., & Clevers, H. (2003) · Genes & Development · doi:10.1101/gad.267103 · Cited by 1,026
Self-Renewal and Cancer of the Gut: Two Sides of a Coin
Radtke, F., & Clevers, H. (2005) · Science · doi:10.1126/science.1104815 · Cited by 690
Metadata
- Authors
- Yang, Q., Bermingham, N. A., Finegold, M. J., & Zoghbi, H. Y.
- Venue
- Science
- Published
- 2001-12-07
- Volume
- 294
- Issue
- 5549
- Pages
- 2155-2158
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2024121049
- Cited by
- 919
- References
- 0
- FWCI
- 12.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yang, Q., Bermingham, N. A., Finegold, M. J., & Zoghbi, H. Y. (2001). Requirement of Math1 for Secretory Cell Lineage Commitment in the Mouse Intestine. Science. https://doi.org/10.1126/science.1065718
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