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Adaptive Immune Response of Vγ2Vδ2 + T Cells During Mycobacterial Infections
Open accessAbstract
To examine the role of T cell receptor (TCR) in γδ T cells in adaptive immunity, a macaque model was used to follow Vγ2Vδ2 + T cell responses to mycobacterial infections. These phosphoantigen-specific γδ T cells displayed major expansion during Mycobacterium bovis Bacille Calmette-Guérin (BCG) infection and a clear memory-type response after BCG reinfection. Primary and recall expansions of Vγ2Vδ2 + T cells were also seen during Mycobacterium tuberculosis infection of naı̈ve and BCG-vaccinated macaques, respectively. This capacity to rapidly expand coincided with a clearance of BCG bacteremia and immunity to fatal tuberculosis in BCG-vaccinated macaques. Thus, Vγ2Vδ2 + T cells may contribute to adaptive immunity to mycobacterial infections.
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Cited by
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γδ T cells in tissue physiology and surveillance
Ribot, J. C., Lopes, N., & Silva-Santos, B. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00452-4 · Cited by 532
γδ T cells: origin and fate, subsets, diseases and immunotherapy
Hu, Y., Hu, Q., Li, Y., Lu, L., Xiang, Z., Yin, Z., Kabelitz, D., & Wu, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01653-8 · Cited by 382
Self-citationAnnulling a dangerous liaison: vaccination strategies against AIDS and tuberculosis
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Metadata
- Authors
- Shen, Y., Zhou, D., Qiu, L., Lai, X., Simon, M., Shen, L., Kou, Z., Wang, Q., Jiang, L., Estep, J., Hunt, R., Clagett, M., Sehgal, P. K., Li, Y., Zeng, X., Morita, C. T., Brenner, M. B., Letvin, N. L., & Chen, Z. W.
- Venue
- Science
- Published
- 2002-03-22
- Volume
- 295
- Issue
- 5563
- Pages
- 2255-2258
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1544076059
- Cited by
- 385
- References
- 0
- FWCI
- 14.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Shen, Y., Zhou, D., Qiu, L., Lai, X., Simon, M., Shen, L., Kou, Z., Wang, Q., Jiang, L., Estep, J., Hunt, R., Clagett, M., Sehgal, P. K., Li, Y., Zeng, X., Morita, C. T., Brenner, M. B., Letvin, N. L., & Chen, Z. W. (2002). Adaptive Immune Response of Vγ2Vδ2 + T Cells During Mycobacterial Infections. Science. https://doi.org/10.1126/science.1068819
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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