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A Thymic Precursor to the NK T Cell Lineage
Abstract
CD1d-restricted autoreactive natural killer (NK1.1 + ) T cells function as regulatory cells in various disease conditions. Using improved tetramer tracking methodology, we identified a NK1.1 – thymic precursor and followed its differentiation and emigration to tissues by direct cell transfer and in situ cell labeling studies. A major lineage expansion occurred within the thymus after positive selection and before NK receptor expression. Surprisingly, cytokine analysis of the developmental intermediates between NK − and NK + stages showed a T helper cell T H 2 to T H 1 conversion, suggesting that the regulatory functions of NK T cells may be developmentally controlled. These findings characterize novel thymic and postthymic developmental pathways that expand autoreactive cells and differentiate them into regulatory cells.
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Metadata
- Authors
- Benlagha, K., Kyin, T., Beavis, A., Teyton, L., & Bendelac, A.
- Venue
- Science
- Published
- 2002-04-19
- Volume
- 296
- Issue
- 5567
- Pages
- 553-555
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1984510622
- Cited by
- 519
- References
- 0
- FWCI
- 11.79
- Type
- journal article
- Language
- en
- Open access
- closed
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