The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Inhibition of Retroviral RNA Production by ZAP, a CCCH-Type Zinc Finger Protein
Abstract
Cells have evolved multiple mechanisms to inhibit viral replication. To identify previously unknown antiviral activities, we screened mammalian complementary DNA (cDNA) libraries for genes that prevent infection by a genetically marked retrovirus. Virus-resistant cells were selected from pools of transduced clones, and an active antiviral cDNA was recovered. The gene encodes a CCCH-type zinc finger protein designated ZAP. Expression of the gene caused a profound and specific loss of viral messenger RNAs (mRNAs) from the cytoplasm without affecting the levels of nuclear mRNAs. The finding suggests the existence of a previously unknown machinery for the inhibition of virus replication, targeting a step in viral gene expression.
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Cites
AU Binding Proteins Recruit the Exosome to Degrade ARE-Containing mRNAs
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Interactions of CCCH Zinc Finger Proteins with mRNA
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Poly(ADP-ribose): novel functions for an old molecule
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TRIM family proteins: retroviral restriction and antiviral defence
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PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes
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“Examples where the sites of ADP-ribosylation on target proteins have been mapped are NFAT (ADP-ribosylation increases DNA binding) (Olabisi et al. 2008), p53 (ADPribosylation inhibits nuclear export) (Kanai et al. 2007), CTFC (ADP-ribosylation is required for optimal function in transcriptional activation and insulato…”
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Metadata
- Authors
- Gao, G., Guo, X., & Goff, S. P.
- Venue
- Science
- Published
- 2002-09-06
- Volume
- 297
- Issue
- 5587
- Pages
- 1703-1706
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1503306485
- Cited by
- 469
- References
- 17
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gao, G., Guo, X., & Goff, S. P. (2002). Inhibition of Retroviral RNA Production by ZAP, a CCCH-Type Zinc Finger Protein. Science. https://doi.org/10.1126/science.1074276
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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