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KLF6 , a Candidate Tumor Suppressor Gene Mutated in Prostate Cancer
Abstract
Kruppel-like factor 6 ( KLF6 ) is a zinc finger transcription factor of unknown function. Here, we show that the KLF6 gene is mutated in a subset of human prostate cancer. Loss-of-heterozygosity analysis revealed that one KLF6 allele is deleted in 77% (17 of 22) of primary prostate tumors. Sequence analysis of the retained KLF6 allele revealed mutations in 71% of these tumors. Functional studies confirm that whereas wild-type KLF6 up-regulates p21 (WAF1/CIP1) in a p53-independent manner and significantly reduces cell proliferation, tumor-derived KLF6 mutants do not. Our data suggest that KLF6 is a tumor suppressor gene involved in human prostate cancer.
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Citations
Cited by
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Friedman, S. L. (2008) · Physiological Reviews · doi:10.1152/physrev.00013.2007 · Cited by 2,842
Self-citationp21 in cancer: Intricate networks and multiple activities
Abbas, T., & Dutta, A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2657 · Cited by 2,712
Stanbrough, M., Bubley, G. J., Ross, K., Golub, T. R., Rubin, M. A., Penning, T. M., Febbo, P. G., & Balk, S. P. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4000 · Cited by 1,082
Mammalian Krüppel-Like Factors in Health and Diseases
McConnell, B. B., & Yang, V. W. (2010) · Physiological Reviews · doi:10.1152/physrev.00058.2009 · Cited by 1,018
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Bracken, A. P., & Helin, K. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2736 · Cited by 523
Metadata
- Authors
- Narla, G., Heath, K. E., Reeves, H. L., Li, D., Giono, L. E., Kimmelman, A. C., Glucksman, M. J., Narla, J., Eng, F. J., Chan, A. M., Ferrari, A. C., Martignetti, J. A., & Friedman, S. L.
- Venue
- Science
- Published
- 2001-12-21
- Volume
- 294
- Issue
- 5551
- Pages
- 2563-2566
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2165983349
- Cited by
- 442
- References
- 0
- FWCI
- 7.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: KLF6 , a Candidate Tumor Suppressor Gene Mutated in Prostate Cancer. https://app.cochat.ai/papers/10.1126/science.1066326
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- Narla, G., Heath, K. E., Reeves, H. L., Li, D., Giono, L. E., Kimmelman, A. C., Glucksman, M. J., Narla, J., Eng, F. J., Chan, A. M., Ferrari, A. C., Martignetti, J. A., & Friedman, S. L. (2001). KLF6 , a Candidate Tumor Suppressor Gene Mutated in Prostate Cancer. Science. https://doi.org/10.1126/science.1066326
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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