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A Thymic Precursor to the NK T Cell Lineage
Abstract
CD1d-restricted autoreactive natural killer (NK1.1 + ) T cells function as regulatory cells in various disease conditions. Using improved tetramer tracking methodology, we identified a NK1.1 – thymic precursor and followed its differentiation and emigration to tissues by direct cell transfer and in situ cell labeling studies. A major lineage expansion occurred within the thymus after positive selection and before NK receptor expression. Surprisingly, cytokine analysis of the developmental intermediates between NK − and NK + stages showed a T helper cell T H 2 to T H 1 conversion, suggesting that the regulatory functions of NK T cells may be developmentally controlled. These findings characterize novel thymic and postthymic developmental pathways that expand autoreactive cells and differentiate them into regulatory cells.
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Cited by
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Starr, T. K., Jameson, S. C., & Hogquist, K. A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141107 · Cited by 1,601
Kubes, P., & Jenne, C. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052415 · Cited by 923
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Vivier, E., Ugolini, S., Blaise, D., Chabannon, C., & Brossay, L. (2012) · Nature Reviews Immunology · doi:10.1038/nri3174 · Cited by 850
Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions
Brennan, P. J., Brigl, M., & Brenner, M. B. (2013) · Nature Reviews Immunology · doi:10.1038/nri3369 · Cited by 835
T-bet Regulates the Terminal Maturation and Homeostasis of NK and Vα14i NKT Cells
Townsend, M. J., Weinmann, A. S., Matsuda, J. L., Salomon, R., Farnham, P. J., Biron, C. A., Gapin, L., & Glimcher, L. H. (2004) · Immunity · doi:10.1016/s1074-7613(04)00076-7 · Cited by 722
Metadata
- Authors
- Benlagha, K., Kyin, T., Beavis, A., Teyton, L., & Bendelac, A.
- Venue
- Science
- Published
- 2002-04-19
- Volume
- 296
- Issue
- 5567
- Pages
- 553-555
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1984510622
- Cited by
- 519
- References
- 0
- FWCI
- 11.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Benlagha, K., Kyin, T., Beavis, A., Teyton, L., & Bendelac, A. (2002). A Thymic Precursor to the NK T Cell Lineage. Science. https://doi.org/10.1126/science.1069017
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