The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Direct Patterning of Modified Oligonucleotides on Metals and Insulators by Dip-Pen Nanolithography
Abstract
The use of direct-write dip-pen nanolithography (DPN) to generate covalently anchored, nanoscale patterns of oligonucleotides on both metallic and insulating substrates is described. Modification of DNA with hexanethiol groups allowed patterning on gold, and oligonucleotides bearing 5′-terminal acrylamide groups could be patterned on derivatized silica. Feature sizes ranging from many micrometers to less than 100 nanometers were achieved, and the resulting patterns exhibited the sequence-specific binding properties of the DNA from which they were composed. The patterns can be used to direct the assembly of individual oligonucleotide-modified particles on a surface, and the deposition of multiple DNA sequences in a single array is demonstrated.
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Self-citationNanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials Science
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Protein Nanoarrays Generated By Dip-Pen Nanolithography
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Metadata
- Authors
- Demers, L. M., Ginger, D. S., Park, S.-J., Li, Z., Chung, S.-W., & Mirkin, C. A.
- Venue
- Science
- Published
- 2002-06-07
- Volume
- 296
- Issue
- 5574
- Pages
- 1836-1838
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1986501756
- Cited by
- 721
- References
- 16
- FWCI
- 48.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- Demers, L. M., Ginger, D. S., Park, S.-J., Li, Z., Chung, S.-W., & Mirkin, C. A. (2002). Direct Patterning of Modified Oligonucleotides on Metals and Insulators by Dip-Pen Nanolithography. Science. https://doi.org/10.1126/science.1071480
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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