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A Role for Lipid Shells in Targeting Proteins to Caveolae, Rafts, and Other Lipid Domains
Abstract
The surface membrane of cells is studded with morphologically distinct regions, or domains, like microvilli, cell-cell junctions, and coated pits. Each of these domains is specialized for a particular function, such as nutrient absorption, cell-cell communication, and endocytosis. Lipid domains, which include caveolae and rafts, are one of the least understood membrane domains. These domains are high in cholesterol and sphingolipids, have a light buoyant density, and function in both endocytosis and cell signaling. A major mystery, however, is how resident molecules are targeted to lipid domains. Here, we propose that the molecular address for proteins targeted to lipid domains is a lipid shell.
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Cites
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757
The lipocalin protein family: structural and sequence overview
Flower, D. R., North, A. C. T., & Sansom, C. E. (2000) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(00)00148-5 · Cited by 868
Cited by
Lipid rafts as a membrane-organizing principle
Lingwood, D., & Simons, K. (2010) · Science · doi:10.1126/science.1174621 · Cited by 4,417
Lipid rafts: contentious only from simplistic standpoints
Hancock, J. F. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1925 · Cited by 788
Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model
Norman, A. W., Mizwicki, M. T., & Norman, D. P. G. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1283 · Cited by 569
Lund, E. G., Xie, C., Kotti, T., Turley, S. D., Dietschy, J. M., & Russell, D. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303415200 · Cited by 421
The role of receptor diffusion in the organization of the postsynaptic membrane
Choquet, D., & Triller, A. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1077 · Cited by 414
Metadata
- Authors
- Anderson, R. G. W., & Jacobson, K.
- Venue
- Science
- Published
- 2002-06-07
- Volume
- 296
- Issue
- 5574
- Pages
- 1821-1825
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2025646685
- Cited by
- 1,125
- References
- 2
- FWCI
- 35.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- Anderson, R. G. W., & Jacobson, K. (2002). A Role for Lipid Shells in Targeting Proteins to Caveolae, Rafts, and Other Lipid Domains. Science. https://doi.org/10.1126/science.1068886
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
