The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway
Abstract
The coagulant and inflammatory exacerbation in sepsis is counterbalanced by the protective protein C (PC) pathway. Activated PC (APC) was shown to use the endothelial cell PC receptor (EPCR) as a coreceptor for cleavage of protease activated receptor 1 (PAR1) on endothelial cells. Gene profiling demonstrated that PAR1 signaling could account for all APC-induced protective genes, including the immunomodulatory monocyte chemoattractant protein-1 (MCP-1), which was selectively induced by activation of PAR1, but not PAR2. Thus, the prototypical thrombin receptor is the target for EPCR-dependent APC signaling, suggesting a role for this receptor cascade in protection from sepsis.
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Cites
Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice
Lee, E. G., Boone, D. L., Chai, S., Libby, S. L., Chien, M., Lodolce, J. P., & Ma, A. (2000) · Science · doi:10.1126/science.289.5488.2350 · Cited by 1,409
Cited by
The immunopathogenesis of sepsis
Cohen, J. (2002) · Nature · doi:10.1038/nature01326 · Cited by 2,742
Points of control in inflammation
Nathan, C. (2002) · Nature · doi:10.1038/nature01320 · Cited by 2,738
Extracellular histones are major mediators of death in sepsis
Xu, J., Zhang, X., Pelayo, R., Monestier, M., Ammollo, C. T., Semeraro, F., Taylor, F. B., Esmon, N. L., Lupu, F., & Esmon, C. T. (2009) · Nature Medicine · doi:10.1038/nm.2053 · Cited by 1,539
Novel strategies for the treatment of sepsis
Riedemann, N. C., Guo, R.-F., & Ward, P. A. (2003) · Nature Medicine · doi:10.1038/nm0503-517 · Cited by 773
Esmon, C. T. (2003) · Chest · doi:10.1378/chest.124.3_suppl.26s · Cited by 719
Metadata
- Authors
- Riewald, M., Petrovan, R. J., Donner, A., Mueller, B. M., & Ruf, W.
- Venue
- Science
- Published
- 2002-06-07
- Volume
- 296
- Issue
- 5574
- Pages
- 1880-1882
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2000985786
- Cited by
- 831
- References
- 1
- FWCI
- 24.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Riewald, M., Petrovan, R. J., Donner, A., Mueller, B. M., & Ruf, W. (2002). Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway. Science. https://doi.org/10.1126/science.1071699
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
