The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Bacterial Guanine Nucleotide Exchange Factor Activates ARF on Legionella Phagosomes
Abstract
The intracellular pathogen Legionella pneumophila subverts vesicle traffic in eukaryotic host cells to create a vacuole that supports replication. The dot/icm genes encode a protein secretion apparatus that L. pneumophila require for biogenesis of this vacuole. Here we show that L. pneumophila produce a protein called RalF that functions as an exchange factor for the ADP ribosylation factor (ARF) family of guanosine triphosphatases (GTPases). The RalF protein is required for the localization of ARF on phagosomes containing L. pneumophila . Translocation of RalF protein through the phagosomal membrane is a dot/icm -dependent process. Thus, RalF is a substrate of the Dot/Icm secretion apparatus.
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Cites
The genome sequence of Rickettsia prowazekii and the origin of mitochondria
Andersson, S. G. E., Zomorodipour, A., Andersson, J. O., Sicheritz-Pontén, T., Alsmark, U. C. M., Podowski, R. M., Näslund, A. K., Eriksson, A.-S., Winkler, H. H., & Kurland, C. G. (1998) · Nature · doi:10.1038/24094 · Cited by 1,697
Horwitz, M. A., & Silverstein, S. C. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109874 · Cited by 639
Cited by
Regulation of Small GTPases by GEFs, GAPs, and GDIs
Cherfils, J., & Zeghouf, M. (2013) · Physiological Reviews · doi:10.1152/physrev.00003.2012 · Cited by 1,245
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies
Flannagan, R. S., Cosío, G., & Grinstein, S. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2128 · Cited by 947
Luo, Z.-Q., & Isberg, R. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0304916101 · Cited by 477
The Legionella Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation
Choy, A., Dancourt, J., Mugo, B., O’Connor, T. J., Isberg, R. R., Melia, T. J., & Roy, C. R. (2012) · Science · doi:10.1126/science.1227026 · Cited by 473
Self-citationLegionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites
Kagan, J. C., & Roy, C. R. (2002) · Nature Cell Biology · doi:10.1038/ncb883 · Cited by 444
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Metadata
- Authors
- Nagai, H., Kagan, J. C., Zhu, X., Kahn, R. A., & Roy, C. R.
- Venue
- Science
- Published
- 2002-01-25
- Volume
- 295
- Issue
- 5555
- Pages
- 679-682
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2008034134
- Cited by
- 552
- References
- 2
- FWCI
- 23.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nagai, H., Kagan, J. C., Zhu, X., Kahn, R. A., & Roy, C. R. (2002). A Bacterial Guanine Nucleotide Exchange Factor Activates ARF on Legionella Phagosomes. Science. https://doi.org/10.1126/science.1067025
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