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Induction and Suppression of RNA Silencing by an Animal Virus
Abstract
RNA silencing is a sequence-specific RNA degradation mechanism that is operational in plants and animals. Here, we show that flock house virus (FHV) is both an initiator and a target of RNA silencing in Drosophila host cells and that FHV infection requires suppression of RNA silencing by an FHV-encoded protein, B2. These findings establish RNA silencing as an adaptive antiviral defense in animal cells. B2 also inhibits RNA silencing in transgenic plants, providing evidence for a conserved RNA silencing pathway in the plant and animal kingdoms.
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Cited by
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
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Meister, G., Landthaler, M., Patkaniowska, A., Dorsett, Y., Teng, G., & Tuschl, T. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.07.007 · Cited by 2,052
The Small RNA Profile during Drosophila melanogaster Development
Aravin, A. A., Lagos-Quintana, M., Yalcin, A., Zavolan, M., Marks, D., Snyder, B., Gaasterland, T., Meyer, J., & Tuschl, T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00228-4 · Cited by 802
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PILLAI, R. S. (2005) · RNA · doi:10.1261/rna.2248605 · Cited by 681
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Metadata
- Authors
- Li, H., Li, W. X., & Ding, S. W.
- Venue
- Science
- Published
- 2002-05-17
- Volume
- 296
- Issue
- 5571
- Pages
- 1319-1321
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2166293484
- Cited by
- 868
- References
- 0
- FWCI
- 87.91
- Type
- journal article
- Language
- en
- Open access
- closed
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