Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Among the four members of the AGO family in human and mouse, only AGO2 exhibits endonuclease activity.
“Among the four members in the AGO family in human and mouse, only AGO2 exhibits endoneuclase activity (Meister et al., 2004, Ikeda et al., 2006) and is indispensible for Dicer-independent miRNA biogenesis (Cheloufi et al., 2010).”
From Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain (2012) · cites this paper as Meister et al., 2004
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Sarot, E., Payen-Groschêne, G., Bucheton, A., & Pélisson, A. (2004) · Genetics · doi:10.1534/genetics.166.3.1313 · Cited by 251 · see citing works
Flagged first, then by citations
Research works printed but not linked: 39
- [1]1. Aravin, A.A ∙ Lagos-Quintana, M ∙ Yalcin, A ... The small RNA profile during Drosophila melanogaster development Dev. Cell. 2003; 5:337-350 Full Text Full Text (PDF) Scopus (503) PubMed Google Scholar
- [2]2. Aravin, A.A ∙ Naumova, N.M ∙ Tulin, A.V ... Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline Curr. Biol. 2001; 11:1017-1027 Full Text Full Text (PDF) Scopus (363) PubMed Google Scholar
- [3]3. Aukerman, M.J ∙ Sakai, H Regulation of flowering time and floral organ identity by a microRNA and its APETALA2-like target genes Plant Cell. 2003; 15:2730-2741 Crossref Scopus (685) PubMed Google Scholar
- [4]4. Bartel, D.P MicroRNAsgenomics, biogenesis, mechanism, and function Cell. 2004; 116:281-297 Full Text Full Text (PDF) Scopus (9232) PubMed Google Scholar
- [5]5. Béclin, C ∙ Boutet, S ∙ Waterhouse, P ... A branched pathway for transgene-induced RNA silencing in plants Curr. Biol. 2002; 12:684-688 Full Text Full Text (PDF) Scopus (141) PubMed Google Scholar
- [6]6. Bernstein, E ∙ Caudy, A.A ∙ Hammond, S.M ... Role for a bidentate ribonuclease in the initiation step of RNA interference Nature. 2001; 409:363-366 Crossref Scopus (2420) PubMed Google Scholar
- [7]7. Bernstein, E ∙ Kim, S.Y ∙ Carmell, M.A ... Dicer is essential for mouse development Nat. Genet. 2003; 35:215-217 Crossref Scopus (893) PubMed Google Scholar
- [8]8. Billy, E ∙ Brondani, V ∙ Zhang, H ... Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines Proc. Natl. Acad. Sci. USA. 2001; 98:14428-14433 Crossref Scopus (275) PubMed Google Scholar
- [9]9. Bohmert, K ∙ Camus, I ∙ Bellini, C ... AGO1 defines a novel locus of Arabidopsis controlling leaf development EMBO J. 1998; 17:170-180 Crossref Scopus (300) PubMed Google Scholar
- [10]10. Bosher, J.M ∙ Dufourcq, P ∙ Sookhareea, S ... RNA interference can target pre-mRNAconsequences for gene expression in a Caenorhabditis elegans operon Genetics. 1999; 153:1245-1256 Crossref PubMed Google Scholar
- [11]11. Carmell, M.A ∙ Hannon, G.J RNase III enzymes and the initiation of gene silencing Nat. Struct. Mol. Biol. 2004; 11:214-218 Crossref Scopus (221) PubMed Google Scholar
- [12]12. Carmell, M.A ∙ Xuan, Z ∙ Zhang, M.Q ... The Argonaute familytentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis Genes Dev. 2002; 16:2733-2742 Crossref Scopus (481) PubMed Google Scholar
- [13]13. Carrington, J.C ∙ Ambros, V Role of microRNAs in plant and animal development Science. 2003; 301:336-338 Crossref Scopus (758) PubMed Google Scholar
- [14]14. Catalanotto, C ∙ Pallotta, M ∙ ReFalo, P ... Redundancy of the two dicer genes in transgene-induced posttranscriptional gene silencing in Neurospora crassa Mol. Cell. Biol. 2004; 24:2536-2545 Crossref Scopus (86) PubMed Google Scholar
- [15]15. Caudy, A.A ∙ Myers, M ∙ Hannon, G.J ... Fragile X-related protein and VIG associate with the RNA interference machinery Genes Dev. 2002; 16:2491-2496 Crossref Scopus (413) PubMed Google Scholar
- [16]16. Cerutti, L ∙ Mian, N ∙ Bateman, A Domains in gene silencing and cell differentiation proteinsthe novel PAZ domain and redefinition of the piwi domain Trends Biochem. Sci. 2000; 25:481-482 Full Text Full Text (PDF) Scopus (245) PubMed Google Scholar
- [17]17. Chan, S.W ∙ Zilberman, D ∙ Xie, Z ... RNA silencing genes control de novo DNA methylation Science. 2004; 303:1336 Crossref Scopus (298) PubMed Google Scholar
- [18]18. Dalmay, T ∙ Hamilton, A ∙ Rudd, S ... An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus Cell. 2000; 101:543-553 Full Text Full Text (PDF) PubMed Google Scholar
- [19]19. Deng, W ∙ Lin, H miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis Dev. Cell. 2002; 2:819-830 Full Text Full Text (PDF) Scopus (315) PubMed Google Scholar
- [20]20. Denli, A.M ∙ Hannon, G.J Rnaian ever-growing puzzle Trends Biochem. Sci. 2003; 28:196-201 Full Text Full Text (PDF) Scopus (194) PubMed Google Scholar
- [21]21. Dignam, J.D ∙ Lebovitz, R.M ∙ Roeder, R.G Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei Nucleic Acids Res. 1983; 11:1475-1489 Crossref Scopus (6372) PubMed Google Scholar
- [22]22. Doi, N ∙ Zenno, S ∙ Ueda, R ... Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors Curr. Biol. 2003; 13:41-46 Full Text Full Text (PDF) Scopus (144) PubMed Google Scholar
- [23]23. Dorsett, Y ∙ Tuschl, T siRNAsapplications in functional genomics and potential as therapeutics Nat. Rev. Drug Discov. 2004; 3:318-329 Crossref PubMed Google Scholar
- [24]24. Dostie, J ∙ Mourelatos, Z ∙ Yang, M ... Numerous microRNPs in neuronal cells containing novel microRNAs RNA. 2003; 9:180-186 Crossref Scopus (188) PubMed Google Scholar
- [25]25. Dykxhoorn, D.M ∙ Novina, C.D ∙ Sharp, P.A Killing the messengershort RNAs that silence gene expression Nat. Rev. Mol. Cell Biol. 2003; 4:457-467 Crossref Scopus (794) PubMed Google Scholar
- [26]26. Elbashir, S.M ∙ Lendeckel, W ∙ Tuschl, T RNA interference is mediated by 21 and 22 nt RNAs Genes Dev. 2001; 15:188-200 Crossref Scopus (2055) PubMed Google Scholar
- [27]27. Elbashir, S.M ∙ Martinez, J ∙ Patkaniowska, A ... Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate EMBO J. 2001; 20:6877-6888 Crossref Scopus (926) PubMed Google Scholar
- [28]28. Fagard, M ∙ Boutet, S ∙ Morel, J.B ... AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals Proc. Natl. Acad. Sci. USA. 2000; 97:11650-11654 Crossref PubMed Google Scholar
- [29]29. Finnegan, E.J ∙ Matzke, M.A The small RNA world J. Cell Sci. 2003; 116:4689-4693 Crossref Scopus (81) PubMed Google Scholar
- [30]30. Fire, A ∙ Xu, S ∙ Montgomery, M.K ... Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature. 1998; 391:806-811 Crossref Scopus (6975) PubMed Google Scholar
- [31]31. Grewal, S.I ∙ Moazed, D Heterochromatin and epigenetic control of gene expression Science. 2003; 301:798-802 Crossref Scopus (540) PubMed Google Scholar
- [32]32. Grishok, A ∙ Pasquinelli, A.E ∙ Conte, D ... Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing Cell. 2001; 106:23-34 Full Text Full Text (PDF) Scopus (987) PubMed Google Scholar
- [33]33. Haley, B ∙ Zamore, P.D Kinetic analysis of the RNAi enzyme complex Nat. Struct. Mol. Biol. 2004; 11:599-606 Crossref Scopus (290) PubMed Google Scholar
- [34]34. Hamilton, A ∙ Voinnet, O ∙ Chappell, L ... Two classes of short interfering RNA in RNA silencing EMBO J. 2002; 21:4671-4679 Crossref Scopus (580) PubMed Google Scholar
- [35]35. Hammond, S.M ∙ Bernstein, E ∙ Beach, D ... An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells Nature. 2000; 404:293-296 Crossref Scopus (1729) PubMed Google Scholar
- [36]36. Hammond, S.M ∙ Boettcher, S ∙ Caudy, A.A ... Argonaute2, a link between genetic and biochemical analyses of RNAi Science. 2001; 293:1146-1150 Crossref Scopus (806) PubMed Google Scholar
- [37]37. Hannon, G.J RNA interference Nature. 2002; 418:244-251 Crossref Scopus (2469) PubMed Google Scholar
- [38]38. Hirotsune, S ∙ Yoshida, N ∙ Chen, A ... An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene Nature. 2003; 423:91-96 Crossref Scopus (263) PubMed Google Scholar
- [39]39. Ho, C.K ∙ Wang, L.K ∙ Lima, C.D ... Structure and mechanism of RNA ligase Structure (Camb). 2004; 12:327-339
Cited by
Sorted by citations
Regulation of microRNA biogenesis
Ha, M., & Kim, V. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3838 · Cited by 5,462 · see citing works
The widespread regulation of microRNA biogenesis, function and decay
Krol, J., Loedige, I., & Filipowicz, W. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2843 · Cited by 4,672 · see citing works
Circular RNAs are abundant, conserved, and associated with ALU repeats
Jeck, W. R., Sorrentino, J. A., Wang, K., Slevin, M. K., Burd, C. E., Liu, J., Marzluff, W. F., & Sharpless, N. E. (2013) · RNA · doi:10.1261/rna.035667.112 · Cited by 4,388 · see citing works
Arroyo, J. D., Chevillet, J. R., Kroh, E. M., Ruf, I. K., Pritchard, C. C., Gibson, D. F., Mitchell, P. S., Bennett, C. F., Pogosova-Agadjanyan, E. L., Stirewalt, D. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019055108 · Cited by 3,294 · see citing works
The evolution of gene regulation by transcription factors and microRNAs
Chen, K., & Rajewsky, N. (2007) · Nature Reviews Genetics · doi:10.1038/nrg1990 · Cited by 1,547 · see citing works
Crooke, S. T., Witztum, J. L., Bennett, C. F., & Baker, B. F. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.004 · Cited by 841 · see citing works
Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132
Edbauer, D., Neilson, J. R., Foster, K. A., Wang, C.-F., Seeburg, D. P., Batterton, M. N., Tada, T., Dolan, B. M., Sharp, P. A., & Sheng, M. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.005 · Cited by 735 · see citing works
AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2
Vasudevan, S., & Steitz, J. A. (2007) · Cell · doi:10.1016/j.cell.2007.01.038 · Cited by 656 · see citing works
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration
Kaneko, H., Dridi, S., Tarallo, V., Gelfand, B. D., Fowler, B. J., Cho, W. G., Kleinman, M. E., Ponicsan, S. L., Hauswirth, W. W., Chiodo, V. A., et al. (2011) · Nature · doi:10.1038/nature09830 · Cited by 601 · see citing works
Pu, M., Chen, J., Tao, Z., Miao, L., Qi, X., Wang, Y., & Ren, J. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2940-7 · Cited by 500 · see citing works
Kawamata, T., & Tomari, Y. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.03.009 · Cited by 481 · see citing works
Life of RISC: Formation, action, and degradation of RNA-induced silencing complex
Iwakawa, H.-O., & Tomari, Y. (2022) · Molecular Cell · doi:10.1016/j.molcel.2021.11.026 · Cited by 488 · see citing works
ATP-dependent human RISC assembly pathways
Yoda, M., Kawamata, T., Paroo, Z., Ye, X., Iwasaki, S., Liu, Q., & Tomari, Y. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1733 · Cited by 380 · see citing works
Control of alternative splicing through siRNA-mediated transcriptional gene silencing
Alló, M., Buggiano, V., Fededa, J. P., Petrillo, E., Schor, I., de la Mata, M., Agirre, E., Plass, M., Eyras, E., Elela, S. A., et al. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1620 · Cited by 340 · see citing works
Hartmann, G. (2017) · Advances in Immunology · doi:10.1016/bs.ai.2016.11.001 · Cited by 285 · see citing works
From guide to target: molecular insights into eukaryotic RNA-interference machinery
Ipsaro, J. J., & Joshua-Tor, L. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2931 · Cited by 281 · see citing works
Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain
He, M., Liu, Y., Wang, X., Zhang, M. Q., Hannon, G. J., & Huang, Z. J. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.010 · Cited by 277 · see citing works
The regulation of mRNA stability in mammalian cells: 2.0
Wu, X., & Brewer, G. (2012) · Gene · doi:10.1016/j.gene.2012.03.021 · Cited by 239 · see citing works
Human Argonaute 2 Has diverse reaction pathways on Target RNAs
Jo, M. H., Shin, S., Jung, S.-R., Kim, E., Song, J.-J., & Hohng, S. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.04.027 · Cited by 207 · see citing works
General Principals of miRNA Biogenesis and Regulation in the Brain
O'Carroll, D., & Schaefer, A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.87 · Cited by 205 · see citing works
Reexamining assumptions about miRNA-guided gene silencing
Kilikevicius, A., Meister, G., & Corey, D. R. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkab1256 · Cited by 194 · see citing works
Self-citationHuman TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus
Nishi, K., Nishi, A., Nagasawa, T., & Ui-Tei, K. (2013) · RNA · doi:10.1261/rna.034769.112 · Cited by 188 · see citing works
Kundu, P., Fabian, M. R., Sonenberg, N., Bhattacharyya, S. N., & Filipowicz, W. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks148 · Cited by 180 · see citing works
Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development
Nowakowski, T. J., Rani, N., Golkaram, M., Zhou, H. R., Alvarado, B., Huch, K., West, J. A., Leyrat, A., Pollen, A. A., Kriegstein, A. R., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0265-3 · Cited by 166 · see citing works
Bridge RNAs direct programmable recombination of target and donor DNA
Durrant, M. G., Perry, N. T., Pai, J. J., Jangid, A. R., Athukoralage, J. S., Hiraizumi, M., McSpedon, J. P., Pawluk, A., Nishimasu, H., Konermann, S., et al. (2024) · Nature · doi:10.1038/s41586-024-07552-4 · Cited by 163 · see citing works
Development of Therapeutic-Grade Small Interfering RNAs by Chemical Engineering
Bramsen, J. B., & Kjems, J. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00154 · Cited by 92 · see citing works
Detzer, A., Engel, C., Wünsche, W., & Sczakiel, G. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1216 · Cited by 74 · see citing works
Xu, J., Chen, Q., Zen, K., Zhang, C., & Zhang, Q. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12057 · Cited by 61 · see citing works
Control of the localization and function of a miRNA silencing component TNRC6A by Argonaute protein
Nishi, K., Takahashi, T., Suzawa, M., Miyakawa, T., Nagasawa, T., Ming, Y., Tanokura, M., & Ui-Tei, K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1026 · Cited by 43 · see citing works
Early onset senescence and cognitive impairment in a murine model of repeated mTBI
Schwab, N., Ju, Y., & Hazrati, L.-N. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01190-x · Cited by 39 · see citing works
RNA-based therapeutics to treat human fungal infections
Bruch, A., Kelani, A. A., & Blango, M. G. (2022) · Trends in Microbiology · doi:10.1016/j.tim.2021.09.007 · Cited by 39 · see citing works
Naik, S., Shreya, A. B., Raychaudhuri, R., Pandey, A., Lewis, S. A., Hazarika, M., Bhandary, S. V., Rao, B. S. S., & Mutalik, S. (2021) · Life Sciences · doi:10.1016/j.lfs.2020.118712 · Cited by 33 · see citing works
de Bartolomeis, A., Iasevoli, F., Tomasetti, C., & Buonaguro, E. F. (2015) · Molecular Neurobiology · doi:10.1007/s12035-014-8962-8 · Cited by 21 · see citing works
- Authors
- Meister, G., Landthaler, M., Patkaniowska, A., Dorsett, Y., Teng, G., & Tuschl, T.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2004-07
- Volume
- 15
- Issue
- 2
- Pages
- 185-197
- ISSN
- 1097-2765
- Cited by
- 1,718
- References
- 1
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
