The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Regulation of Hypoxic Death in C. elegans by the Insulin/IGF Receptor Homolog DAF-2
Abstract
To identify genetic determinants of hypoxic cell death, we screened for hypoxia-resistant (Hyp) mutants in Caenorhabditis elegans and found that specific reduction-of-function (rf) mutants of daf-2 , an insulin/insulinlike growth factor (IGF) receptor (INR) homolog gene, were profoundly Hyp. The hypoxia resistance was acutely inducible just before hypoxic exposure and was mediated through an AKT-1/PDK-1/forkhead transcription factor pathway overlapping with but distinct from signaling pathways regulating life-span and stress resistance. Selective neuronal and muscle expression of daf-2 (+) restored hypoxic death, and daf-2 (rf) prevented hypoxia-induced muscle and neuronal cell death, which demonstrates a potential for INR modulation in prophylaxis against hypoxic injury of neurons and myocytes.
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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Wingrove, J. A., & O'Farrell, P. H. (1999) · Cell · doi:10.1016/s0092-8674(00)80610-8 · Cited by 249
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Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053
Simonsen, A., Cumming, R. C., Brech, A., Isakson, P., Schubert, D. R., & Finley, K. D. (2008) · Autophagy · doi:10.4161/auto.5269 · Cited by 716
Insulin/insulin-like growth factor signaling in C. elegans
Murphy, C. T. (2013) · WormBook · doi:10.1895/wormbook.1.164.1 · Cited by 532
Reiling, J. H., & Sabatini, D. M. (2006) · Oncogene · doi:10.1038/sj.onc.1209889 · Cited by 311
The Sodium-Activated Potassium Channel Is Encoded by a Member of the Slo Gene Family
Yuan, A., Santi, C. M., Wei, A., Wang, Z.-W., Pollak, K., Nonet, M., Kaczmarek, L., Crowder, C. M., & Salkoff, L. (2003) · Neuron · doi:10.1016/s0896-6273(03)00096-5 · Cited by 288
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Metadata
- Authors
- Scott, B. A., Avidan, M. S., & Crowder, C. M.
- Venue
- Science
- Published
- 2002-06-28
- Volume
- 296
- Issue
- 5577
- Pages
- 2388-2391
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2011912518
- Cited by
- 245
- References
- 2
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Scott, B. A., Avidan, M. S., & Crowder, C. M. (2002). Regulation of Hypoxic Death in C. elegans by the Insulin/IGF Receptor Homolog DAF-2. Science. https://doi.org/10.1126/science.1072302
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