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A Heat-Sensitive TRP Channel Expressed in Keratinocytes
Open accessAbstract
Mechanical and thermal cues stimulate a specialized group of sensory neurons that terminate in the skin. Three members of the transient receptor potential (TRP) family of channels are expressed in subsets of these neurons and are activated at distinct physiological temperatures. Here, we describe the cloning and characterization of a novel thermosensitive TRP channel. TRPV3 has a unique threshold: It is activated at innocuous (warm) temperatures and shows an increased response at noxious temperatures. TRPV3 is specifically expressed in keratinocytes; hence, skin cells are capable of detecting heat via molecules similar to those in heat-sensing neurons.
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Citations
Cited by
Cellular and Molecular Mechanisms of Pain
Basbaum, A. I., Bautista, D. M., Scherrer, G., & Julius, D. (2009) · Cell · doi:10.1016/j.cell.2009.09.028 · Cited by 4,344
TRP channels as cellular sensors
Clapham, D. E. (2003) · Nature · doi:10.1038/nature02196 · Cited by 2,779
Skin blood flow in adult human thermoregulation: How it works, when it does not, and why
Charkoudian, N. (2003) · Mayo Clinic Proceedings · doi:10.4065/78.5.603 · Cited by 1,041
Membrane fluidity and its roles in the perception of environmental signals
Los, D. A., & Murata, N. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2004.08.002 · Cited by 1,020
ThermoTRP channels and beyond: mechanisms of temperature sensation
Patapoutian, A., Peier, A. M., Story, G. M., & Viswanath, V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1141 · Cited by 873
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Metadata
- Authors
- Peier, A. M., Reeve, A. J., Andersson, D. A., Moqrich, A., Earley, T. J., Hergarden, A. C., Story, G. M., Colley, S., Hogenesch, J. B., McIntyre, P., Bevan, S., & Patapoutian, A.
- Venue
- Science
- Published
- 2002-06-14
- Volume
- 296
- Issue
- 5575
- Pages
- 2046-2049
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2100241249
- Cited by
- 970
- References
- 0
- FWCI
- 16.37
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A Heat-Sensitive TRP Channel Expressed in Keratinocytes. https://app.cochat.ai/papers/10.1126/science.1073140
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- Peier, A. M., Reeve, A. J., Andersson, D. A., Moqrich, A., Earley, T. J., Hergarden, A. C., Story, G. M., Colley, S., Hogenesch, J. B., McIntyre, P., Bevan, S., & Patapoutian, A. (2002). A Heat-Sensitive TRP Channel Expressed in Keratinocytes. Science. https://doi.org/10.1126/science.1073140
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