The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Phosphatase Associated with Metastasis of Colorectal Cancer
Abstract
To gain insights into the molecular basis for metastasis, we compared the global gene expression profile of metastatic colorectal cancer with that of primary cancers, benign colorectal tumors, and normal colorectal epithelium. Among the genes identified, the PRL-3 protein tyrosine phosphatase gene was of particular interest. It was expressed at high levels in each of 18 cancer metastases studied but at lower levels in nonmetastatic tumors and normal colorectal epithelium. In 3 of 12 metastases examined, multiple copies of the PRL-3 gene were found within a small amplicon located at chromosome 8q24.3. These data suggest that the PRL-3 gene is important for colorectal cancer metastasis and provide a new therapeutic target for these intractable lesions.
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Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607
Self-citationLessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919
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Cited by
Chen, R.-X., Chen, X., Xia, L.-P., Zhang, J.-X., Pan, Z.-Z., Ma, X.-D., Han, K., Chen, J.-W., Judde, J.-G., Deas, O., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12651-2 · Cited by 734
Balancing cell adhesion and Wnt signaling, the key role of β-catenin
Brembeck, F. H., Rosário, M., & Birchmeier, W. (2006) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.12.007 · Cited by 668
Liang, C., Xu, L., Song, G., & Liu, Z. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00458j · Cited by 435
Inhibitors of Protein Tyrosine Phosphatases: Next‐Generation Drugs?
Bialy, L., & Waldmann, H. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200461517 · Cited by 420
Haeno, H., Gonen, M., Davis, M. B., Herman, J. M., Iacobuzio-Donahue, C. A., & Michor, F. (2012) · Cell · doi:10.1016/j.cell.2011.11.060 · Cited by 409
Metadata
- Authors
- Saha, S., Bardelli, A., Buckhaults, P., Velculescu, V. E., Rago, C., Croix, B. S., Romans, K. E., Choti, M. A., Lengauer, C., Kinzler, K. W., & Vogelstein, B.
- Venue
- Science
- Published
- 2001-11-09
- Volume
- 294
- Issue
- 5545
- Pages
- 1343-1346
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2100258190
- Cited by
- 648
- References
- 2
- FWCI
- 11.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Saha, S., Bardelli, A., Buckhaults, P., Velculescu, V. E., Rago, C., Croix, B. S., Romans, K. E., Choti, M. A., Lengauer, C., Kinzler, K. W., & Vogelstein, B. (2001). A Phosphatase Associated with Metastasis of Colorectal Cancer. Science. https://doi.org/10.1126/science.1065817
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